Tumor-Suppressive Functions of the Aryl Hydrocarbon Receptor (AhR) and AhR as a Therapeutic Target in Cancer [PDF]
Biology, 2023 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in regulating a wide range of biological responses. A diverse array of xenobiotics and endogenous small molecules bind to the receptor and drive unique phenotypic ...
Daniel J. Elson, Siva K. Kolluri
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The Role of Aryl-Hydrocarbon Receptor (AhR) in Osteoclast Differentiation and Function [PDF]
Cells, 2020 Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays a crucial role in bone remodeling through altering the interplay between bone-forming osteoblasts and bone-resorbing osteoclasts.
Robin Park +2 more
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Functions of the Aryl Hydrocarbon Receptor (AHR) Beyond the Canonical AHR/ARNT Signaling Pathway [PDF]
Biochemical Pharmacology, 2023 Thomas Haarmann-Stemmann +2 more
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Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)? [PDF]
International Journal of Molecular Sciences, 2021 Carolina Tafalla +2 more
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The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors [PDF]
International Journal of Molecular Sciences, 2020 Maria Perepechaeva +1 more
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Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor
Nature Communications, 2022 The aryl hydrocarbon receptor (AHR) plays important roles in regulating xenobiotic metabolism, cellular differentiation, and immunity. Here, the authors present multiple crystal structures of the Drosophila AHR PAS-B domain, providing insights into the ...
Shuyan Dai +8 more
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Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs. [PDF]
PLoS ONE, 2013 The aryl hydrocarbon receptor (AHR) mediates biological responses to toxic chemicals. An unexpected role for AHR in vascularization was suggested when mice lacking AHR displayed impaired closure of the ductus venosus after birth, as did knockout mice for
Frank G van Steenbeek +10 more
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Aryl Hydrocarbon Receptor Mechanisms Affecting Chronic Kidney Disease
Frontiers in Pharmacology, 2022 The aryl hydrocarbon receptor (AHR) is a basic helix-loop-helix transcription factor that binds diverse endogenous and xenobiotic ligands, which regulate AHR stability, transcriptional activity, and cell signaling.
Colleen S. Curran, Jeffrey B. Kopp
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Frontiers in Immunology, 2022 The aryl hydrocarbon receptor was previously known as an environmental receptor that modulates the cellular response to external environmental changes. In essence, the aryl hydrocarbon receptor is a cytoplasmic receptor and transcription factor that is ...
Jingwen Wu +4 more
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Microbiology Spectrum, 2021 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcript factor that plays an important role in regulating immunity and cell differentiation. However, its role in cell-autonomous antiviral resistance has not been fully elucidated.
Jincheng Chen +11 more
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