Results 111 to 120 of about 9,741 (217)

Recombinant Vaccine Strain ASFV-G-Δ9GL/ΔUK Produced in the IPKM Cell Line Is Genetically Stable and Efficacious in Inducing Protection in Pigs Challenged with the Virulent African Swine Fever Virus Field Isolate Georgia 2010

Pathogens
We have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G-Δ9GL/ΔUK efficiently induces protection in domestic pigs challenged with the virulent strain Georgia 2010 (ASFV-G).
Elizabeth Ramirez-Medina, Ayushi Rai, Nallely Espinoza, Edward Spinard, Ediane Silva, Leeanna Burton, Jason Clark, Amanda Meyers, Alyssa Valladares, Lauro Velazquez-Salinas, Cyril G. Gay, Douglas P. Gladue, Manuel V. Borca   +12 more
doaj   +1 more source

Protective Efficacy of Live-Attenuated ASFV Vaccine Strains against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam

African swine fever virus (ASFV) continues to spread globally causing severe economic losses to the pig farmers. Vietnam licensed two live attenuated vaccines based on the ASFV strains ASFV-G-ΔI177L and ASFV-G-ΔMGF, to control the ongoing ASF outbreaks.
Nguyen Van Diep, Nguyen Van Duc, Nguyen Thi Ngoc, Dang Xuan Vu, Tran Ngoc Tiep, Viet Dung Nguyen, Thi Tam Than, Dustin Maydaniuk, Kalhari Goonewardene, Aruna Ambagala, Van Phan Le   +10 more
openaire   +1 more source

The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses

mBio
Multigene family (MGF) 360 genes, which are African swine fever virus (ASFV) virulence genes, primarily target key host immune molecules to suppress host interferon (IFN) production and interferon-stimulated gene (ISG) transcription, impairing host ...
Hualin Sun, Jifei Yang, Zhonghui Zhang, Mengli Wu, Zhancheng Tian, Ying Liu, Xiaoqiang Zhang, Jianhao Zhong, Songlin Yang, Yikang Chen, Jianxun Luo, Guiquan Guan, Hong Yin, Qingli Niu   +13 more
doaj   +1 more source

Classical swine fever in wild boar: surveillance strategies under the microscope [PDF]

, 2015
Objective: Classical Swine Fever (CSF) is a highly contagious viral disease, which affects all suid species. CSF infection in wild boar can play an important role in disease introduction to commercial pig holdings.
Conraths, Franz J., Peyre, Marie-Isabelle, Schauer, Birgit, Schulz, Katja, Sonnenburg, Jana, Staubach, Christoph, Vergne, Timothée   +6 more
core  

Diverse immune cell profiles in ASFV-associated lymphopenia

Animal Diseases
AbstractPathogenic African swine fever virus (ASFV) remains a lethal causative agent in the domestic pig industry, which poses a burden on the swine market and causes substantial socioeconomic losses worldwide. Currently, there are no commercially efficacious vaccines or specific treatments available for ASF prevention and control.
Wenjing Xiong, Haowei Chen, Yanru Chen, Ke Wang, Tingting Lian, Weijia Zhang, Qing Yu, Xiaochen Gao, Jie Su, Qigai He, Xiangru Wang, Junping Yu, Min Cui   +12 more
openaire   +2 more sources

Kinetics of Viral Genome Distribution in Swine Peripheral Lymphoid Organs Following Oronasal Infection with Attenuated African swine fever virus strains

Viruses
African swine fever (ASF) continues to spread across the globe, causing a severe impact on the swine industry. Passive surveillance based on testing dead pigs is one of the most effective methods for early detection of ASF incursions.
Kalhari Goonewardene, Carissa Embury-Hyatt, Estella Moffat, Aruna Ambagala   +3 more
doaj   +1 more source

Simultaneous ASFV and Haptoglobin Detection by Duplex qPCR Enables Pre-Viremia Diagnosis of African Swine Fever

Viruses
African swine fever (ASF), caused by African swine fever virus (ASFV), has inflicted severe economic losses on China’s pig industry. Existing ASFV nucleic acid detection methods struggle to identify infected pigs in the pre-viremic stage, especially for ...
Yun Bao, Shimin Gao, Shuang Li, Yijie Liu, Fei Gao, Liwei Li, Wu Tong, Changlong Liu, Yanjun Zhou, Yifeng Jiang   +9 more
doaj   +1 more source

Generation of a new Newcastle Disease vaccine by reverse genetics based on a recently genotype XI virus [PDF]

, 2015
Objective: Newcastle disease (ND) is the major viral infection of poultry inducing high morbidity, mortality, and significant economic impacts on the poultry industry. ND is caused by virulent strains of avian paramyxovirus serotype 1 (aPMV-1) which have
Albina, Emmanuel, Liu, Haijin, Minet, Cécile, Servan de Almeida, Renata   +3 more
core  

RNA interference as antiviral therapy against Peste des Petits Ruminants: proof of concept of in vivo efficiency using a small animal model [PDF]

, 2015
Objective: Morbilliviruses are responsible of important diseases in human beings and animals with economical impact in affected countries. “Peste des petits ruminants” is one of these diseases affecting goats and sheep with high mortality and morbidity ...
Albina, Emmanuel, Holz, Carine, Hällbrink, Mattias, Lancelot, Renaud, Langel, Ulo, Libeau, Geneviève, Minet, Cécile, Servan de Almeida, Renata   +7 more
core  

African swine fever virus I177L induces host inflammatory responses by facilitating the TRAF6-TAK1 axis and NLRP3 inflammasome assembly

Journal of Virology
African swine fever virus (ASFV) is the pathogen of African swine fever (ASF), and its infection causes a lethal disease in pigs, with severe pathological lesions.
Pan-Xue Wu, Wen-Ping Yang, Tao Feng, Jing Zhang, Guo-Qiang Zhu, Xu-Guang Du, Yi Ru, Yao-Feng Zhao, Sen Wu, Dan Li, Hai-Xue Zheng   +10 more
doaj   +1 more source