Metformin reverses development of pulmonary hypertension via aromatase inhibition [PDF]
, 2016 Females are more susceptible to pulmonary arterial hypertension than males, although the reasons remain unclear. The hypoglycemic drug, metformin, is reported to have multiple actions, including the inhibition of aromatase and stimulation of AMP ...
Dean, Afshan +4 more
core +2 more sources
Kynurenine pathway metabolism and the microbiota-gut-brain axis [PDF]
, 2018 It has become increasingly clear that the gut microbiota influences not only gastrointestinal physiology but also central nervous system (CNS) function by modulating signalling pathways of the microbiota-gut-brain axis.
Clarke, Gerard +3 more
core +1 more source
Systems Biology of Gut Microbiota-Human Receptor Interactions: Toward Anti-inflammatory Probiotics
Frontiers in Microbiology, 2022 The incidence and prevalence of inflammatory disorders have increased globally, and is projected to double in the next decade. Gut microbiome-based therapeutics have shown promise in ameliorating chronic inflammation.
Lokanand Koduru +7 more
doaj +1 more source
Signaling in a polluted world: oxidative stress as an overlooked mechanism linking contaminants to animal communication [PDF]
, 2016 The capacity to communicate effectively with other individuals plays a critical role in the daily life of an individual and can have important fitness consequences.
Costantini, David, Marasco, Valeria
core +1 more source
Microbial carcinogenic toxins and dietary anti-cancer protectants [PDF]
, 2017 Several toxins are known which account for the ability of some bacteria to initiate or promote carcinogenesis. These ideas are summarised and evidence is discussed for more specific mechanisms involving chymotrypsin and the bacterial chymotryptic enzyme ...
Darlington, L. Gail, Stone, Trevor W.
core +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Frontiers in Immunology, 2023 Dendritic cells (DCs) are mediators between innate and adaptive immunity and vital in initiating and modulating antigen-specific immune responses. The most important site for induction of tolerance is the gut mucosa, where TGF-β, retinoic acid, and aryl ...
Gillian Dao Nyesiga +10 more
doaj +1 more source
A tripartite of immune-, epithelial-, and nervous-systems in the homeostatic regulation of the gut [PDF]
, 2016 Various cell types in the intestinal mucosa are constantly exposed to complex signals emanating from the lumen, including the microbiota and its metabolites.
Chng, Song Hui
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]
, 2017 It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co ...
Indarto, Dono, Izawa, Masao
core