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The pathogenicity and virulence of Sindbis virus
VirulenceSindbis virus (SINV), a widely distributed alphavirus, is both a foundational model for viral replication studies and an underrecognized human pathogen. Despite its typically mild presentation, SINV can lead to prolonged joint pain and, in rare cases, neurological complications. This review explores SINV's molecular biology and clinical manifestations,
Kevin J. Sokoloski +3 more
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Molecular Plant-Microbe Interactions, 2015 Infections of plants by multiple viruses are common in nature and may result in synergisms in pathologies. Several environmental factors influence plant-virus interactions and act on virulence and host defense responses.
Emmanuel Aguilar +5 more
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Frontiers in Microbiology, 2017 To investigate the exact effects of different origins of Newcastle disease virus (NDV) hemagglutinin-neuraminidase (HN) protein to the biological characteristics of the virus, we systematically studied the correlation between the HN protein and NDV ...
Ji-hui Jin +10 more
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Pathogenicity and virulence of Powassan virus
VirulencePowassan viruses (POWV) are emergent tick-borne Flaviviruses that cause severe encephalitis and long-term neurologic sequelae in patients. POWVs are rapidly spread in the saliva of Ixodes tick species during a 15-minute tick bite. In recent years, there has been an increased incidence of severe POWV disease in the Northeastern United States and ...
Manpreet Kaur +2 more
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Pathogenicity and virulence of chikungunya virus
VirulenceChikungunya virus (CHIKV) is a mosquito-transmitted, RNA virus that causes an often-severe musculoskeletal illness characterized by fever, joint pain, and a range of debilitating symptoms. The virus has re-emerged as a global health threat in recent decades, spreading from its origin in Africa across Asia and the Americas, leading to widespread ...
Wesley Freppel +3 more
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BMC Veterinary Research, 2011 Background Marek's disease virus (MDV) is an economically important oncogenic herpesvirus of poultry. Since the 1960s, increasingly virulent strains have caused continued poultry industry production losses worldwide.
Atkins Katherine E +5 more
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Pathogenesis and virulence of Heartland virus
VirulenceHeartland virus (HRTV), an emerging tick-borne pathogenic bunyavirus, has been a concern since 2012, with an increasing incidence, expanding geographical distribution, and high pathogenicity in the United States. Infection from HRTV results in fever, thrombocytopenia, and leucopenia in humans, and in some cases, symptoms can progress to severe outcomes,
Kuan Feng +6 more
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Virulence of Influenza A Virus for Mouse Lung [PDF]
Virus Genes, 1997 The experimental infection of mouse lung with influenza A virus has proven to be an invaluable model for studying the mechanisms of viral adaptation and virulence. These investigations have identified critical roles for the haemagglutinin (HA) and matrix (M) genes of the virus in determining virulence for mouse lung.
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A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of enterovirus 71 in mice. [PDF]
PLoS ONE, 2011 BACKGROUND: Enterovirus 71 (EV71) has emerged as a neuroinvasive virus responsible for several large outbreaks in the Asia-Pacific region while virulence determinant remains unexplored.
Ming-Te Yeh +6 more
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Dengue Virus Markers of Virulence and Pathogenicity [PDF]
Future Virology, 2009 The increased spread of dengue fever and its more severe form, dengue hemorrhagic fever, have made the study of the mosquito-borne dengue viruses that cause these diseases a public health priority. Little is known about how or why the four different (serotypes 1-4) dengue viruses cause pathology in humans only, and there have been no animal models of ...
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