Results 51 to 60 of about 7,425 (206)
Neurobiology of Disease, 2004 Metachromatic leukodystrophy (MLD) is a lysosomal lipid storage disease caused by arylsulfatase A deficiency. In MLD patients the sphingolipid sulfatide increasingly accumulates leading to progressive demyelination.
K Saravanan +7 more
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JIMD Reports, 2022 Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by a deficiency of the arylsulfatase A (ARSA). ARSA deficiency leads to an accumulation of sulfatides primarily in the nervous system ultimately causing demyelination. With evolving
Lucia Laugwitz +9 more
doaj +1 more source
Advances in Agriculture, Volume 2026, Issue 1, 2026.Coffee (Coffea canephora) takes 2 to 3 years to begin yielding, during which period the young coffee plants do not fully occupy the land. Introduction of fast‐growing food crops during these early stages will help maximize land use, provide early income, improve soil health, reduce weed pressure, and moderate the microclimate.
Sampson Konlan +7 more
wiley +1 more source
Agrosystems, Geosciences &Environment, Volume 8, Issue 4, December 2025.Abstract The use of conventional tillage practices in crop production systems has led to a significant soil loss in many regions of Iran. Conservation tillage practices can help restore the degraded soils. A 2‐year experiment was conducted in an irrigated corn (Zea mays L.) cropping system during the 2014–2016 growing seasons on a silty clay soil with ...
Abdolhossein Parandi +3 more
wiley +1 more source
Microbiological characterization of land set-aside before and after Roundup desiccation
Plant, Soil and Environment, 2011 Luvic chernozem (set-aside from 1996) was evaluated. The first period, before Roundup desiccation (2002-2003), was characterized by black, spontaneous and controlled fallows (mowed with the removal of plant biomass or mulched); the following period (2003-
M. Růžková +4 more
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Colorectal Disease, Volume 27, Issue 12, December 2025.Abstract Aim High‐grade squamous intraepithelial lesions (HSILs) of the anus are at risk of progression to anal squamous cell carcinoma (ASCC). However, most HSILs spontaneously regress, while treatment efficacy is debated and associated with side effects. No clear clinical predictors for anal HSIL regression have been validated to date.
Emeric Boisteau +6 more
wiley +1 more source
Molecules, 2021 The aim of the study is to evaluate oxidant–antioxidant balance as well as lysosomal and anti-protease activities in ovarian cancer since it has been emphasized that the crucial inducing factor of carcinogenesis may be reactive oxygen/nitrogen species or,
Paweł Sutkowy +6 more
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The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression
Aging Cell, Volume 24, Issue 11, November 2025.A multi‐omics analysis was performed to uncover the molecular landscape of human cardiac ageing. We report several insights for the first time: a decrease in proteins composing the structural machinery of the heart; a likely compensatory increase in energetic flux and redox reductive capacity; and an increase in lysosomal activity.
Cassandra Malecki +20 more
wiley +1 more source
Accumulation of lysosulfatide in the brain of arylsulfatase A-deficient mice
Lipids in Health and Disease, 2011 Lysosomal storage diseases are a group of disorders where accumulation of catabolites is manifested in the lysosomes of different cell types. In metachromatic leukodystrophy (Arylsulfatase A [EC.3.1.6.8] deficiency) storage of the glycosphingolipid ...
Månsson Jan-Eric +2 more
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Metachromatic Leukodystrophy: Diagnosis, Modeling, and Treatment Approaches
Frontiers in Medicine, 2020 Metachromatic leukodystrophy is a lysosomal storage disease, which is characterized by damage of the myelin sheath that covers most of nerve fibers of the central and peripheral nervous systems.
Alisa A. Shaimardanova +8 more
doaj +1 more source