Results 11 to 20 of about 25,056,579 (316)

Adult metachromatic leukodystrophy: case report

Неврология, нейропсихиатрия, психосоматика, 2021
Metachromatic leukodystrophy (MLD) is a hereditary lysosomal storage disease inherited in an autosomal recessive pattern, which occurs across all age groups.
T. I. Prusova, P. A. Reznichenko, K. D. Yakovleva, D. V. Dmitrenko   +3 more
doaj   +1 more source

Can soil biology tests improve phosphorus and potassium corn fertilizer recommendations?

Agronomy Journal, Volume 114, Issue 6, Page 3457-3472, November/December 2022., 2022
Abstract Integrating soil health (SH) biological properties with soil fertility (SF) evaluations offers a unique opportunity to potentially refine fertilizer recommendations. The objectives of this research included: (a) evaluating current University of Missouri P and K fertilizer recommendations for corn (Zea mays L.) and (b) assess whether SH ...
Jeffrey D. Svedin, Newell R. Kitchen, Curtis J. Ransom, Kristen S. Veum, Stephen H. Anderson   +4 more
wiley   +1 more source

Soil enzyme activities after application of fungicide QuadrisR at increasing concentration rates

Plant, Soil and Environment, 2022
The study aimed to assess the effects of fungicide QuadrisR on activities of soil enzymes contributed to soil nutrient turnover. A batch laboratory experiment with QuadrisR-amended (0 mg/kg ds (dry soil) - 35.00 mg/kg ds) loamy sand soil was conducted ...
Silvena Boteva Boteva, Anelia Evgenieva Kenarova, Michaella Roumenova Petkova, Stela Stoyanova Georgieva, Christo Dimitrov Chanev, Galina Simeonova Radeva   +5 more
doaj   +1 more source

Pseudo arylsulfatase A deficiency Biosynthesis of an abnormal arylsulfatase A [PDF]

FEBS Letters, 1987
Pseudo arylsulfatase A deficiency, an asymptomatic condition, and metachromatic leukodystrophy, a severe neurodegenerative disease, are both associated with profound reductions of arylsulfatase A activity in man. We now report that with metabolic labelling, cultured pseudo deficient cells synthesized about 20% of the normal amount of arylsulfatase A at
Mohammed Ameen, Patricia L. Chang
openaire   +3 more sources

Enantioselective CE–MS analysis of ketamine metabolites in urine

ELECTROPHORESIS, Volume 44, Issue 1-2, Page 125-134, January 2023., 2023
Abstract The chiral drug ketamine has long‐lasting antidepressant effects with a fast onset and is also suitable to treat patients with therapy‐resistant depression. The metabolite hydroxynorketamine (HNK) plays an important role in the antidepressant mechanism of action.
Friederike A. Sandbaumhüter, Jordan T. Aerts, Regula Theurillat, Per E. Andrén, Wolfgang Thormann, Erik T. Jansson   +5 more
wiley   +1 more source

Leukocyte and Dried Blood Spot Arylsulfatase A Assay by Tandem Mass Spectrometry.

Analytical Chemistry, 2020
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay utilizing deuterated natural sulfatide substrate to measure arylsulfatase A (ARSA) activity in leukocytes and dried blood spot (DBS) was developed and validated.
Xinying Hong, A. Kumar, Jessica Daiker, Fan Yi, M. Sadilek, Fabiola De Mattia, F. Fumagalli, Valeria Calbi, Roberta Damiano, M. D. Della Bona, G. la Marca, A. Vanderver, Amy T. Waldman, L. Adang, O. Sherbini, Sarah Woidill, Teryn R. Suhr, J. Kurtzberg, Maria L. Beltran-Quintero, M. Escolar, A. Aiuti, A. Finglas, Amber Olsen, M. Gelb   +23 more
semanticscholar   +1 more source

Intravenous arylsulfatase A in metachromatic leukodystrophy: a phase 1/2 study

Annals of Clinical and Translational Neurology, 2020
Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease caused by deficient activity of arylsulfatase A (ASA), resulting in severe motor and cognitive dysfunction.
C. í Dali, S. Groeschel, M. Moldovan, M. Farah, I. Krägeloh-Mann, M. Wasilewski, Jing Li, N. Barton, C. Krarup   +8 more
semanticscholar   +1 more source

Lysosomal arylsulfatase deficiencies in humans: Chromosome assignments for arylsulfatase A and B [PDF]

Proceedings of the National Academy of Sciences, 1979
Genetics of human lysosomal arylsulfatases A and B (aryl-sulfate sulfohydrolase, EC 3.1.6.1), associated with childhood disease, has been studied with human-rodent somatic cell hybrids. Deficiency of arylsulfatase A (ARS A ) in humans results in a progressive neurodegenerative disease, metachromatic leukodystrophy ...
Thomas B. Shows, Chester DeLuca, Judith A. Brown   +2 more
openaire   +3 more sources

Complete Mapping of a Cystine Knot and Nested Disulfides of Recombinant Human Arylsulfatase A by Multi-Enzyme Digestion and LC-MS Analysis Using CID and ETD

Journal of the American Society for Mass Spectrometry, 2012
Wenqin Ni, Melanie Lin, Paul A. Salinas, Philip J. Savickas, Shiaw‐Lin Wu, Barry L. Karger   +5 more
openalex   +2 more sources

Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. [PDF]

, 2020
The hepatic endoplasmic reticulum (ER)-anchored cytochromes P450 (P450s) are mixed-function oxidases engaged in the biotransformation of physiologically relevant endobiotics as well as of myriad xenobiotics of therapeutic and environmental relevance ...
Correia, Maria Almira, Kim, Sung-Mi, Kwon, Doyoung   +2 more
core   +2 more sources