Results 41 to 50 of about 265,081 (302)

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]

, 2018
Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S., Champagne, Claudia, Doiron, Karine, Douglas, Todd, Leiva-Torres, Gabriel André, Mayes, Lindsey, Rodrigue-Gervais, Ian Gaël, Saleh, Maya, Vanié, Paulin, Vidal, Silvia M.   +9 more
core   +4 more sources

Evidence for interaction of the NLRP3 inflammasome and Bruton’s tyrosine kinase in tumor-associated macrophages: implications for myeloid cell production of interleukin-1beta

OncoImmunology, 2019
An inflammatory microenvironment has been shown to play an important role in the growth and metastasis of tumors. The NLRP3 inflammasome is a multi-protein complex of the innate immune system that is responsible for the production of the potent ...
Brooke Benner, Luke Scarberry, Andrew Stiff, Megan C. Duggan, Logan Good, Gabriella Lapurga, Jonathan P. Butchar, Susheela Tridandapani, William E. Carson   +8 more
doaj   +1 more source

Place of Azerbaijan Power System in Inter-State and Intercontinental Associations, Adjusting Capabilities of Power Stations and Recommendations on Their Usage

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2004
The paper considers the place and role of Azerbaijan Power System in the Euro-Asian Power Association which is to be established, power line capacities of inter-state power lines.
N. А. Yusifov
doaj   +1 more source

A Hybrid Approach with Multi-channel I-Vectors and Convolutional Neural Networks for Acoustic Scene Classification

, 2017
In Acoustic Scene Classification (ASC) two major approaches have been followed . While one utilizes engineered features such as mel-frequency-cepstral-coefficients (MFCCs), the other uses learned features that are the outcome of an optimization algorithm.
bisot, brookes, brümmer, dehak, dehak, eghbal-zadeh, eghbal-zadeh, elizalde, garcia-romero, hatch, lehner, lin, mika, salamon, valenti, zeinali   +15 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Stochastic yield catastrophes and robustness in self-assembly

eLife, 2020
A guiding principle in self-assembly is that, for high production yield, nucleation of structures must be significantly slower than their growth. However, details of the mechanism that impedes nucleation are broadly considered irrelevant.
Florian M Gartner, Isabella R Graf, Patrick Wilke, Philipp M Geiger, Erwin Frey   +4 more
doaj   +1 more source

Novel therapies for graft versus host disease with a focus on cell therapies

Frontiers in Immunology, 2023
Graft versus host disease (GVHD) can occur at any period post allogeneic hematopoietic stem cell transplantation as a common clinical complication contributing to significant morbidity and mortality.
Robert Zeiser, Olle Ringden, Behnam Sadeghi, Gil Gonen-Yaacovi, Oscar G. Segurado   +4 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

An Investigation of the Environmental Turbulence Factors and their Sources in the Collaboration - Post-harvest Food Loss Relationship [PDF]

, 2015
Recent studies suggested that collaboration among upstream agricultural supply chain (ASC) partners will impact and possibly reduce postharvest food loss (PHFL) levels; a possible direct relationship between collaboration and PHFL was indicated.
Dani, Samir, Despoudi, Stella, Papaioannou, Grammatoula   +2 more
core