Results 101 to 110 of about 5,108 (173)

ASFV pE146L-induced ER remodeling is essential for viral replication

Journal of Virology
ABSTRACT African swine fever virus (ASFV) causes a severe hemorrhagic disease, posing a significant threat to the global pig industry. Although the ASFV encodes nearly 200 proteins, the functions of many remain unknown. Here, we identify the inner envelope protein pE146L as essential for ASFV replication.
Yilin Guo, Sai Niu, Xueying Wang, Zixuan Wang, Rui Liang, Yubei Tan, Zhen Fu, Zhelin Su, Juan Xu, Hongjun Chen, Yuejun Shi, Limeng Sun, Guiqing Peng   +12 more
openaire   +2 more sources

A triple protein-based ELISA for differential detection of ASFV antibodies

Frontiers in Veterinary Science
African swine fever (ASF) caused by the ASF virus (ASFV) is a severe and highly contagious viral disease that poses a significant threat to the global pig industry. As no vaccines or effective drugs are available to aid prevention and control, early detection is crucial. The emergence of the low-virulence ASFV strain not expressing CD2v/MGFs (ASFVΔCD2v/
Shuai Zhang, Yuzhu Zuo, Wenyuan Gu, Yunhuan Zhao, Ying Liu, Jinghui Fan, Jinghui Fan   +6 more
openaire   +3 more sources

Kinetics of Viral Genome Distribution in Swine Peripheral Lymphoid Organs Following Oronasal Infection with Attenuated African swine fever virus strains

Viruses
African swine fever (ASF) continues to spread across the globe, causing a severe impact on the swine industry. Passive surveillance based on testing dead pigs is one of the most effective methods for early detection of ASF incursions.
Kalhari Goonewardene, Carissa Embury-Hyatt, Estella Moffat, Aruna Ambagala   +3 more
doaj   +1 more source

The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses

mBio
Multigene family (MGF) 360 genes, which are African swine fever virus (ASFV) virulence genes, primarily target key host immune molecules to suppress host interferon (IFN) production and interferon-stimulated gene (ISG) transcription, impairing host ...
Hualin Sun, Jifei Yang, Zhonghui Zhang, Mengli Wu, Zhancheng Tian, Ying Liu, Xiaoqiang Zhang, Jianhao Zhong, Songlin Yang, Yikang Chen, Jianxun Luo, Guiquan Guan, Hong Yin, Qingli Niu   +13 more
doaj   +1 more source

Towards an Original Anti-ASFV Vaccine: Cellular Immunity Induced by Extracellular Vesicles Engineered with ASFV Antigens

Background/Objectives: African Swine Fever (ASF) represents one of the most serious threats to animal health and global food security. The causative agent of ASF is the African swine fever virus (ASFV), a DNA virus belonging to the Asfarviridae family.
Francesco Manfredi, Flavia Ferrantelli, Chiara Chiozzini, Micaela Donnini, Patrizia Leone, Katherina Pugliese, Monica Cagiola, Cecilia Righi, Stefano Petrini, Monica Giammarioli, Francesco Feliziani, Maurizio Federico   +11 more
openaire   +1 more source

African swine fever virus I177L induces host inflammatory responses by facilitating the TRAF6-TAK1 axis and NLRP3 inflammasome assembly

Journal of Virology
African swine fever virus (ASFV) is the pathogen of African swine fever (ASF), and its infection causes a lethal disease in pigs, with severe pathological lesions.
Pan-Xue Wu, Wen-Ping Yang, Tao Feng, Jing Zhang, Guo-Qiang Zhu, Xu-Guang Du, Yi Ru, Yao-Feng Zhao, Sen Wu, Dan Li, Hai-Xue Zheng   +10 more
doaj   +1 more source

The antibodies against the A137R protein drive antibody-dependent enhancement of African swine fever virus infection in porcine alveolar macrophages

Emerging Microbes and Infections
African swine fever virus (ASFV) is the causative agent of African swine fever (ASF), a highly contagious disease that can kill up to 100% of domestic pigs and wild boars.
Xiaoke Yang, Encheng Sun, Huanjie Zhai, Tao Wang, Shida Wang, Yuxuan Gao, Qinghe Hou, Xiangyu Guan, Shuwen Li, Lian-Feng Li, Hongxia Wu, Yuzi Luo, Su Li, Yuan Sun, Dongming Zhao, Yongfeng Li, Hua-Ji Qiu   +16 more
doaj   +1 more source

Simultaneous ASFV and Haptoglobin Detection by Duplex qPCR Enables Pre-Viremia Diagnosis of African Swine Fever

Viruses
African swine fever (ASF), caused by African swine fever virus (ASFV), has inflicted severe economic losses on China’s pig industry. Existing ASFV nucleic acid detection methods struggle to identify infected pigs in the pre-viremic stage, especially for ...
Yun Bao, Shimin Gao, Shuang Li, Yijie Liu, Fei Gao, Liwei Li, Wu Tong, Changlong Liu, Yanjun Zhou, Yifeng Jiang   +9 more
doaj   +1 more source

From hemorrhage to apoptosis: understanding the devastating impact of ASFV on piglets

Microbiology Spectrum
ABSTRACT African swine fever (ASF) is a devastating swine infectious disease that poses a serious threat to the global swine industry. Since ASF was first reported in China in 2018, this disease has caused significant economic losses in China.
Fanghua Xu, Ning Li, Yue Xue, Zhenru Wang, Zheng Fang, Hui An, Sidang Liu, Changjiang Weng, Li Huang, Gang Wang   +9 more
openaire   +2 more sources

ASFV Proteins Presented at the Surface of T7 Phages Induce Strong Antibody Responses and Immune Cell Proliferation in Sus scrofa

Vaccines
Background/Objectives: African swine fever (ASF) causes massive global swine industry losses with no effective vaccine available. This study constructed T7 phages displaying key ASFV proteins to evaluate their potential as an ASF vaccine by assessing ...
Xinyi Zhang, Yingju Xia, Cheng Wang, Yan Li, Zhifei Li, Lu Xu, Junjie Zhao, Zhen Wang, Xingqi Zou, Xinyv Song, Yuanyuan Zhu, Jinhai Huang, Yebing Liu   +12 more
doaj   +1 more source