Results 151 to 160 of about 13,476,144 (183)

Arylamine N-acetyltransferases: From Structure to Function

Drug Metabolism Reviews, 2008
Arylamine N-acetyltransferases (NATs) are cytosolic conjugating enzymes which transfer an acetyl group from acetylCoenzyme A to a xenobiotic acceptor substrate. The enzyme has an active site cysteine as part of a catalytic triad with histidine and aspartate. NATs have had an important role in pharmacogenetics.
Edith, Sim, Kylie, Walters, Sotiria, Boukouvala   +2 more
openaire   +2 more sources

Identification and Characterization of Functional Rat Arylamine N-Acetyltransferase 3: Comparisons with Rat Arylamine N-Acetyltransferases 1 and 2

The Journal of Pharmacology and Experimental Therapeutics, 2006
Arylamine N-acetyltransferases (NATs; EC 2.3.1.5) catalyze both the N-acetylation and O-acetylation of arylamines and N-hydroxyarylamines. Humans possess two functional N-acetyltransferase genes, NAT1 and NAT2, as well as a nonfunctional pseudogene, NATP. Previous studies have identified Nat1 and Nat2 genes in the rat.
Jason M, Walraven, Mark A, Doll, David W, Hein   +2 more
openaire   +2 more sources

Arylamine N‐Acetyltransferase in Erythrocytes of Cystic Fibrosis Patients

Pharmacology & Toxicology, 1996
Abstract:Sulphamethoxazole, a substrate of human arylamine N‐acetyltransferase, is used in the treatment of cystic fibrosis patients, who metabolise the drug rapidly. Increased metabolic clearance of sulphamethoxazole has been suggested to account for this rapid metabolism.
A, Risch, V, Smelt, D, Lane, L, Stanley, W, van der Slot, A, Ward, E, Sim   +6 more
openaire   +2 more sources

Evidence for arylamine N-acetyltransferase in the nematode Anisakis simplex

Cancer Letters, 1996
N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography.
J G, Chung, H M, Kuo, T H, Lin, C C, Ho, J H, Lee, J M, Lai, G N, Levy, W W, Weber   +7 more
openaire   +2 more sources

Arylamine N-acetyltransferase (NAT2) genotypes in a Turkish population

Pharmacogenetics, 1997
A group of 303 unrelated Turkish subjects from south-east Anatolia was genotyped for seven NAT2 mutations by polymerase chain reaction-restriction fragment length polymorphism. Genotypes associated with slow acetylation were identified in 57.4% (95%-confidence limits, 51.6%-63.1%).
A S, Aynacioglu, I, Cascorbi, P M, Mrozikiewicz, I, Roots   +3 more
openaire   +2 more sources

Arylamine N-Acetyltransferases

2018
N. Laurieri, E. Polycarpou, E. Sim
openaire   +1 more source

Arylamine N-Acetyltransferases

2008
Butcher, Neville J., Minchin, Rodney F.
openaire   +3 more sources

Pharmacogenomics of Arylamine N-acetyltransferase

Current Pharmacogenomics, 2004
Adeel Mushtaq, Matthew Anderton, Valerie Cornish   +2 more
openaire   +1 more source

Arylamine N-acetyltransferase

1996
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Eukaryotic arylamine N-acetyltransferase

Biochemical Pharmacology, 2005
Akane Kawamura, James Graham, Adeel Mushtaq, Stefanos A. Tsiftsoglou, Gregory M. Vath, Patrick E. Hanna, Carston R. Wagner, Edith Sim   +7 more
openaire   +1 more source