Results 31 to 40 of about 111,893 (295)

Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction [PDF]

, 2012
Genetic drift of influenza virus genomic sequences occurs through the combined effects of sequence alterations introduced by a low fidelity polymerase and the varying selective pressures experienced as the virus migrates through different host ...
García-Sastre, Adolfo, García-Sastre, A., Hunt, V., Squires, R Burke, Scheuermann, Richard H, Liu, Mengya, Galloway, S.E., Klem, Edward, Squires, R.B., Pickett, Brett E, Hale, B.G., Noronha, J.M., Takimoto, T., Hale, Benjamin G, Takimoto, Toru, Air, G.M., Schmolke, M., Klem, E., Liu, M., Hunt, Victoria, McGee, M., Pickett, B.E., Scheuerman, R.H., Noronha, Jyothi M, McGee, Monnie, Schmolke, Mirco, Air, Gillian M, Galloway, Summer E   +27 more
core   +1 more source

Coronavirus PDZ-binding-motifs and virus virulence

, 2020
Trabajo presentado en el Keystone Symposia on Molecular and Cellular Biology. Positive-Strand RNA Viruses, celebrado en Killarney, Kerry (Irlanda), del 9 al 13 de junio de 2019Coronaviruses (CoV) are pathogens responsible for a wide range of existing and
Solá Gurpegui, Isabel, Borg, J. P., Enjuanes Sánchez, Luis, Zimmermann, P., Honrubia, José M., Perlman, Stanley, Fernandez-Delgado, Raúl, Gutierrez-Alvarez, Francisco J., Castaño-Rodríguez, Carlos, Bailly, E.   +9 more
core   +1 more source

The relationship of within-host multiplication and virulence in a plant-virus system. [PDF]

PLoS ONE, 2007
Virulence does not represent any obvious advantage to parasites. Most models of virulence evolution assume that virulence is an unavoidable consequence of within-host multiplication of parasites, resulting in trade-offs between within-host multiplication
Israel Pagán, Carlos Alonso-Blanco, Fernando García-Arenal   +2 more
doaj   +1 more source

Molecular basis for a lack of correlation between viral fitness and cell killing capacity. [PDF]

PLoS Pathogens, 2007
The relationship between parasite fitness and virulence has been the object of experimental and theoretical studies often with conflicting conclusions. Here, we provide direct experimental evidence that viral fitness and virulence, both measured in the ...
Mónica Herrera, Juan García-Arriaza, Nonia Pariente, Cristina Escarmís, Esteban Domingo   +4 more
doaj   +1 more source

Re-Assembly and Analysis of an Ancient Variola Virus Genome

Viruses, 2017
We report a major improvement to the assembly of published short read sequencing data from an ancient variola virus (VARV) genome by the removal of contig-capping sequencing tags and manual searches for gap-spanning reads. The new assembly, together with
Chad Smithson, Jacob Imbery, Chris Upton
doaj   +1 more source

Rift Valley fever virus 78kDa envelope protein attenuates virus replication in macrophage-derived cell lines and viral virulence in mice.

PLoS Neglected Tropical Diseases, 2021
Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus with a wide host range including ruminants and humans. RVFV outbreaks have had devastating effects on public health and the livestock industry in African countries.
Kaori Terasaki, Birte Kalveram, Kendra N Johnson, Terry Juelich, Jennifer K Smith, Lihong Zhang, Alexander N Freiberg, Shinji Makino   +7 more
doaj   +1 more source

Virulence of H5N1 virus in mice attenuates after in vitro serial passages

Virology Journal, 2011
The virulence of A/Vietnam/1194/2004 (VN1194) in mice attenuated after serial passages in MDCK cells and chicken embryos, because the enriched large-plaque variants of the virus had significantly reduced virulence.
Li Yongqiang, Xia Yukun, Zhan Dawei, Hu Yi, Chang Guohui, Liu Bohua, Li Jing, Yang Yinhui, Zhu Qingyu   +8 more
doaj   +1 more source

Vertical transmission selects for reduced virulence in a plant virus and for increased resistance in the host.

PLoS Pathogens, 2014
For the last three decades, evolutionary biologists have sought to understand which factors modulate the evolution of parasite virulence. Although theory has identified several of these modulators, their effect has seldom been analysed experimentally. We
Israel Pagán, Nuria Montes, Michael G Milgroom, Fernando García-Arenal   +3 more
doaj   +1 more source

Comparison of Aerosol Stability of Different Variants of Ebola Virus and Marburg Virus and Virulence of Aerosolised Ebola Virus in an Immune-Deficient Mouse

Viruses, 2022
During outbreaks of virus diseases, many variants may appear, some of which may be of concern. Stability in an aerosol of several Ebola virus and Marburg virus variants was investigated.
Sophie J. Smither, Lin S. Eastaugh, Mark S. Lever   +2 more
doaj   +1 more source

Monoclonal antibodies to a virulent strain of transmissible gastroenteritis virus: comparison of reactivity with virulent and attenuated virus [PDF]

Archives of Virology, 1988
Twelve hybridomas secreting monoclonal antibodies (MAbs) against Miller virulent strain of transmissible gastroenteritis virus (TGEV) were generated and characterized. In a cell culture immunofluorescence (CCIF) assay, three MAbs directed against peplomer protein (E2) had perinuclear fluorescence and four unclassified MAbs showed cell membrane ...
Welch, Siao-Kun Wan, Saif, Linda J.
openaire   +2 more sources