Results 81 to 90 of about 19,957 (224)

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Insulin/insulin like growth factors in cancer: new roles for the aryl hydrocarbon receptor, tumor resistance mechanisms and new blocking strategies

Frontiers in Endocrinology, 2015
The insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor (IR) are receptor tyrosine kinases (RTKs) that are expressed in cancer cells. The results of different studies indicate that tumor proliferation and survival is dependent on the ...
Travis B Salisbury, Justin K Tomblin
doaj   +1 more source

Substituted Two- to Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a. [PDF]

Environ Sci Technol, 2021
Lille-Langøy R, Jørgensen KB, Goksøyr A, Pampanin DM, Sydnes MO, Karlsen OA.   +5 more
europepmc   +1 more source

Associations of Outdoor Air Pollution With Incidence of Cancers Other Than Lung Cancer in a Large US Prospective Cohort

International Journal of Cancer, EarlyView.
Associations between outdoor air pollution and cancers other than lung cancer remain unclear, particularly in the context of tobacco use. Here, the authors assessed possible links between ambient air pollutant exposure and incidence of 20 non‐lung cancers among adults followed over a 25‐year period in the United States.
W. Ryan Diver, Lauren R. Teras, Emily L. Deubler, Alpa V. Patel, Michelle C. Turner   +4 more
wiley   +1 more source

Aryl hydrocarbon receptor-regulated long non-coding RNAs: implications for glycolipid metabolism and prognosis in hepatocellular carcinoma

Frontiers in Oncology
BackgroundHepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths with limited treatment options. Tumor metabolic disorder is elevated in HCC and activates the aryl hydrocarbon receptor (AHR), a transcription factor implicated in ...
Xiaoli Xiao, Yao Liu, Xiaoyong Qu, Logen Liu, Guo-Qing Li, Honghui Chen, Linlin Zhou, Yanping Liu   +7 more
doaj   +1 more source

Gut Microbiota-Derived Indole-3-Carboxylate Influences Mucosal Integrity and Immunity Through the Activation of the Aryl Hydrocarbon Receptors and Nutrient Transporters in Broiler Chickens Challenged With Eimeria maxima. [PDF]

Front Immunol, 2022
Park I, Nam H, Goo D, Wickramasuriya SS, Zimmerman N, Smith AH, Rehberger TG, Lillehoj HS.   +7 more
europepmc   +1 more source

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

iMeta, EarlyView.
Clostridium scindens and its metabolite indole‐3‐acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stability and produces IAA via its own amidase (AMIE) and aldehyde dehydrogenase (ALDH), thus promoting intestinal homeostasis by activating the aryl hydrocarbon ...
Wei‐Chuan Lin, Cui Zhang, He‐Hua Lei, Zheng Cao, Xin Gao, Wen‐Kai Yu, Xin‐Zhi Li, Qing‐Wei Xiang, Zhi‐Wen Zhang, Shi‐Fu Pang, Wei‐Fei Luo, Deng‐Hui Xie, Li‐Min Zhang, Gang Chen   +13 more
wiley   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source