Results 251 to 260 of about 44,282 (308)

The Aryl Hydrocarbon Receptor Complex

Annual Review of Pharmacology and Toxicology, 1995
The heteromeric unliganded aryl hydrocarbon receptor complex (AHRC) contains the aryl hydrocarbon receptor monomer (AHR). Binding of polycyclic or halogenated aromatic hydrocarbon (PAH and HAH) ligand causes release of AHR, which then associates with the AHR nuclear translocator protein (ARNT) to generate the heterodimeric "transformed" AHRC.
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The aryl hydrocarbon receptor in immunity

Trends in Immunology, 2009
Low-molecular-weight chemicals or xenobiotics might contribute to the increasing prevalence of allergies and autoimmunity. Certain chemicals can alter immune responses via their action on the cytosolic transcription factor aryl hydrocarbon receptor (AhR).
Charlotte, Esser, Agneta, Rannug, Brigitta, Stockinger   +2 more
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Aryl hydrocarbon receptor and unexplained miscarriage

Journal of Obstetrics and Gynaecology Research, 2017
AbstractAimThe aim of this study was to carry out a preliminary investigation of the expression of aryl hydrocarbon receptor (AhR) in decidua and villus and the relationship between AhR and unexplained miscarriage.MethodsThe expression of AhR mRNA and protein from decidua and villus were measured using real‐time reverse transcription–polymerase chain ...
Hongjie, Fan, Xiaoling, Su, Binlie, Yang, Aimin, Zhao   +3 more
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The aryl hydrocarbon receptor and light

Biological Chemistry, 2006
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been intensively studied with respect to the toxicity of xenobiotics. However, its function in response to light has never been summarized. Here, we provide an overview of AhR activation by light with a focus on the role of tryptophan in light-induced AhR activation.
Agneta, Rannug, Ellen, Fritsche
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Aryl Hydrocarbon Receptor-Mediated Signal Transduction

Critical Reviews in Toxicology, 1997
The aryl hydrocarbon (or dioxin) receptor (AhR) is a ligand-activated basic helix-loop-helix (bHLH) protein that heterodimerizes with the bHLH protein ARNT (aryl hydrocarbon nuclear translocator) forming a complex that binds to xenobiotic regulatory elements in target gene enhancers.
J C, Rowlands, J A, Gustafsson
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Identification of functional aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator in murine splenocytes

Biochemical Pharmacology, 1996
The objective of the present studies was to determine whether the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) protein are present and functional in B6C3F1 (C57BL/6 x C3H) mouse splenocytes. Northern analysis of poly(A) RNA isolated from splenocytes revealed transcripts of approximately 6.6 kb which hybridized to the AhR ...
C E, Williams, R B, Crawford, M P, Holsapple, N E, Kaminski   +3 more
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Expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocators in human adenoid tissue

Auris Nasus Larynx, 2011
The aim of this study was to determine whether aryl hydrocarbon receptor (AhR) and AhR nuclear translocators (ARNTs) are expressed in human adenoid tissue.Paraffin-embedded human adenoid tissue specimens were obtained from eight children with adenoid hypertrophy.
Kazuhiko, Kubo, Mio, Sakaki, Mitsuru, Ohashi, Shizuo, Komune   +3 more
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IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor

Nature Immunology, 2021
Yuying Liu, Nannan Zhou, L. Zhou, Jing Wang, Yabo Zhou, Tianzhen Zhang, Yiliang Fang, Jin-feng Deng, Yunfeng Gao, Xiaoyu Liang, Jiadi Lv, Zhenfeng Wang, Jing Xie, Yuanbo Xue, Huafeng Zhang, Jingwei Ma, K. Tang, Yiliang Fang, Feiran Cheng, Chengjuan Zhang, B. Dong, Yuzhou Zhao, P. Yuan, Quanli Gao, Haizeng Zhang, F. Xiao-Feng Qin, Bo Huang   +26 more
semanticscholar   +1 more source

Nucleocytoplasmic Shuttling of the Aryl Hydrocarbon Receptor

Journal of Biochemistry, 2000
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that acts in concert with the AhR nuclear translocator (ARNT), and alters gene expression in response to environmental contaminants such as 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD).
T, Ikuta, T, Tachibana, J, Watanabe, M, Yoshida, Y, Yoneda, K, Kawajiri   +5 more
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The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action

Trends in Endocrinology & Metabolism, 1994
The aryl hydrocarbon (AH, or dioxin) receptor mediates carcinogenesis by a wide variety of compounds. It acts as a ligand-dependent transcription factor. Many investigators expected that the AH receptor would prove to be a member of the steroid/thyroid/retinoic acid receptor superfamily of proteins.
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