The Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus [PDF]
Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at the proteolytic cleavage site of the fusion (F) protein.
Peeters, B.P.H. +7 more
core +1 more source
Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence. [PDF]
H9N2 influenza viruses have been circulating worldwide in multiple avian species and have repeatedly infected humans to cause typical disease. The continued avian-to-human interspecies transmission of H9N2 viruses raises concerns about the possibility of
Jingjing Wang +7 more
doaj +1 more source
Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence [PDF]
Some Newcastle disease virus (NDV) variants isolated from pigeons (pigeon paramyxovirus type 1; PPMV-1) do not show their full virulence potential for domestic chickens but may become virulent upon spread in these animals.
Peeters, B.P.H. +9 more
core +1 more source
Background Baculoviruses are significant biocontrol agents of pests in agriculture; however, ultraviolet light B (UV-B) and high temperature inactivate them in the environment within a short time.
Gozde Busra Eroglu, Zihni Demırbag
doaj +1 more source
Species-Specific Contribution of the Four C-Terminal Amino Acids of Influenza A Virus NS1 Protein to Virulence [PDF]
Large-scale sequence analyses of influenza viruses revealed that nonstructural 1 (NS1) proteins from avian influenza viruses have a conserved C-terminal ESEV amino acid motif, while NS1 proteins from typical human influenza viruses have a C-terminal RSKV
Loupias, Josiane +11 more
core +1 more source
Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species [PDF]
Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts.
García-Sastre, Adolfo +42 more
core +2 more sources
The Evolutionary Pathway to Virulence of an RNA Virus [PDF]
Paralytic polio once afflicted almost half a million children each year. The attenuated oral polio vaccine (OPV) has enabled world-wide vaccination efforts, which resulted in nearly complete control of the disease. However, poliovirus eradication is hampered globally by epidemics of vaccine-derived polio.
Stern, Adi +8 more
openaire +5 more sources
Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]
Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
Rixon, F. +43 more
core +1 more source
Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host [PDF]
Schmallenberg virus (SBV) is an emerging orthobunyavirus of ruminants associated with outbreaks of congenital malformations in aborted and stillborn animals.
Gerald Barry +72 more
core +1 more source
Adaption of seasonal H1N1 influenza virus in mice. [PDF]
The experimental infection of a mouse lung with influenza A virus has proven to be an invaluable model for studying the mechanisms of viral adaptation and virulence.
Lili Xu +12 more
doaj +1 more source

