Results 111 to 120 of about 17,285 (228)
Toxicology Reports, 2022 Previous studies have shown that inhibition or depletion of N-acetyltransferase 1 (NAT1) in breast cancer cell lines leads to growth retardation both in vitro and in vivo, suggesting that NAT1 contributes to rapid growth of breast cancer cells.
Kyung U. Hong +8 more
doaj
Frequency of NAT2 and GSTP1 polymorphisms in the Kazakh population
Central Asian Journal of Global Health, 2014 Introduction: Phase II xenobiotic biotransformation enzymes perform detoxification of hydrophilic and often toxic Phase I products by glutathionetransferase (GST), UDP-glucuronosyltransferase (UDF), N-acetyltransferase (NAT) families and other enzymes ...
Aisha Iskakova +4 more
doaj +1 more source
N-acetyltransferase 2 (NAT2) Gene Polymorphisms and the Effectiveness of Infertility Treatment in Patients with Peritoneal Endometriosis [PDF]
, 2014 Today, infertility has become a global issue. WHO ranks it the fifth among the major diseases of those below 60 years, after alcoholism, depression, injuries and eyesight disorders.
Alexander S. Gasparov +3 more
core
Annals of Hepatology, 2020 Introduction and objective: Hepatotoxicity during tuberculosis (TB) treatment is frequent and may be related to the Arylamine N-Acetyltransferase (NAT2) acetylator profile, in which allele frequencies differ according to the population.
Carolline Araujo-Mariz +8 more
doaj
Estimation of N-acetyltransferase 2 haplotypes [PDF]
N-Acetyltransferase 2 (NAT2) genotyping may result in a considerable percentage in several ambiguous allele combinations. PHASE 2.1 is a statistical program which is designed to estimate the probability of different allele combinations.
Blaszkewicz, Meinolf +5 more
core
Arylamine N-acetyltransferases: Structural and functional implications of polymorphisms
Toxicology, 2008 Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines, arylhydroxylamines and arylhydrazines with the acetyl group being transferred from acetylCoenzyme A. As a result of many recent advances in NAT research there have been many recent reviews and the present paper gives a flavour of the excitement in the field. The NATs, which
Sim, Edith +6 more
openaire +4 more sources
Acetylator Genotype-Dependent Dyslipidemia in Rats Congenic for N-Acetyltransferase 2
Toxicology Reports, 2020 Recent reports suggest that arylamine N-acetyltransferases (NAT1 and/or NAT2) serve important roles in regulation of energy utility and insulin sensitivity. We investigated the interaction between diet (control vs. high-fat diet) and acetylator phenotype
Kyung U. Hong +10 more
doaj
CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis [PDF]
, 2018 Objective: To determine whether pharmacogenetic tests such as N-acetyltransferase 2 (NAT2) and cytochrome P4502E1 (CYP2E1) genotyping are useful in identifying patients prone to antituberculosis drug-induced hepatotoxicity in a cosmopolite population ...
Chiappe, Alberto +8 more
core
Investigation of human n-acetyltransferases (NAT1 and NAT2) genetic polymorphisms in susceptibility to aromatic amine and alkylaniline genotoxicity. [PDF]
, 2022 Arylamine N-acetyltransferases, NAT1 and NAT2, catalyze the detoxification and/or activation of carcinogens. Single nucleotide polymorphisms or SNPs result in different human NAT1 and NAT2 genotypes. We hypothesize that different NATs alleles will impact
Habil, Mariam Refaat Zaky
core +1 more source
An approach to identifying novel substrates of bacterial arylamine N -acetyltransferases
Bioorganic & Medicinal Chemistry, 2003 Arylamine N-acetyltransferases (NATs) catalyse the acetylation of arylamine, arylhydrazine and arylhydroxylamine substrates by acetyl Coenzyme A. NAT has been discovered in a wide range of eukaryotic and prokaryotic species. Although prokaryotic NATs have been implicated in xenobiotic metabolism, to date no endogenous role has been identified for the ...
Brooke, E +5 more
openaire +3 more sources