The phylogenomics of evolving virus virulence. [PDF]
Nat Rev Genet, 2018 How virulence evolves after a virus jumps to a new host species is central to disease emergence. Our current understanding of virulence evolution is based on insights drawn from two perspectives that have developed largely independently: long-standing ...
Geoghegan JL, Holmes EC.
europepmc +7 more sources
Arabidopsis thaliana Genes Associated with Cucumber mosaic virus Virulence and Their Link to Virus Seed Transmission [PDF]
Microorganisms, 2021 Virulence, the effect of pathogen infection on progeny production, is a major determinant of host and pathogen fitness as it affects host fecundity and pathogen transmission.
Nuria Montes +4 more
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Pathogenicity and virulence of Marburg virus
Virulence, 2022 Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death.
Mehedy Hasan Abir +13 more
semanticscholar +6 more sources
Pathogenesis and virulence of herpes simplex virus [PDF]
Virulence, 2021 Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital herpes, herpes stromal keratitis, meningitis and encephalitis.
Shuyong Zhu, A. Viejo-Borbolla
semanticscholar +6 more sources
Marek's Disease Virus Virulence Genes Encode Circular RNAs. [PDF]
J Virol, 2022 Circular RNAs (circRNAs) were rediscovered in recent years both in physiological and pathological contexts, such as in cancer. Viral circRNAs are encoded by at least two human herpesviruses, the Epstein Barr virus and the Kaposi’s Sarcoma-associated ...
Chasseur AS +9 more
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Deletion of African Swine Fever Virus Histone-like Protein, A104R from the Georgia Isolate Drastically Reduces Virus Virulence in Domestic Pigs. [PDF]
Viruses, 2022 African swine fever virus (ASFV) is the etiological agent of a frequently lethal disease, ASF, affecting domestic and wild swine. Currently, ASF is causing a pandemic affecting pig production in Eurasia.
Ramirez-Medina E +9 more
europepmc +2 more sources
Deletion of the H240R Gene in African Swine Fever Virus Partially Reduces Virus Virulence in Swine [PDF]
Viruses, 2023 African swine fever (ASF) is a highly contagious disease that affects wild and domestic swine. Currently, the disease is present as a pandemic affecting pork production in Eurasia and the Caribbean region.
Elizabeth Ramirez-Medina +7 more
doaj +2 more sources
Molecular Determinants of West Nile Virus Virulence and Pathogenesis in Vertebrate and Invertebrate Hosts. [PDF]
Int J Mol Sci, 2020 West Nile virus (WNV), like the dengue virus (DENV) and yellow fever virus (YFV), are major arboviruses belonging to the Flavivirus genus. WNV is emerging or endemic in many countries around the world, affecting humans and other vertebrates.
Fiacre L +5 more
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Host phylogenetic distance drives trends in virus virulence and transmissibility across the animal-human interface. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2019 Historically, efforts to assess ‘zoonotic risk’ have focused mainly on quantifying the potential for cross-species emergence of viruses from animal hosts.
Guth S, Visher E, Boots M, Brook CE.
europepmc +2 more sources
Differential Effect of the Deletion of African Swine Fever Virus Virulence-Associated Genes in the Induction of Attenuation of the Highly Virulent Georgia Strain. [PDF]
Viruses, 2019 African swine fever virus (ASFV) is the etiological agent of an often lethal disease of domestic pigs, African swine fever (ASF). The ASFV Georgia 2007 isolate (ASFV-G) is responsible for the current epidemic situation in Europe and Asia.
Ramirez-Medina E +9 more
europepmc +2 more sources