Results 111 to 120 of about 22,861 (258)

Ullmann‐Type N‐Heteroarylation of Nitrogen Heterocycles Catalyzed by Heterogeneous CuNPs/HKUST‐1

EcoEnergy, EarlyView.
A practical strategy for the direct synthesis of CuNPs/HKUST‐1 heterogeneous catalyst was developed and used for the catalyzing Ullmann‐type N‐arylation of N‐heterocycles with high yields, excellent recyclability, and low copper leaching. ABSTRACT Ullmann‐type C–N coupling is an essential reaction to construct functional nitrogen heterocycles, whereas ...
Shuai Yang, Fangshu Han, Yamin Dong, Liangting Wu, Wenchao Tang, Changyan Guo, Jide Wang, Ablimit Abdukader, Chenjiang Liu, Yonghong Zhang   +9 more
wiley   +1 more source

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

European Journal of Organic Chemistry, EarlyView.
Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau, Maxime Riberaud, Frédéric Taran, Antoine Sallustrau   +3 more
wiley   +1 more source

Diastereodivergent Construction of Octahydrophenanthridinone and Octahydrophenanthridine Cores

Molecules
Diastereodivergent synthesis of octahydrophenanthridinone and octahydrophenanthridine skeletons, structural motifs often found in biologically active natural products, is described.
Chunzhao Sun, Hiromichi Nishikawa, Tsubasa Inokuma, Ken-ichi Yamada   +3 more
doaj   +1 more source

Asymmetric Synthesis of Tertiary α‐Aryl Stereocentres in Tetrahydro‐4H‐pyran‐4‐ones Using Pd‐Catalyzed Decarboxylative Asymmetric Protonation

European Journal of Organic Chemistry, EarlyView.
The Pd‐catalyzed decarboxylative asymmetric protonation (DAP) has been developed for sterically hindered tetrahydro‐4H‐pyran‐4‐one derived α‐aryl‐β‐keto esters. A substrate scope of nine examples of DAP showed that substrates containing a di‐ortho methoxy substitution pattern on the aryl ring gave rise to the highest enantioselectivities of up to 85 ...
Fionn McNeill, Joffrey Scriven, Fritz Bahns, Anugam V. Krishna, Julia Bruno‐Colmenarez, Patrick J. Guiry   +5 more
wiley   +1 more source

Synthesis of S‐Arylthioxanthonium Trifluoromethanesulfonates From Thioxanthones and Diaryliodonium Salts by Copper(II) Catalysis and Application to Aryl–Heteroaryl Bond Formation by Direct LED Irradiation

European Journal of Organic Chemistry, EarlyView.
A straightforward Cu(II)‐catalyzed synthesis of S‐arylthioxanthonium trifluoromethanesulfonates from readily available thioxanthones and diaryliodonium salts is described. A broad range of salts is obtained in moderate to good yields. It is further demonstrated that S‐arylthioxanthonium trifluoromethanesulfonates act as aryl radical precursors under ...
Pierre Boulay, Fabrice Morlet‐Savary, Jean‐Michel Becht   +2 more
wiley   +1 more source

Synthesis of benzannelated sultams by intramolecular Pd-catalyzed arylation of tertiary sulfonamides

Beilstein Journal of Organic Chemistry, 2017
A new and efficient approach to five- and six-membered benzannelated sultams by intramolecular C-arylation of tertiary 1-(methoxycarbonyl)methanesulfonamides under palladium catalysis is described.
Valentin A. Rassadin, Mirko Scholz, Anastasiia A. Klochkova, Armin de Meijere, Victor V. Sokolov   +4 more
doaj   +1 more source

Direct Conversion of Aryl Iodides Into Benzylamines by Aminomethylation: Reaction Scope, Mechanistic Studies, and Applications

European Journal of Organic Chemistry, EarlyView.
This study presents an efficient aminomethylation of aryl iodides with formamides for the synthesis of benzylamines using a reusable palladium catalyst at a loading of 65 mol ppm. The substrate scope is systematically evaluated, and mechanistic investigations provide insight into the reaction pathway and the origin of the observed catalytic efficiency.
Abhijit Sen, Atsuya Muranaka, Yu Hatakenaka, Aya Ohno, Yoichi M. A. Yamada   +4 more
wiley   +1 more source

Synthesis of Naphthoquinones by Pd‐Catalyzed Heck–Matsuda Arylation of Lapachol

European Journal of Organic Chemistry, EarlyView.
Direct Heck–Matsuda arylation of lapachol enables the efficient synthesis of diverse naphthoquinones under homogeneous and heterogeneous palladium catalysis. The methodology features broad substrate scope, gram‐scale applicability, and provides a practical platform for quinone diversification.
Breno U. de Abreu, Renata G. Almeida, Ana L. C. Silveira, Leonardo A. Matos, Willian X. C. Oliveira, Maria H. Araujo, Victor F. S. Ramos, Rubem F. S. Menna‐Barreto, Chandrakant B. Nichinde, Felipe Fantuzzi, Edmond Gravel, Eric Doris, Eufrânio N. da Silva Júnior, Guilherme A. M. Jardim   +13 more
wiley   +1 more source

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, EarlyView.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

Selective S-arylation of 2-oxazolidinethiones and selective N-arylation of 2-benzoxazolinones/2-benzimidazolinones

, 2017
Arynes enable highly selective S-arylation and N-arylation.
Lin-Qing Bao, Chu-Han Sun, Rong Lu, Hua-Dong Xu, Mei-Hua Shen, Qing Zhang, Yi Lu   +6 more
core   +1 more source