Inducible tumor difference between rapid and slow rat Nat2 congenic Fischer 344 rats administered methyl-nitrosourea. [PDF]
, 2014 Human arylamine N-acetyltransferase 1 (NAT1) is a well-known phase II metabolic enzyme that has been associated with carcinogenesis. Its role in the biotransformation of aromatic and heterocyclic amine carcinogens has been investigated for many years ...
Stepp, Marcus W.
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Two arylamine N‐acetyltransferases from chicken pineal gland as identified by cDNA cloning [PDF]
, 1989 Michiko Ohtomi +2 more
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Role of human arylamine N-acetyltransferase in carcinogen metabolism and human breast cancer progression. [PDF]
, 2012 Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and ...
Leggett, Carmine Simone
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Purification and properties of the enzyme arylamine N-acetyltransferase from the housefly Musca domestica [PDF]
, 1993 David P. Whitaker, Michael W. Goosey
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Investigations of N-acetyltransferases in human hepatocytes and rat models. [PDF]
, 2005 This thesis begins by reviewing human N-acetyltransferases (Chapter I), then outlines experiments involving human hepatocytes and rat N-acetyltransferases (Chapters II-V).
Walraven, Jason Matthew
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Functional effects of CYP1A2, NAT1, and NAT2 genetic variants in nucleotide excision repair-deficient human fibroblasts : implications for toxicological risk from environmental arylamines. [PDF]
, 2010 Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the detoxification and/or activation of aromatic and heterocyclic amine carcinogens by two pathways. This metabolism reaction can lead to the detoxification by Nacetylation, or bioactivation by
Leggett, Carmine Simone
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Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells [PDF]
, 1995 Rodney F. Minchin
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Mapping the genes for arylamine N-acetyltransferases
, 2000 Arylamine N-acetyltransferases are xenobiotic metabolising enzymes, involved in metabolic pathways leading to either detoxification or bio-activation of drugs and carcinogens. In humans, polymorphisms of the two functional NAT genes (NAT1 and NAT2} have been implicated to cancer susceptibility.
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Increased frequency of wild-type arylamine-N-acetyltransferase allele NAT2*4 homozygotes in Portuguese patients with colorectal cancer [PDF]
, 1998 José Pedro Gil
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Dataset for proteomic analysis of arylamine N-acetyltransferase 1 knockout MDA-MB-231 breast cancer cells. [PDF]
Data Brief, 2022 Hong KU +8 more
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