Results 161 to 170 of about 2,402 (195)

Insights into the Phylogeny or Arylamine N-Acetyltransferases in Fungi

Journal of Molecular Evolution, 2010
Previous studies have shown that Eumycetes fungi can acylate arylamine thanks to arylamine N-acetyltransferases, xenobiotic-metabolizing enzymes also found in animals and bacteria. In this article, we present the results of mining 96 available fungal genome sequences for arylamine N-acetyltransferase genes and propose their phylogeny.
Marta, Martins, Julien, Dairou, Fernando, Rodrigues-Lima, Jean-Marie, Dupret, Philippe, Silar   +4 more
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Arylamine N-acetyltransferases – of mice, men and microorganisms

Trends in Pharmacological Sciences, 2001
Arylamine N-acetyltransferases (NATs) catalyse the transfer of an acetyl group from acetyl CoA to the terminal nitrogen of hydrazine and arylamine drugs and carcinogens. These enzymes are polymorphic and have an important place in the history of pharmacogenetics, being first identified as responsible for the polymorphic inactivation of the anti ...
A, Upton, N, Johnson, J, Sandy, E, Sim
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Identification and Characterization of Functional Rat Arylamine N-Acetyltransferase 3: Comparisons with Rat Arylamine N-Acetyltransferases 1 and 2

The Journal of Pharmacology and Experimental Therapeutics, 2006
Arylamine N-acetyltransferases (NATs; EC 2.3.1.5) catalyze both the N-acetylation and O-acetylation of arylamines and N-hydroxyarylamines. Humans possess two functional N-acetyltransferase genes, NAT1 and NAT2, as well as a nonfunctional pseudogene, NATP. Previous studies have identified Nat1 and Nat2 genes in the rat.
Jason M, Walraven, Mark A, Doll, David W, Hein   +2 more
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Arylamine N-acetyltransferase (NAT2) genotypes in a Turkish population

Pharmacogenetics, 1997
A group of 303 unrelated Turkish subjects from south-east Anatolia was genotyped for seven NAT2 mutations by polymerase chain reaction-restriction fragment length polymorphism. Genotypes associated with slow acetylation were identified in 57.4% (95%-confidence limits, 51.6%-63.1%).
A S, Aynacioglu, I, Cascorbi, P M, Mrozikiewicz, I, Roots   +3 more
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Evidence for arylamine N-acetyltransferase in the nematode Anisakis simplex

Cancer Letters, 1996
N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography.
J G, Chung, H M, Kuo, T H, Lin, C C, Ho, J H, Lee, J M, Lai, G N, Levy, W W, Weber   +7 more
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Evidence for Arylamine N-Acetyltransferase Activity in the Escherichia coli

Current Microbiology, 1998
N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene as substrates were determined in isolates of the bacterium Escherichia coli. The N-acetyltransferase activity was determined by an acetyl CoA recycling assay and high pressure liquid chromatography. The N-acetyltransferase activities from a number of E. coli isolates were found
F C, Chang, J G, Chung
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Pharmacogenomics of Arylamine N-acetyltransferase

Current Pharmacogenomics, 2004
Adeel Mushtaq, Matthew Anderton, Valerie Cornish   +2 more
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Arylamine N-Acetyltransferases

2018
N. Laurieri, E. Polycarpou, E. Sim
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Arylamine N-Acetyltransferases

2008
Butcher, Neville J., Minchin, Rodney F.
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Eukaryotic arylamine N-acetyltransferase

Biochemical Pharmacology, 2005
Akane Kawamura, James Graham, Adeel Mushtaq, Stefanos A. Tsiftsoglou, Gregory M. Vath, Patrick E. Hanna, Carston R. Wagner, Edith Sim   +7 more
openaire   +1 more source