Results 31 to 40 of about 102,781 (311)
Targeting endogenous proteins for degradation through the affinity-directed protein missile system [PDF]
Open Biology, 2017 Targeted proteolysis of endogenous proteins is desirable as a research toolkit and in therapeutics. CRISPR/Cas9-mediated gene knockouts are irreversible and often not feasible for many genes.
Luke J. Fulcher +4 more
doaj +1 more source
AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC
Nature, 2009 The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like receptor members TLR3, TLR7 and TLR8, or by the RNA helicases RIG-I (also known as DDX58) and MDA-5 (IFIH1). Little is known about
V. Hornung +7 more
semanticscholar +1 more source
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation
Journal of Experimental Medicine, 2021 Mechanisms negatively controlling activation of NLRP3 inflammasome remain unclear. Li et al. demonstrate that glutathionylation of ASC represses NLRP3 inflammasome activation, and that GSTO1-promoted deglutathionylation of ASC at ER, under metabolic ...
Shuhang Li +21 more
semanticscholar +1 more source
The FASEB Journal, 2019 Severe acute respiratory syndrome Coronavirus (SARS‐CoV) is capable of inducing a storm of proinflammatory cytokines. In this study, we show that the SARS‐CoV open reading frame 3a (ORF3a) accessory protein activates the NLRP3 inflammasome by promoting ...
Kam-Leung Siu +10 more
semanticscholar +1 more source
bioRxiv, 2021 Inflammasomes sense intrinsic and extrinsic danger signals to trigger inflammatory responses and pyroptotic cell death. Homotypic pyrin domain (PYD) interactions of inflammasome forming Nod-like receptors with the adaptor protein ASC mediate ...
Inga V. Hochheiser +7 more
semanticscholar +1 more source
Odessa Astronomical Publications, 2016 From 2012 on radio telescope BSA FIAN multi beams diagram was started. It capable at July 2014 daily observing by 96 beams in declination -8 .. 42 degrees in the frequency band 109-111.5 MHz.
V. A. Samodurov +6 more
doaj +1 more source
Asc-Seurat: analytical single-cell Seurat-based web application
BMC Bioinformatics, 2021 Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of transcriptomes, arising as a powerful tool for discovering and characterizing cell types and their developmental trajectories.
W. Pereira +8 more
semanticscholar +1 more source
A research tool for measuring non-participation of older people in research on digital health
BMC Public Health, 2019 Background Healthcare services are being increasingly digitalised in European countries. However, in studies evaluating digital health technology, some people are less likely to participate than others, e.g.
Arianna Poli +2 more
doaj +1 more source
Parsing the IL-37-Mediated Suppression of Inflammasome Function
Cells, 2020 Interleukin (IL)-37 is a member of the IL-1 family of cytokines. Although its broad anti-inflammatory properties are well described, the effects of IL-37 on inflammasome function remain poorly understood.
Ina Rudloff +9 more
doaj +1 more source
Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases
Cell Death and Disease, 2021 The ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD)) protein is an scaffold component of different inflammasomes, intracellular multiprotein platforms of the innate immune system that are activated in response ...
Paula M Soriano-Teruel +10 more
semanticscholar +1 more source