Results 41 to 50 of about 263,599 (283)

CASPorter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor

Journal of Inflammation Research, 2022
Chan Zou,1,2 Jordan A Beard,1 Guoping Yang,2– 4 William E Evans,1 Erik J Bonten1,5 1Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN, USA; 2Center for Clinical Pharmacology, The Third Xiangya Hospital, Central ...
Zou C, Beard JA, Yang G, Evans WE, Bonten EJ   +4 more
doaj  

Evidence for interaction of the NLRP3 inflammasome and Bruton’s tyrosine kinase in tumor-associated macrophages: implications for myeloid cell production of interleukin-1beta

OncoImmunology, 2019
An inflammatory microenvironment has been shown to play an important role in the growth and metastasis of tumors. The NLRP3 inflammasome is a multi-protein complex of the innate immune system that is responsible for the production of the potent ...
Brooke Benner, Luke Scarberry, Andrew Stiff, Megan C. Duggan, Logan Good, Gabriella Lapurga, Jonathan P. Butchar, Susheela Tridandapani, William E. Carson   +8 more
doaj   +1 more source

Place of Azerbaijan Power System in Inter-State and Intercontinental Associations, Adjusting Capabilities of Power Stations and Recommendations on Their Usage

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2004
The paper considers the place and role of Azerbaijan Power System in the Euro-Asian Power Association which is to be established, power line capacities of inter-state power lines.
N. А. Yusifov
doaj   +1 more source

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly [PDF]

, 2016
Myeloid cells assemble inflammasomes in response to infection or cell damage; cytosolic sensors activate pro–caspase-1, indirectly for the most part, via the adaptors ASC and NLRC4. This leads to secretion of proinflammatory cytokines and pyroptosis.
Adams, Aida, Alvin Lu, Antonin, Arora, Ashour, Barrios-Rodiles, Broz, Broz, Burg, Cai, Catherine Tang, Chakrabarti, Chen, Conrath, de Alba, Delaloye, Doxsey, Emsley, Fernandes-Alnemri, Ferrao, Florian I. Schmidt, Guimaraes, Hamers-Casterman, Hao Wu, Hauenstein, Helma, Hidde L. Ploegh, Hornung, Hu, Irannejad, Jakobs, Jeff W. Chen, Jianbin Ruan, Kagan, Kirchhofer, Kortmann, Lechtenberg, Lin, Lu, Maass, Man, Masumoto, Masumoto, Meerbrey, Milne, Muyldermans, Paalanen, Pardon, Sahillioglu, Sborgi, Shenoy, Sosa, Taipale, Vanaja, Vance, Wu, Wu, Yang, Young, Zhang   +60 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Stochastic yield catastrophes and robustness in self-assembly

eLife, 2020
A guiding principle in self-assembly is that, for high production yield, nucleation of structures must be significantly slower than their growth. However, details of the mechanism that impedes nucleation are broadly considered irrelevant.
Florian M Gartner, Isabella R Graf, Patrick Wilke, Philipp M Geiger, Erwin Frey   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Quantized topological pumping of solitons in nonlinear photonics and ultracold atomic mixtures

Nature Communications, 2022
Synthetic lattice systems are powerful platforms for studying the influence of intrinsic nonlinearities on topological phenomena. Here the authors elucidate the topological transport of solitons in terms of Wannier functions displacement and they ...
Nader Mostaan, Fabian Grusdt, Nathan Goldman   +2 more
doaj   +1 more source

Cognition in Males and Females with Autism: Similarities and Differences [PDF]

, 2012
The male bias in autism spectrum conditions (ASC) has led to females with ASC being under-researched. This lack of attention to females could hide variability due to sex that may explain some of the heterogeneity within ASC.
Allison, Carrie, Auyeung, B., Bailey, Anthony J., Baron-Cohen, S., Baron-Cohen, Simon, Bolton, Patrick F., Bullmore, E. T., Carrington, Sarah, Catani, Marco, Chakrabarti, B., Craig, Michael C., Daly, E. M., Deoni, Sean C. L., Ecker, Christine, Happé, Francesca, Henty, Julian, Jezzard, Peter, Johnston, Patrick, Jones, Derek Kenton, Lai, Meng C., Lombardo, M. V., Madden, Anya, Mullins, Diane, Murphy, Clodagh M., Murphy, Declan, Pasco, Greg, Ruigrok, Amber N. V., Sadek, Susan A., Spain, Debbie, Stewart, Rose, Suckling, John, Wheelwright, Sally J., Willia, Steven C.   +32 more
core   +4 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source