Results 1 to 10 of about 7,533 (241)
Reevaluation of Serum Arylesterase Activity in Neurodevelopmental Disorders [PDF]
Antioxidants, 2021 Organophosphate compounds (OPs) interfere with neurodevelopment and are neurotoxic for humans and animals. They are first biotransformed to the more toxic oxon form, and then hydrolyzed to specific metabolites by the enzyme paraoxonase/arylesterase ...
Ignazio Stefano Piras +11 more
doaj +6 more sources
Antioxidants, 2020 Background: It has been suggested that circulating Paraoxonase-1 (PON1) and apolipoprotein A1 (APOA1), which closely interacts with the antioxidant enzyme, could be implicated in Alzheimer’s disease (AD) and vascular dementia (VaD) development.
Arianna Romani +6 more
doaj +2 more sources
Lipids in Health and Disease, 2021 Background Recent studies focused on modulating factors of paraoxonase-1 (PON1) activity. In some studies the association between pro-inflammatory markers and PON1 activity was examined, but so far no population-based investigations on this issue have ...
Christa Meisinger +3 more
doaj +2 more sources
Paraoxonase/Arylesterase Activity of Serum Paraoxonase-1 and Schizophrenia: A Systematic Review and Meta-Analysis [PDF]
Antioxidants, 2023 The presence of a pro-oxidant state in patients with schizophrenia may account for the increased risk of atherosclerosis and cardiovascular disease in this group and supports the potential utility of circulating biomarkers of oxidative stress for risk ...
Angelo Zinellu +2 more
doaj +2 more sources
Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma [PDF]
International Journal of Ophthalmology, 2015 AIM:To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation (PEX) syndrome and pseudoexfoliative glaucoma (PEG) and to measure paraoxonase (PON) and arylesterase (ARE) levels.METHODS: A total of 78 ...
Feyza Dursun +7 more
doaj +2 more sources
PON1 and PON3 in Alzheimer’s Disease: Similar Functions but Different Roles [PDF]
AntioxidantsParaoxonase 1 (PON1) and Paraoxonase 3 (PON3) are enzymes located on the surface of high-density lipoprotein (HDL) and share similar antioxidant properties, possibly modulated by other proteins such as Myeloperoxidase (MPO), which drives the shift from ...
Alessandro Trentini +8 more
doaj +2 more sources
Antioxidants, 2023 Exercise may increase the antioxidant capacity of plasma by stimulating antioxidant enzymes. The study aimed to measure the effect of three repetitions of acute exercise on arylesterase (ARE) activity of the paraoxonase 1 (PON1) enzyme.
Aneta Otocka-Kmiecik +6 more
doaj +1 more source
Expression of paraoxonase 1 in HEK293 cells and its effect on lactonase and arylesterase activity in samples containing human serum and/or prooxidant or antioxidant agents - a preliminary study [PDF]
Acta Poloniae Pharmaceutica, 2023 Expression of recombinant paraoxonase 1 (PON1) in the human embryonic kidney (HEK293F) cell line was evaluated. Two recombinant human PON1 proteins were investigated: PON1-Fc, which has an Fc-tag on its C-terminal, and His-PON1-Fc, which has an Fc-tag on
Anna Bizoń, Agnieszka Piwowar
doaj +1 more source
Gomal Journal of Medical Sciences, 2021 Background: Decreased concentration of both oestrogen hormone and vitamin D in postmenopausal period may lead to oxidative stress, lipid peroxidation, dyslipidaemia, osteoporosis, and cardiovascular diseases.
Behic Selman Erdogdu +3 more
doaj +1 more source
Paraoxonase 1 and Chronic Obstructive Pulmonary Disease: A Meta-Analysis
Antioxidants, 2021 Oxidative stress is a driving factor in the pathophysiology of chronic obstructive pulmonary disease (COPD). While paraoxonase 1 (PON1) is an antioxidant enzyme and a potential biomarker of this disease, data regarding the status of PON-1 in COPD are ...
Jun Watanabe +2 more
doaj +1 more source