Results 21 to 30 of about 102,781 (311)

Evaluating the reactogenicity of COVID-19 vaccines from network-meta analyses

open access: yesExpert Review of Vaccines, 2023
Background Evidence-based reassurances addressing vaccine-related concerns are crucial to promoting primary vaccination, completion of the primary series, and booster vaccination.
Giorgia Tiozzo   +6 more
doaj   +1 more source

The potential of stem cell therapy in Multiple Sclerosis treatment: a review

open access: yesSURE Journal: (Science Undergraduate Research Experience Journal), 2023
Multiple Sclerosis is an autoimmune and neurodegenerative disease of the central nervous system. There are currently 2.8 million people living with Multiple Sclerosis worldwide, including 9000 people in Ireland, with a prevalence of 193 per 100,000 ...
Sorina Amarculesei   +2 more
doaj   +1 more source

The gray zone squamous lesions: ASC-US / ASC-H

open access: yesCytojournal, 2022
The unequivocal and easily recognizable entities of LSIL and HSIL pose no diagnostic problems for a trained eye. However, when the defining morphologic features are either qualitatively or quantitatively insufficient, it is then that the borderline category of “Atypical Squamous cells” (ASC) may have to be used.
Kattoor, Jayasree, Kamal, Meherbano M.
openaire   +2 more sources

Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases

open access: yesJournal of Neuroinflammation, 2022
Background Dysregulated activation of the inflammasome is involved in various human diseases including acute cerebral ischemia, multiple sclerosis and sepsis.
Chen Chen   +18 more
semanticscholar   +1 more source

Crosstalk Between the NLRP3 Inflammasome/ASC Speck and Amyloid Protein Aggregates Drives Disease Progression in Alzheimer’s and Parkinson’s Disease

open access: yesFrontiers in Molecular Neuroscience, 2022
Two key pathological hallmarks of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), are the accumulation of misfolded protein aggregates and the chronic progressive neuroinflammation that they trigger.
J. Hulse, K. Bhaskar
semanticscholar   +1 more source

Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

open access: yesEMBO Molecular Medicine, 2022
Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines.
D. Bertheloot   +16 more
semanticscholar   +1 more source

Fine Brain Functional Parcellation Based on t-Distribution Stochastic Neighbor Embedding and Automatic Spectral Clustering

open access: yesChinese Journal of Magnetic Resonance, 2021
In this paper, a new method for fine brain functional parcellation based on resting-state functional magnetic resonance imaging (rs-fMRI) data was proposed.
Ying HU, Li-jia WANG, Sheng-dong NIE
doaj   +1 more source

Context Matters—Why We Need to Change From a One Size Fits all Approach to Made-to-Measure Therapies for Individual Patients With Pancreatic Cancer

open access: yesFrontiers in Cell and Developmental Biology, 2021
Pancreatic cancer is one of the deadliest cancers and remains a major unsolved health problem. While pancreatic ductal adenocarcinoma (PDAC) is associated with driver mutations in only four major genes (KRAS, TP53, SMAD4, and CDKN2A), every tumor differs
Sushmitha Sankarasubramanian   +11 more
doaj   +1 more source

The ASC-1 Complex Disassembles Collided Ribosomes

open access: yesMolecules and Cells, 2020
Summary Translating ribosomes that slow excessively incur collisions with trailing ribosomes. Persistent collisions are detected by ZNF598, a ubiquitin ligase that ubiquitinates sites on the ribosomal 40S subunit to initiate pathways of mRNA and protein ...
S. Juszkiewicz   +4 more
semanticscholar   +1 more source

THE DAILY 110 MHZ SURVEY (BSA FIAN) IN THE ON-LINE MODE: DATABASE AND PROCESSING ETHODS

open access: yesOdessa Astronomical Publications, 2014
From 2012 on radio telescope BSA FIAN multi beams diagram was started. It capable at July 2014 daily observing by 96   beams in declination -8  .. 42 degrees in the frequency band 109-111.5 MHz.
V. A. Samodurov   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy