Is HIV short-sighted? Insights from a multistrain nested model [PDF]
, 2013 An important component of pathogen evolution at the population level is evolution within hosts. Unless evolution within hosts is very slow compared to the duration of infection, the composition of pathogen genotypes within a host is likely to change ...
Lythgoe, KA +7 more
core +1 more source
Re-Assembly and Analysis of an Ancient Variola Virus Genome
Viruses, 2017 We report a major improvement to the assembly of published short read sequencing data from an ancient variola virus (VARV) genome by the removal of contig-capping sequencing tags and manual searches for gap-spanning reads. The new assembly, together with
Chad Smithson, Jacob Imbery, Chris Upton
doaj +1 more source
M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit [PDF]
, 2009 Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Camus-Bouclainville, Christelle +10 more
core +1 more source
A new inhibitor of apoptosis from vaccinia virus and eukaryotes. [PDF]
, 2007 A new apoptosis inhibitor is described from vaccinia virus, camelpox virus, and eukaryotic cells. The inhibitor is a hydrophobic, multiple transmembrane protein that is resident in the Golgi and is named GAAP (Golgi anti-apoptotic protein).
Hollinshead, M +19 more
core +1 more source
The relationship of within-host multiplication and virulence in a plant-virus system. [PDF]
PLoS ONE, 2007 Virulence does not represent any obvious advantage to parasites. Most models of virulence evolution assume that virulence is an unavoidable consequence of within-host multiplication of parasites, resulting in trade-offs between within-host multiplication
Israel Pagán +2 more
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Parasite variation and the evolution of virulence in a Daphnia-microparasite system [PDF]
, 2008 Understanding genetic relationships amongst the life-history traits of parasites is crucial for testing hypotheses on the evolution of virulence. This study therefore examined variation between parasite isolates (the bacterium Pasteuria ramosa) from the ...
Little, T. J., Chadwick, W., Watt, K.
core +1 more source
Molecular basis for a lack of correlation between viral fitness and cell killing capacity. [PDF]
PLoS Pathogens, 2007 The relationship between parasite fitness and virulence has been the object of experimental and theoretical studies often with conflicting conclusions. Here, we provide direct experimental evidence that viral fitness and virulence, both measured in the ...
Mónica Herrera +4 more
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MNF, an ankyrin repeat protein of myxoma virus, is part of a native cellular SCF complex during viral infection [PDF]
, 2010 Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Camus-Bouclainville, Christelle +11 more
core +1 more source
Virulence of H5N1 virus in mice attenuates after
Virology Journal, 2011 The virulence of A/Vietnam/1194/2004 (VN1194) in mice attenuated after serial passages in MDCK cells and chicken embryos, because the enriched large-plaque variants of the virus had significantly reduced virulence.
Li Yongqiang +8 more
doaj +1 more source
PLoS Neglected Tropical Diseases, 2021 Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus with a wide host range including ruminants and humans. RVFV outbreaks have had devastating effects on public health and the livestock industry in African countries.
Kaori Terasaki +7 more
doaj +1 more source