Results 91 to 100 of about 7,847 (206)

Neuronal Apoptotic Bodies Facilitate Japanese Encephalitis Virus Infection and Pathogenicity

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Japanese encephalitis (JE) caused by Japanese encephalitis virus (JEV) infection remains one of the major types of viral encephalitis. The mechanisms underlying JEV infection and pathogenesis have not been fully elucidated, resulting in the absence of specific therapies for JE. Neuronal apoptosis is a well‐established outcome of JEV infection;
Chuan Zeng, Xiaowei Nan, Ting Wang, Junyao Xiong, Shuo Zhu, Chengjie Yang, Bibo Zhu, Youhui Si, Shengbo Cao, Jing Ye   +9 more
wiley   +1 more source

Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)

Advanced Science, Volume 13, Issue 37, 3 July 2026.
ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang, Jiahao Ding, Si Chen, Lijie Yan, Shichao Ding, Lavonda Li, Junyi Sun, Haodong Liu, Tongge Li, Ning Liu, Mingji Wei, Xiaoyong Zhu, Xiaobo Zou, Shouqi Yuan, Xingcai Zhang   +14 more
wiley   +1 more source

Comparative Analysis of African Swine Fever Virus Genotypes and Serogroups

Emerging Infectious Diseases, 2015
African swine fever virus (ASFV) causes highly lethal hemorrhagic disease among pigs, and ASFV’s extreme antigenic diversity hinders vaccine development. We show that p72 ASFV phylogenetic analysis does not accurately define ASFV hemadsorption inhibition
Alexander Malogolovkin, Galina Burmakina, Ilya Titov, Alexey Sereda, Andrey Gogin, Elena Baryshnikova, Denis Kolbasov   +6 more
doaj   +1 more source

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, Volume 13, Issue 34, 19 June 2026.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

ASFV-intB318L is attenuated in pigs.

(A-C) Body survival (A), temperatures (B), and clinical score (C) of pigs intramuscularly (IM) inoculated with PBS (n = 3), 102.5 HAD50 ASFV-intB318L (n = 5) or ASFV-WT (n = 5).
Chunying Feng (12428466), Weiye Chen (3234612), Jiangnan Li (658317), Qiongqiong Zhou (92521), Zhaoxia Zhang (3714328), Xiaohong Liu (50816), Liang Hu (202392), Yuntao Guan (368332), Changjiang Weng (8127537), Guangqiang Ye (18369131), Xijun He (663738), Zhengshuang Wu (18369134), Xianfeng Zhang (295346), Dongming Zhao (296447), Li Huang (107408), Hongyang Liu (303058), Zhigao Bu (146375), Hefeng Chen (7834751)   +17 more
core   +1 more source

Standardization of pathological investigations in the framework of experimental ASFV infections

Virus Research, 2013
African swine fever is still one of the major viral diseases of swine for which a commercial vaccine is lacking. For the design and development of such preventive products, researchers involved in African swine fever virus (ASFV) vaccinology need standardized challenge protocols and well characterized clinical, pathological and immunological responses ...
Iván, Galindo-Cardiel, María, Ballester, David, Solanes, Miquel, Nofrarías, Sergio, López-Soria, Jordi M, Argilaguet, Anna, Lacasta, Francesc, Accensi, Fernando, Rodríguez, Joaquim, Segalés   +9 more
openaire   +2 more sources

Engineering a Virus‐Derived X Family DNA Polymerase FvPolX for de novo DNA Synthesis

Advanced Science, Volume 13, Issue 32, 9 June 2026.
In this study, a Faustovirus‐derived polymerase (FvPolX) is engineered based on structural and sequence analysis of PolX enzymes. The optimal mutants demonstrate substantially enhanced catalytic activity toward dNTPs and 3′‐ONH2‐dNTPs compared to the wild‐type enzyme.
Chengjie Zhang, Lei Du, Shengying Li
wiley   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

Generation of recombinant ASFV-intB318L virus.

(A) Schematic representation of the generation of ASFV-intB318L virus. (B) PCR verification of the insertion of the p72-EGFP reporter gene cassette in the genome of ASFV-intB318L virus.
Chunying Feng (12428466), Weiye Chen (3234612), Jiangnan Li (658317), Qiongqiong Zhou (92521), Zhaoxia Zhang (3714328), Xiaohong Liu (50816), Liang Hu (202392), Yuntao Guan (368332), Changjiang Weng (8127537), Guangqiang Ye (18369131), Xijun He (663738), Zhengshuang Wu (18369134), Xianfeng Zhang (295346), Dongming Zhao (296447), Li Huang (107408), Hongyang Liu (303058), Zhigao Bu (146375), Hefeng Chen (7834751)   +17 more
core   +1 more source

Epidemiological analysis of African swine fever in the European Union during 2025

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract During 2025, the number of EU Member States affected by African swine fever (ASF) increased from 13 to 14, following the detection of African swine fever virus (ASFV) in wild boar in Spain. The number of ASF outbreaks in domestic pigs in the EU increased from 333 in 2024 to 585 in 2025, largely driven by Romania, accounting for 81% of ...
European Food Safety Authority (EFSA), Karl Ståhl, Anette Boklund, Tomasz Podgórski, Timothée Vergne, Lina Mur, Roxani Aminalragia‐Giamini, Alessia Rusinà, Eliana Lima   +8 more
wiley   +1 more source