Results 11 to 20 of about 102,781 (311)
β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia
Cell Reports, 2020 SUMMARY Alzheimer’s disease is the world’s most common neurodegenerative disorder. It is associated with neuroinflammation involving activation of microglia by β-amyloid (Aβ) deposits.
Hannah Scheiblich +2 more
exaly +2 more sources
Cell Reports, 2021 SUMMARY Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that pTau primes and activates IL-1β.
Shanya Jiang +2 more
exaly +2 more sources
Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination
Cell Reports, 2021 SUMMARY Inflammasomes are crucial for innate immunity against infections and, when deregulated, also contribute to inflammatory diseases. Here, we identify a critical function of the E3 ubiquitin ligase Peli1 in regulating the activation of NLRP3 ...
Chun-Jung Ko +2 more
exaly +2 more sources
Unknown/enigmatic functions of extracellular ASC
Immunology, 2021 Apoptosis‐associated speck‐like protein containing a caspase recruit domain (ASC), encoded by PYCARD gene, is a 22 kDa small molecule, which aggregates into ASC specks during inflammasome activation.
Nancy Starobinas +2 more
exaly +2 more sources
Assembly and regulation of ASC specks
Cellular and Molecular Life Sciences, 2016 The inflammasome adapter ASC links activated inflammasome sensors to the effector molecule pro-caspase-1. Recruitment of pro-caspase-1 to ASC promotes the autocatalytic activation of caspase-1, which leads to the release of pro-inflammatory cytokines, such as IL-1β.
Florian Hoss +2 more
openaire +4 more sources
ASC: Adaptive Skill Coordination for Robotic Mobile Manipulation [PDF]
IEEE Robotics and Automation Letters, 2023 We present Adaptive Skill Coordination (ASC) – an approach for accomplishing long-horizon tasks like mobile pick-and-place (i.e., navigating to an object, picking it, navigating to another location, and placing it). ASC consists of three components – (1)
Naoki Yokoyama +6 more
semanticscholar +1 more source
Adsorption properties of carbon adsorbents based on wood waste [PDF]
E3S Web of Conferences, 2023 This article investigates the adsorption properties of carbon adsorbents obtained from wood waste. The work aimed to study the effect of heat treatment and steam activation on the structure of coal and its ability to adsorb benzene. Electron microscopic,
Paygamov Rahimjon +4 more
doaj +1 more source
Folia Neuropathologica, 2021 More than 50 million people are affected by traumatic brain injury (TBI) each year around the world, and nearly half of the population worldwide will have one or more TBI(s) in their lifetime.
Jing Wang +8 more
doaj +1 more source
Inflammasome activity is controlled by ZBTB16-dependent SUMOylation of ASC
Nature Communications, 2023 Inflammasome activity is important for the immune response and is instrumental in numerous clinical conditions. Here we identify a mechanism that modulates the central Caspase-1 and NLR (Nod-like receptor) adaptor protein ASC (apoptosis-associated speck ...
Danfeng Dong +21 more
semanticscholar +1 more source
Proceedings of the 19th international conference on Architectural support for programming languages and operating systems, 2014 We present an architecture designed to transparently and automatically scale the performance of sequential programs as a function of the hardware resources available. The architecture is predicated on a model of computation that views program execution as a walk through the enormous state space composed of the memory and registers of a single-threaded ...
Waterland, Amos +4 more
openaire +2 more sources