Results 11 to 20 of about 11,887 (214)

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor AResearch in context [PDF]

EBioMedicine, 2019
Background: The identification of new biomarkers and the development of novel, targetable contexts of vulnerability are of urgent clinical need in drug-resistant metastatic colorectal cancer (mCRC).
Elke Burgermeister, Francesca Battaglin, Fagr Eladly, Wen Wu, Frank Herweck, Nadine Schulte, Johannes Betge, Nicolai Härtel, Jakob N. Kather, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Christel Weiss, Ralf Hofheinz, Ian S. Miller, Fotios Loupakis, Heinz-Josef Lenz, Annette T. Byrne, Matthias P. Ebert   +18 more
doaj   +2 more sources

Research Progress of BMAL1 in Heart Failure [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Heart failure represents the terminal stage of cardiovascular disease, with cardiac remodeling as a key pathological feature. As a core circadian clock gene, brain and muscle aryl hydrocarbon receptor nuclear translocator‐like 1 (BMAL1) not only ...
Fengling Chen, Haibing Yang, Xiaolei Fu, Zhi Liu, Yajie Chen, Ting Xu, Zhu Chen, Xin Luo, Chengming Wang, Yuan Guo   +9 more
doaj   +2 more sources

Deletion of ARNT (Aryl hydrocarbon receptor nuclear translocator) in β-cells causes islet transplant failure with impaired β-cell function. [PDF]

PLoS ONE, 2014
BackgroundReplacing β-cells by islet-transplantation can cure type 1 diabetes, but up to 70% of β-cells die within 10 days of transplantation. ARNT (Aryl hydrocarbon Receptor Nuclear Translocator) regulates β-cell function, and potentially survival. Lack
Amit Lalwani, Rebecca A Stokes, Sue Mei Lau, Jenny E Gunton   +3 more
doaj   +2 more sources

Differential suppression of the aryl hydrocarbon receptor nuclear translocator-dependent function by an aryl hydrocarbon receptor PAS-A-derived inhibitory molecule [PDF]

Biochemical Pharmacology, 2014
The aryl hydrocarbon receptor (AhR) heterodimerizes with the aryl hydrocarbon receptor nuclear translocator (Arnt) for transcriptional regulation. We generated three N-terminal deletion constructs of the human AhR of 12-24 kDa in size--namely D1, D2, and D3--to suppress the Arnt function.
Jinghang, Xie, Xin, Huang, Miki S, Park, Hang M, Pham, William K, Chan   +4 more
openaire   +3 more sources

ARNT (aryl hydrocarbon receptor nuclear translocator) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ARNT (aryl hydrocarbon receptor nuclear translocator), with data on DNA, on the protein encoded, and where the gene is implicated.
  +4 more sources

MIR-320a/b inhibits cell viability and cell cycle progression by targeting aryl hydrocarbon receptor nuclear translocator-like in acute promyelocyte leukaemia

Polish Journal of Pathology, 2022
Acute promyelocyte leukaemia (APL) is a subgroup of acute myeloid leukaemia. Dysregulation of clock genes has been revealed to be involved in APL progression. Herein, the mechanism of clock gene aryl hydrocarbon receptor nuclear translocator- like (ARNTL)
Dan Hu, Zhenji Shen, Lin Yuan
doaj   +1 more source

Integration of circadian and hypoxia signaling via non-canonical heterodimerization. [PDF]

FEBS Lett
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Wang S, Lamia KA.
europepmc   +2 more sources

Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs. [PDF]

PLoS ONE, 2013
The aryl hydrocarbon receptor (AHR) mediates biological responses to toxic chemicals. An unexpected role for AHR in vascularization was suggested when mice lacking AHR displayed impaired closure of the ductus venosus after birth, as did knockout mice for
Frank G van Steenbeek, Bart Spee, Louis C Penning, Anne Kummeling, Ingrid H M van Gils, Guy C M Grinwis, Dik Van Leenen, Frank C P Holstege, Manon Vos-Loohuis, Jan Rothuizen, Peter A J Leegwater   +10 more
doaj   +1 more source

Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β

BMC Pharmacology and Toxicology, 2022
Background The main causes of lung cancer are smoking, environmental pollution and genetic susceptibility. It is an indisputable fact that PAHs are related to lung cancer, and benzo(a) pyrene is a representative of PAHs.
Mengdi Zhang, Yuxia Hu, Fan Yang, Jingwen Zhang, Jianxin Zhang, Wanjia Yu, Minjie Wang, Xiaoli Lv, Jun Li, Tuya Bai, Fuhou Chang   +10 more
doaj   +1 more source

AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia

International Journal of Cell Biology, 2023
The role of hypoxia in benign meningiomas is less clear than that in the malignant meningiomas. Hypoxia-induced transcription factor 1 subunit alpha (HIF-1α) and its downstream signaling pathways play a central role in the mechanism of hypoxia.
Maria L. Perepechaeva, Lyubov S. Klyushova, Alevtina Y. Grishanova   +2 more
doaj   +1 more source