Frontiers in Physiology, 2015 The evolution of N-acetyltransfeases (NATs) seems complex. Vertebrate arylalkylamine N-acetyltransferase (aaNAT) has been extensively studied since it Leads to the synthesis of melatonin, a multifunctional neurohormone prevalent in photoreceptor cells ...
Susumu eHiragaki +3 more
doaj +1 more source
N-acetyltransferase 2 (NAT2) Gene Polymorphisms and the Effectiveness of Infertility Treatment in Patients with Peritoneal Endometriosis [PDF]
, 2014 Today, infertility has become a global issue. WHO ranks it the fifth among the major diseases of those below 60 years, after alcoholism, depression, injuries and eyesight disorders.
Alexander S. Gasparov +3 more
core
Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis
Sultan Qaboos University Medical Journal, 2003 Objective: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Method: Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A ...
Musbah O. M. Tanira +5 more
doaj
Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort. [PDF]
, 2019 While disparity in pancreatic cancer incidence between blacks and whites has been observed, few studies have examined disparity in other ethnic minorities. We evaluated variations in pancreatic cancer incidence and assessed the extent to which known risk
Haiman, Christopher A +8 more
core +1 more source
Kinetic characterisation of arylamine N-acetyltransferase from Pseudomonas aeruginosa [PDF]
BMC Biochemistry, 2007 Arylamine N-acetyltransferases (NATs) are important drug- and carcinogen-metabolising enzymes that catalyse the transfer of an acetyl group from a donor, such as acetyl coenzyme A, to an aromatic or heterocyclic amine, hydrazine, hydrazide or N-hydroxylamine acceptor substrate.
Westwood, Isaac M, Sim, Edith
openaire +2 more sources
Frequency of NAT2 and GSTP1 polymorphisms in the Kazakh population
Central Asian Journal of Global Health, 2014 Introduction: Phase II xenobiotic biotransformation enzymes perform detoxification of hydrophilic and often toxic Phase I products by glutathionetransferase (GST), UDP-glucuronosyltransferase (UDF), N-acetyltransferase (NAT) families and other enzymes ...
Aisha Iskakova +4 more
doaj +1 more source
Estimation of N-acetyltransferase 2 haplotypes [PDF]
N-Acetyltransferase 2 (NAT2) genotyping may result in a considerable percentage in several ambiguous allele combinations. PHASE 2.1 is a statistical program which is designed to estimate the probability of different allele combinations.
Blaszkewicz, Meinolf +5 more
core
Polymorphism Analysis of Genes Involved in Xenobiotic Metabolism and Circadian Rhythm in Human Breast Cancer [PDF]
, 2013 Individual response to xenobiotic exposures depends on the dynamics of xenobiotic metabolism and the circadian clock system, among other factors.
Cerliani, María Belén +1 more
core +1 more source
Carcinogen metabolism, cigarette smoking, and breast cancer risk: a Bayes model averaging approach [PDF]
, 2010 BACKGROUND: Standard logistic regression with or without stepwise selection has the disadvantage of not incorporating model uncertainty and the dependency of estimates on the underlying model into the final inference.
Jenny Chang-Claude +2 more
core +2 more sources
Kinetic characterization of arylamine N‐acetyltransferase 2
The FASEB Journal, 2008 N‐acetyltransferase 2 (NAT 2) is an enzyme that catalyzes the acetylation of harmful arylamines and has been implicated in various types of cancer. NAT 2 is primarily expressed in the hepatic system and intestinal epithelium and is encoded at two polymorphic loci that give the phenotypic characteristics of slow and fast acetylation.
Inesha Baker, Chasta L Parker
openaire +1 more source