Results 41 to 50 of about 113,172 (159)

Distinct polymorphisms in a single herpesvirus gene are capable of enhancing virulence and mediating vaccinal resistance.

PLoS Pathogens, 2020
Modified-live herpesvirus vaccines are widely used in humans and animals, but field strains can emerge that have a higher virulence and break vaccinal protection.
Andelé M Conradie, Luca D Bertzbach, Jakob Trimpert, Joseph N Patria, Shiro Murata, Mark S Parcells, Benedikt B Kaufer   +6 more
doaj   +1 more source

Analysis of an Intrinsic Mycovirus Associated With Reduced Virulence of the Human Pathogenic Fungus Aspergillus fumigatus

Frontiers in Microbiology, 2020
Aspergillus fumigatus is an airborne fungal pathogen that causes severe infections with invasive growth in immunocompromised patients. Several mycoviruses have recently been isolated from A.
Azusa Takahashi-Nakaguchi, Erika Shishido, Misa Yahara, Syun-ichi Urayama, Kanae Sakai, Hiroji Chibana, Katsuhiko Kamei, Hiromitsu Moriyama, Tohru Gonoi   +8 more
doaj   +1 more source

Contemporary Avian Influenza A Virus Subtype H1, H6, H7, H10, and H15 Hemagglutinin Genes Encode a Mammalian Virulence Factor Similar to the 1918 Pandemic Virus H1 Hemagglutinin

mBio, 2014
Zoonotic avian influenza virus infections may lead to epidemics or pandemics. The 1918 pandemic influenza virus has an avian influenza virus-like genome, and its H1 hemagglutinin was identified as a key mammalian virulence factor.
Li Qi, Lindsey M. Pujanauski, A. Sally Davis, Louis M. Schwartzman, Daniel S. Chertow, David Baxter, Kelsey Scherler, Kevan L. Hartshorn, Richard D. Slemons, Kathie-Anne Walters, John C. Kash, Jeffery K. Taubenberger   +11 more
doaj   +1 more source

Dengue Virus Evolution and Virulence Models [PDF]

Clinical Infectious Diseases, 2007
Dengue virus transmission has increased dramatically in the past 2 decades, making this virus one of the most important mosquito-borne human pathogens. The emergence of dengue hemorrhagic fever in most tropical countries has made its control a public health priority, but no vaccines or treatments exist.
openaire   +2 more sources

Virulence and pathogenesis of non-virulent and virulent strains of pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus

Journal of General Virology, 1994
Pseudorabies virus (PRV) expressing the envelope glycoprotein E1 (E1) of hog cholera virus (HCV) was used as a model to study the potential risks connected with the use of a live herpesvirus vaccine expressing a foreign gene. The gene encoding E1 was inserted into the glycoprotein X (gX) locus of both a virulent PRV strain and a non-virulent PRV strain
W A, Mulder, J, Priem, K L, Glazenburg, F, Wagenaar, E, Gruys, A L, Gielkens, J M, Pol, T G, Kimman   +7 more
openaire   +2 more sources

Virulence in murine model shows the existence of two distinct populations of Brazilian Vaccinia virus strains. [PDF]

PLoS ONE, 2008
Brazilian Vaccinia virus had been isolated from sentinel mice, rodents and recently from humans, cows and calves during outbreaks on dairy farms in several rural areas in Brazil, leading to high economic and social impact.
Jaqueline Maria Siqueira Ferreira, Betânia Paiva Drumond, Maria Isabel Maldonado Coelho Guedes, Marcelo Antônio Pascoal-Xavier, Camila Megale Almeida-Leite, Rosa Maria Esteves Arantes, Bruno Eduardo Fernandes Mota, Jônatas Santos Abrahão, Pedro Augusto Alves, Fernando Meireles Oliveira, Paulo César Peregrino Ferreira, Cláudio Antônio Bonjardim, Zélia Inês Portela Lobato, Erna Geessien Kroon   +13 more
doaj   +1 more source

MiRNA Targeted NP Genome of Live Attenuated Influenza Vaccines Provide Cross-Protection against a Lethal Influenza Virus Infection

Vaccines, 2020
The miRNA-based strategy has been used to develop live attenuated influenza vaccines. In this study, the nucleoprotein (NP) genome segment of the influenza virus was inserted by different perfect miRNA-192-5p target sites, and the virus was rescued by ...
Feixia Gao, Tianhan Yang, Xueying Liu, Feifei Xiong, Jian Luo, Yinglei Yi, Jiangfeng Fan, Ze Chen, Wen-Song Tan   +8 more
doaj   +1 more source

Molecular determinants of Ebola virus virulence in mice. [PDF]

PLoS Pathogens, 2006
Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains elusive.
Hideki Ebihara, Ayato Takada, Darwyn Kobasa, Steven Jones, Gabriele Neumann, Steven Theriault, Mike Bray, Heinz Feldmann, Yoshihiro Kawaoka   +8 more
doaj   +1 more source

Acetylation at K108 of the NS1 protein is important for the replication and virulence of influenza virus

Veterinary Research, 2020
Non-structural protein 1 (NS1) of influenza virus is a multifunctional protein that plays an important role in virus replication and virulence. In this study, an acetylation modification was identified at the K108 residue of the NS1 protein of H1N1 ...
Jingjiao Ma, Rujuan Wu, Guanlong Xu, Yuqiang Cheng, Zhaofei Wang, Heng’an Wang, Yaxian Yan, Jinxiang Li, Jianhe Sun   +8 more
doaj   +1 more source

Genomic polymorphism of the pandemic A (H1N1) influenza viruses correlates with viral replication, virulence, and pathogenicity in vitro and in vivo. [PDF]

PLoS ONE, 2011
The novel pandemic A (H1N1) virus was first identified in Mexico in April 2009 and quickly spread worldwide. Like all influenzas, the H1N1 strain-specific properties of replication, virulence, and pathogenicity are a result of the particular genomic ...
Lili Xu, Linlin Bao, Jianfang Zhou, Dayan Wang, Wei Deng, Qi Lv, Yila Ma, Fengdi Li, Huihui Sun, Lingjun Zhan, Hua Zhu, Chunmei Ma, Yuelong Shu, Chuan Qin   +13 more
doaj   +1 more source