Pathogenicity and virulence of chikungunya virus
VirulenceChikungunya virus (CHIKV) is a mosquito-transmitted, RNA virus that causes an often-severe musculoskeletal illness characterized by fever, joint pain, and a range of debilitating symptoms. The virus has re-emerged as a global health threat in recent decades, spreading from its origin in Africa across Asia and the Americas, leading to widespread ...
Wesley Freppel +3 more
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Dengue Virus Virulence and Transmission Determinants
, 2009 The mechanisms of dengue virus (DENV) pathogenesis are little understood because we have no models of disease; only humans develop symptoms (dengue fever, DF, or dengue hemorrhagic fever, DHF) and research has been limited to studies involving patients.
R. Rico-Hesse
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Deletion of African Swine Fever Virus Histone-like Protein, A104R from the Georgia Isolate Drastically Reduces Virus Virulence in Domestic Pigs. [PDF]
Viruses, 2022 African swine fever virus (ASFV) is the etiological agent of a frequently lethal disease, ASF, affecting domestic and wild swine. Currently, ASF is causing a pandemic affecting pig production in Eurasia.
Ramirez-Medina E +9 more
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Molecular determinants of Ebola virus virulence in mice. [PDF]
PLoS Pathogens, 2006 Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains elusive.
Hideki Ebihara +8 more
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Interaction between SARS-CoV PBM and Cellular PDZ Domains Leading to Virus Virulence. [PDF]
VirusesThe interaction between SARS-CoV PDZ-binding motifs (PBMs) and cellular PDZs is responsible for virus virulence. The PBM sequence present in the 3a and envelope (E) proteins of SARS-CoV can potentially bind to over 400 cellular proteins containing PDZ ...
Honrubia JM +13 more
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Pathogenicity and virulence of hepatitis A virus [PDF]
Virulence, 2021 Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely, in a few of them it may follow a prolonged or relapsed course or even a fulminant form.
Pintó, Rosa +6 more
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SERTA Domain Containing Protein 1 (SERTAD1) Interacts with Classical Swine Fever Virus Structural Glycoprotein E2, Which Is Involved in Virus Virulence in Swine. [PDF]
Viruses, 2020 E2 is the major structural glycoprotein of the classical swine fever virus (CSFV). E2 has been shown to be involved in important virus functions such as replication and virulence in swine.
Vuono EA +9 more
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Marek's Disease Virus Virulence Genes Encode Circular RNAs. [PDF]
J Virol, 2022 Circular RNAs (circRNAs) are a recently rediscovered class of functional noncoding RNAs that are involved in gene regulation and cancer development.
Chasseur AS +9 more
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Differential Effect of the Deletion of African Swine Fever Virus Virulence-Associated Genes in the Induction of Attenuation of the Highly Virulent Georgia Strain. [PDF]
Viruses, 2019 African swine fever virus (ASFV) is the etiological agent of an often lethal disease of domestic pigs, African swine fever (ASF). The ASFV Georgia 2007 isolate (ASFV-G) is responsible for the current epidemic situation in Europe and Asia.
Ramirez-Medina E +9 more
europepmc +2 more sources
Pathogenicity and virulence of Hepatitis B virus [PDF]
Virulence, 2022 Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are an estimated 296 million people in the world that are chronically infected by this virus, and many of them will develop severe liver diseases including hepatitis, cirrhosis and hepatocellular carcinoma (HCC).
Yu-Chen Chuang +2 more
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