Results 1 to 10 of about 2,212,038 (235)

Pathogenicity and virulence of chikungunya virus

Virulence
Chikungunya virus (CHIKV) is a mosquito-transmitted, RNA virus that causes an often-severe musculoskeletal illness characterized by fever, joint pain, and a range of debilitating symptoms.
Wesley Freppel, L. A. Silva, Kenneth A. Stapleford, Lara J. Herrero   +3 more
semanticscholar   +5 more sources

Deletion of CD2-like gene from the genome of African swine fever virus strain Georgia does not attenuate virulence in swine

Scientific Reports, 2020
The CD2-like African swine fever virus (ASFV) gene 8DR, (also known as EP402R) encodes for a structural transmembrane glycoprotein that has been shown to mediate hemadsorption and be involved in host immunomodulation as well as the induction of ...

semanticscholar   +1 more source

Increasing clinical virulence in two decades of the Italian HIV epidemic. [PDF]

PLoS Pathogens, 2009
The recent origin and great evolutionary potential of HIV imply that the virulence of the virus might still be changing, which could greatly affect the future of the pandemic.
Viktor Müller, Franco Maggiolo, Fredy Suter, Nicoletta Ladisa, Andrea De Luca, Andrea Antinori, Laura Sighinolfi, Eugenia Quiros-Roldan, Giampiero Carosi, Carlo Torti   +9 more
doaj   +1 more source

Is HIV short-sighted? Insights from a multistrain nested model [PDF]

, 2013
An important component of pathogen evolution at the population level is evolution within hosts. Unless evolution within hosts is very slow compared to the duration of infection, the composition of pathogen genotypes within a host is likely to change ...
Fraser, Christophe, Lythgoe, Katrina A., Pellis, Lorenzo   +2 more
core   +3 more sources

Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in mice

Veterinary Research, 2017
Highly pathogenic avian influenza (HPAI) H5N8 virus has caused considerable economic losses to poultry industry and poses a great threat to public health.
Xiao Wang, Sujuan Chen, Dandan Wang, Xixin Zha, Siwen Zheng, Tao Qin, Wenjun Ma, Daxin Peng, Xiufan Liu   +8 more
doaj   +1 more source

Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models. [PDF]

, 2018
Zika virus (ZIKV) infection during the large epidemics in the Americas is related to congenital abnormities or fetal demise. To date, there is no vaccine, antiviral drug, or other modality available to prevent or treat Zika virus infection.
Hu, Q, Ke, X, Li, P, Liu, Y, Luo, D, Miao, Y, Sun, J, Tan, Z, Wang, H, Wang, T, Xu, F, Zhang, Y, Zheng, Z   +12 more
core   +1 more source

Pathogenicity and virulence of African swine fever virus

Virulence
African swine fever (ASF) is a devastating disease with a high impact on the pork industry worldwide. ASF virus (ASFV) is a very complex pathogen, the sole member of the family Asfaviridae, which induces a state of immune suppression in the host through ...
Ines Ruedas-Torres, Bui Thi To Nga, F. J. Salguero   +2 more
semanticscholar   +1 more source

Species-Specific Host-Virus Interactions: Implications for Viral Host Range and Virulence.

Trends in Microbiology, 2020
A growing number of studies indicate that host species-specific and virus strain-specific interactions of viral molecules with the host innate immune system play a pivotal role in determining virus host range and virulence.
S. Rothenburg, Greg Brennan
semanticscholar   +1 more source

Attenuated Porcine Reproductive and Respiratory Syndrome Virus Regains Its Fatal Virulence by Serial Passaging in Pigs or Porcine Alveolar Macrophages To Increase Its Adaptation to Target Cells

Microbiology Spectrum, 2022
Porcine reproductive and respiratory syndrome (PRRS) is a globally important disease threatening the pork industry, and modified live-virus (MLV) vaccines are widely used for its prevention.
Jingjing Wang, Mengsi Zhang, Xiaochun Cui, Xiang Gao, Weifeng Sun, Xinna Ge, Yongning Zhang, Xin Guo, Jun Han, Lei Zhou, Hanchun Yang   +10 more
doaj   +1 more source

Roadblocks to translational challenges on viral pathogenesis. [PDF]

, 2013
Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven, Drosten, Christian, Picker, Louis, Subbarao, Kanta, Suzich, Joann   +4 more
core   +1 more source