Results 91 to 100 of about 44,282 (308)

Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis

, 2022
Guillermo Solís‐Fernández, Ana Montero‐Calle, Maricruz Sánchez-Martínez, Alberto Peláez‐García, María Jesús Fernández‐Aceñero, Pilar Pallarés, Miren Alonso‐Navarro, Marta Mendiola, Jelle Hendrix, David Hardisson, Rubén A. Bartolomé, Johan Hofkens, Susana Rocha, Rodrigo Barderas   +13 more
openalex   +2 more sources

Bupi Yishen formula attenuates kidney injury in 5/6 nephrectomized rats via the tryptophan-kynurenic acid-aryl hydrocarbon receptor pathway [PDF]

, 2021
Yenan Mo, Xina Jie, Lixin Wang, Chunlan Ji, Yue-Yu Gu, Zhaoyu Lu, Xusheng Liu   +6 more
openalex   +1 more source

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice

iMetaOmics, EarlyView.
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the elevated levels of 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) activated the hepatic aryl hydrocarbon receptor (AhR) and subsequently promoted insulin‐like ...
Yongmei Yang, Jing Yang, Weiyao Zhang, Linghao Zhou, Chenxu Zhu, Xuguang Zhang, Yuejian Mao, Meiling Zhang   +7 more
wiley   +1 more source

Evaluating the Endocrine‐Disrupting and Oxidative Stress Potential of a 50‐Component Human‐Relevant Complex Chemical Mixture Using In Vitro Tests

Journal of Applied Toxicology, EarlyView.
ABSTRACT Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine‐disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine‐disruptive and oxidative stress potential of a human‐relevant, complex chemical mixture in vitro.
Josefin Engelhardt, Nathalie Struwe, Annika Jansson, Vesna Munic Kos, Maria Larsson, Jana M. Weiss   +5 more
wiley   +1 more source

Insulin/insulin like growth factors in cancer: new roles for the aryl hydrocarbon receptor, tumor resistance mechanisms and new blocking strategies

Frontiers in Endocrinology, 2015
The insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor (IR) are receptor tyrosine kinases (RTKs) that are expressed in cancer cells. The results of different studies indicate that tumor proliferation and survival is dependent on the ...
Travis B Salisbury, Justin K Tomblin
doaj   +1 more source

Thrombin-Induced Microglia Activation Modulated through Aryl Hydrocarbon Receptors. [PDF]

Int J Mol Sci, 2023
Sheu ML, Pan LY, Yang CN, Sheehan J, Pan LY, You WC, Wang CC, Pan HC.   +7 more
europepmc   +1 more source

Supplementary Figure 3 from A Novel Compound, NK150460, Exhibits Selective Antitumor Activity against Breast Cancer Cell Lines through Activation of Aryl Hydrocarbon Receptor

, 2023
Kazuteru Fukasawa, Shigehide Kagaya, Sakiko Maruyama, Shunsuke Kuroiwa, Kuniko Masuda, Yoshio Kameyama, Yoshitaka Satoh, Yuichi Akatsu, Arihiro Tomura, Kiyohiro Nishikawa, Shigeo Horie, Yuh-ichiro Ichikawa   +11 more
openalex   +1 more source

Deletion of the Aryl Hydrocarbon Receptor-associated Protein 9 Leads to Cardiac Malformation and Embryonic Lethality*

Journal of Biological Chemistry, 2007
The aryl hydrocarbon receptor-associated protein 9, ARA9 (also known as XAP2 or AIP1), is a chaperone that is found in complexes with certain xenobiotic receptors, such as the aryl hydrocarbon receptor (AHR) and the peroxisome proliferator-activated ...
Bernice C. Lin, R. Sullivan, Youngsook Lee, S. Moran, E. Glover, C. Bradfield   +5 more
semanticscholar   +1 more source

Occupational Exposure to Factory‐Derived Particulate Matter 2.5 Induces Cutaneous Toxicity in Workers and HaCaT Keratinocytes Through Oxidative Stress and Inflammation

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate the toxicological effects of occupational exposure to factory‐derived particulate matter (PM2.5) on human skin, emphasizing its role as a potential target organ of environmental toxicants. An epidemiological survey comparing factory and nonfactory workers was conducted by assessing their skin elasticity and color ...
Miku Tanaka, Masayuki Takaishi, Iroha Okuda, Toshiki Fujimoto, Mayumi Tsuji, Yuri Okano, Yasuhiro Ishihara, Maori Kono   +7 more
wiley   +1 more source

Role of Mediator in Transcriptional Activation by the Aryl Hydrocarbon Receptor*

Journal of Biological Chemistry, 2004
The aryl hydrocarbon receptor (AHR) binds many aromatic hydrocarbon compounds and mediates their carcinogenesis. We demonstrate that the endogenous AHR physically associates with the endogenous TRAP/DRIP/ARC/Mediator complex in a ligand-dependent manner.
Song Wang, K. Ge, R. Roeder, O. Hankinson   +3 more
semanticscholar   +1 more source