Results 61 to 70 of about 102,781 (311)

CASPorter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor

Journal of Inflammation Research, 2022
Chan Zou,1,2 Jordan A Beard,1 Guoping Yang,2– 4 William E Evans,1 Erik J Bonten1,5 1Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, TN, USA; 2Center for Clinical Pharmacology, The Third Xiangya Hospital, Central ...
Zou C, Beard JA, Yang G, Evans WE, Bonten EJ   +4 more
doaj  

ASC-particle-induced Peritonitis [PDF]

BIO-PROTOCOL, 2016
In response to pathogen infection and tissue damage, inflammasome sensors such as NLRP3 and AIM2 are activated, which triggers PYRIN domain (PYD)-mediated ASC nucleation, followed by self-perpetuating ASC polymerization, which ultimately culminates in caspase-1 activation, interleukin (IL)-1β and IL-18 processing and release and pyroptosis ...
Lucia de Almeida, Andrea Dorfleutner, Christian Stehlik   +2 more
openaire   +3 more sources

Evidence for interaction of the NLRP3 inflammasome and Bruton’s tyrosine kinase in tumor-associated macrophages: implications for myeloid cell production of interleukin-1beta

OncoImmunology, 2019
An inflammatory microenvironment has been shown to play an important role in the growth and metastasis of tumors. The NLRP3 inflammasome is a multi-protein complex of the innate immune system that is responsible for the production of the potent ...
Brooke Benner, Luke Scarberry, Andrew Stiff, Megan C. Duggan, Logan Good, Gabriella Lapurga, Jonathan P. Butchar, Susheela Tridandapani, William E. Carson   +8 more
doaj   +1 more source

COVID-19 pandemic and the exchange rate movements: evidence from six major COVID-19 hot spots

Future Business Journal, 2022
The study’s primary objective is to unravel the nexus between the COVID-19 crisis and the exchange rate movements in the six major COVID-19 hot spots—Brazil, China, India, Italy, Turkey, and the United Kingdom.
Aamir Jamal, Mudaser Ahad Bhat
doaj   +1 more source

IC100: a novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis

Journal of Neuroinflammation, 2020
The inflammasome adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is involved in immune signaling by bridging the interactions between inflammasome sensors and caspase-1.
H. Desu, Melanie J. Plastini, P. Illiano, H. Bramlett, W. Dietrich, J. Vaccari, R. Brambilla, R. Keane   +7 more
semanticscholar   +1 more source

Manganese Activates NLRP3 Inflammasome Signaling and Propagates Exosomal Release of ASC in Microglial Cells

Science Signaling, 2019
Exosomes containing the adaptor ASC spread NLRP3 inflammasome activation between cells after manganese exposure. Exosomes transfer inflammasome activation Chronic occupational exposure to manganese is associated with the development of Parkinson’s ...
S. Sarkar, Dharmin Rokad, Emir Malovic, Jie Luo, Dilshan S. Harischandra, Huajun Jin, V. Anantharam, Xuemei Huang, M. Lewis, A. Kanthasamy, A. Kanthasamy   +10 more
semanticscholar   +1 more source

The Inflammasome Adaptor Protein ASC in Mild Cognitive Impairment and Alzheimer’s Disease

International Journal of Molecular Sciences, 2020
Mild cognitive impairment (MCI) is characterized by memory loss in the absence of dementia and is considered the translational stage between normal aging and early Alzheimer’s disease (AD). Patients with MCI have a greater risk of advancing to AD.
X. Scott, Marisa E. Stephens, Marie C. Desir, W. Dietrich, R. Keane, J. P. de Rivero Vaccari   +5 more
semanticscholar   +1 more source

ASC 2020 Introduction [PDF]

IEEE Transactions on Applied Superconductivity, 2021
The papers in this special section were presented at the virtual 2020 Applied Superconductivity Conference, ASC 2020.
openaire   +1 more source

The Inflammasome Signaling Proteins ASC and IL-18 as Biomarkers of Psoriasis

Frontiers in Pharmacology, 2020
Inflammasome activation in the innate immune response plays a role in the pathogenesis of psoriasis largely due to the increased levels of pro-inflammatory cytokines.
M. Forouzandeh, Jaren Besen, R. Keane, J. P. de Rivero Vaccari   +3 more
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source