Results 121 to 130 of about 17,285 (228)

Status Asetilator Gen NAT2 pada Pasien Tuberkulosis dan Tuberkulosis dengan Diabetes Melitus di Kupang, Nusa Tenggara Timur

Majalah Kedokteran Bandung, 2017
Indonesia is the second highest country with TB patients in the world. Diabetes mellitus (DM) is a comorbid of TB. Arylamine N-acetyltransferase 2 (NAT2), encoded by the NAT2 gene, is an enzyme that metabolizes isoniazid (INH).
Alvinsyah Adhityo Pramono, Simeon Penggoam, Edhyana Sahiratmadja, Novi Vicahyani Utami, Tri Hanggono Achmad, Ramdan Panigoro   +5 more
doaj   +1 more source

Interethnic diversity of NAT2 polymorphisms in Brazilian admixed populations [PDF]

, 2010
Background N-acetyltransferase type 2 (Nat2) is a phase II drug- metabolizing enzyme that plays a key role in the bioactivation of aromatic and heterocyclic amines.
Correa, Ronan X, Di Pietro, Giuliano, Magno, Luiz Alexandre V, Melo, Paulo RS, Rios-Santos, Fabrício, Santana, Cinthia VN, Sousa, Sandra MB, Talbot, Jhimmy   +7 more
core   +3 more sources

Eukaryotic arylamine N-acetyltransferase

Biochemical Pharmacology, 2005
Arylamine N-acetyltransferases (NAT; EC 2.3.1.5) catalyse the transfer of acetyl groups from acetylCoA to xenobiotics, including drugs and carcinogens. The enzyme is found extensively in both eukaryotes and prokaryotes, yet the endogenous roles of NATs are still unclear. In order to study the properties of eukaryotic NATs, high-throughput substrate and
Kawamura, A, Graham, J, Mushtaq, A, Tsiftsoglou, SA, Vath, G, Hanna, P, Wagner, C, Sim, E   +7 more
openaire   +4 more sources

NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant

BMC Medical Genetics, 2004
Background Alzheimer's disease is multifactorial, having environmental, toxicological and genetic risk factors. Impaired folate and homocysteine metabolism has been hypothesised to increase risk. In addition to its xenobiotic-metabolising capacity, human
Budge Marc, Jonovska Vesna, Bell Peter, Johnson Nichola, Sim Edith   +4 more
doaj   +1 more source

Heterocyclic amines and arylamine N-acetyltransferase 2 polymorphism in pathogenesis of insulin resistance. [PDF]

, 2021
Heterocyclic amines (HCAs) are formed when cooking meats at high temperatures or for long periods of time, and their major metabolic pathway includes hepatic N‑hydroxylation by CYP1A2 followed by O-acetylation by N-acetyltransferase 2 (NAT2).
Walls, Kennedy M
core   +1 more source

Role of human arylamine n-acetyltransferase 1 in tumorigenesis and cancer biology. [PDF]

, 2017
Human arylamine N-acetyltransferase 1 (NAT1) is a well-known phase II metabolic enzyme that has been associated with carcinogenesis. Its role in the biotransformation of aromatic and heterocyclic amine carcinogens has been investigated for many years ...
Stepp, Marcus William
core   +1 more source

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase

Protein Expression and Purification, 2003
Arylamine N-acetyltransferase (NAT) acetylates the front-line anti-tuberculosis drug isoniazid (INH) and has been identified in Mycobacterium tuberculosis. A naturally occurring single nucleotide polymorphism (SNP) was recently found in the NAT gene in clinical isolates of M. tuberculosis.
Kawamura A, Sandy J, Upton A, Noble M, Sim E   +4 more
openaire   +5 more sources

Pharmacokinetics of isoniazid and rifapentine in young pediatric patients with latent tuberculosis infection

International Journal of Infectious Diseases, 2022
Objectives: This study investigated the steady-state pharmacokinetic profiles of 3-month weekly rifapentine plus isoniazid (3HP) in children with latent tuberculosisinfection (LTBI).
Weeraya Phaisal, Watsamon Jantarabenjakul, Noppadol Wacharachaisurapol, Monta Tawan, Thanyawee Puthanakit, Supeecha Wittayalertpanya, Pajaree Chariyavilaskul   +6 more
doaj  

Breast Cancer and Active and Passive Smoking: The Role of the N-Acetyltransferase 2 Genotype [PDF]

, 2017
The association of breast cancer with passive and active smoking was investigated in slow and fast acetylators of aromatic amines in a Geneva, Switzerland, study in 1996-1997.
Bernstein, M. S., Bouchardy, I., Kurtz, J., Morabia, A., Morris, M. A.   +4 more
core  

Deletion of the benzoxazinoid detoxification gene NAT1 in Fusarium graminearum reduces deoxynivalenol in spring wheat.

PLoS ONE, 2019
Benzoxazinoid (Bx) metabolites produced by wheat and other members of the Poaceae have activity against Fusarium sp. that cause cereal diseases including Fusarium head blight (FHB) on wheat and barley. Certain Bx metabolites can be detoxified by Fusarium
Thomas Baldwin, Suzette Baldwin, Kathy Klos, Phil Bregitzer, Juliet Marshall   +4 more
doaj   +1 more source