Results 101 to 110 of about 10,002 (242)

Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor

MedComm, Volume 6, Issue 9, September 2025.
Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang, Huiqiang Wang, Shuo Wu, Ge Yang, Haiyan Yan, Lijun Qiao, Xingqiong Li, Mengyuan Wu, Jiandong Jiang, Yuhuan Li   +9 more
wiley   +1 more source

When ASFV Infection Meets the cGAS‐STING Signaling Pathway

Transboundary and Emerging Diseases
The African swine fever virus (ASFV) has the ability to infect both wild boars and domestic pigs, regardless of their breeds or ages, often resulting in a mortality rate of 100%. Host innate immunity is the most important defense weapon against invasion of pathogenic microbial infection.
Songbiao Chen, Ke Shang, Ying Wei, Jian Chen, Zuhua Yu, Lei He, Ke Ding   +6 more
openaire   +2 more sources

Resource‐driven changes in wild boar movement and their consequences for the spread of African Swine Fever in the Russian Far East

Wildlife Biology, Volume 2025, Issue 5, September 2025.
Knowledge of animal movement patterns is invaluable to understanding the spread of diseases among wildlife populations. One example is the recent African swine fever (ASF) outbreak among wild boar Sus scrofa populations across East Asia, where there is a lack of information on movements of this species.
Scott J. Waller, Kevin Morelle, Ivan V. Seryodkin, Alexander N. Rybin, Svetlana V. Soutyrina, Alain Licoppe, Mark Hebblewhite, Dale G. Miquelle   +7 more
wiley   +1 more source

African swine fever: a global view of the current challenge [PDF]

, 2015
African Swine Fever (ASF) is an important contagious haemorrhagic viral disease affecting swine whose notification is mandatory due to its high mortality rates and the great sanitary and socioeconomic impact it has on international trade in animal and ...
Ma Carmen Gallardo, Ana de la Torre Reoyo, Jovita Fernández-Pinero, Irene Iglesias, Ma Jesús Muñoz, Ma Luisa Arias   +5 more
core   +1 more source

ASFV infection induces macrophage necroptosis and releases proinflammatory cytokine by ZBP1-RIPK3-MLKL necrosome activation

Frontiers in Microbiology
African swine fever (ASF) is an infectious disease characterized by hemorrhagic fever, which is highly pathogenic and causes severe mortality in domestic pigs. It is caused by the African swine fever virus (ASFV).
Dajun Zhang, Yu Hao, Xing Yang, Xijuan Shi, Dengshuai Zhao, Lingling Chen, Huanan Liu, Zixiang Zhu, Haixue Zheng   +8 more
doaj   +1 more source

Evaluation in Swine of a Recombinant African Swine Fever Virus Lacking the MGF-360-1L Gene

Viruses, 2020
The African swine fever (ASF) pandemic is currently affecting pigs throughout Eurasia, resulting in significant swine production losses. The causative agent, ASF virus (ASFV), is a large, structurally complex virus with a genome encoding more than 160 ...
Elizabeth Ramirez-Medina, Elizabeth A. Vuono, Ayushi Rai, Sarah Pruitt, Ediane Silva, Lauro Velazquez-Salinas, James Zhu, Douglas P. Gladue, Manuel V. Borca   +8 more
doaj   +1 more source

Identification and utility of innate immune system evasion mechanisms of ASFV

Virus Research, 2013
The interferon (IFN) system is an early innate anti-virus host defense mechanism that takes place shortly after entry of the pathogen and long before the onset of adaptive immunity. Thus, African swine fever virus (ASFV), as an acute and persistent virus in pigs, is predicted to have evolved multiple genes for the manipulation and evasion of interferon.
Sílvia, Correia, Sónia, Ventura, Robert Michael, Parkhouse   +2 more
openaire   +2 more sources

Pig carcass decomposition dynamics: Insights into carcass disposal for emergency animal disease management

Australian Veterinary Journal, Volume 103, Issue 9, Page 542-558, September 2025.
Australia is free from many economically devastating emergency animal diseases (EADs) that threaten livestock production in neighbouring countries. In Australia, an important consideration for EAD control is managing susceptible feral animal populations, especially in remote and inaccessible areas where carcass disposal poses considerable logistical ...
O Schlosberg, BD Cowled, J Torpy, A Höger, RE Thompson, TS Barnes, K Richards, RN Hall, EEC Leslie   +8 more
wiley   +1 more source

The African Swine Fever Isolate ASFV-Kenya-IX-1033 Is Highly Virulent and Stable after Propagation in the Wild Boar Cell Line WSL [PDF]

, 2022
Johanneke D. Hemmink, Hussein M. Abkallo, Sonal Henson, Emmanuel Mulaya Khazalwa, Bernard Oduor, Anna Lacasta, Edward Okoth, Victor Riitho, W. H. Fuchs, Richard P. Bishop, Lucilla Steinaa   +10 more
openalex   +1 more source

Predicted foot and mouth disease virus and African swine fever virus inactivation within carcasses undergoing field decomposition in three Australian climate zones

Australian Veterinary Journal, Volume 103, Issue 9, Page 559-570, September 2025.
Australia's large populations of feral and extensively farmed livestock pose challenges to implementing response plans in the event of an Emergency Animal Disease outbreak. This study aimed to determine if a “Destroy and Let Lie” approach to carcass disposal (leaving carcasses in situ to decompose naturally after field euthanasia) would reliably ...
TS Barnes, E Brayley, T Moore, R Allavena, J Meers, D McNab, R Thompson, J Hunnam, D Worsfold, R Cobbold   +9 more
wiley   +1 more source