Results 81 to 90 of about 5,108 (173)

Safeguarding a Flagship Species: Integrated Surveillance of Cross‐Species Pathogen Transmission in Giant Panda Ecosystems

Ecology and Evolution, Volume 16, Issue 3, March 2026.
Emerging infectious diseases increasingly threaten giant pandas and cohabiting species. This review analyzes pathogen transmission risks from domestic animals, wildlife, and vectors and proposes an integrated genomic surveillance framework for early warning and biodiversity conservation.
Xiaoli Sun, Yi Peng, Xiaoye Hao, Rong Dong, Zhilin Wang, Le Wang, Chengdong Wang, Xiangdong Wu, Zheng Chen, Wenbo Zhang, Xiaoli Tang   +10 more
wiley   +1 more source

Deletion of the CD2v Gene from the Genome of ASFV-Kenya-IX-1033 Partially Reduces Virulence and Induces Protection in Pigs

Viruses, 2022
Infection of pigs with the African swine fever virus (ASFV) leads to a devastating hemorrhagic disease with a high mortality of up to 100%. In this study, a CD2v gene deletion was introduced to a genotype IX virus from East Africa, ASFV-Kenya-IX-1033 ...
Johanneke D. Hemmink, Emmanuel M. Khazalwa, Hussein M. Abkallo, Bernard Oduor, Jeremiah Khayumbi, Nicholas Svitek, Sonal P. Henson, Sandra Blome, Günther Keil, Richard P. Bishop, Lucilla Steinaa   +10 more
doaj   +1 more source

Seroprevalence of African Swine Fever Virus and Farm Management Practices in Nepal: A Cross‐Sectional Study

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
A cross‐sectional study on seroprevalence of African swine fever virus was conducted across pig farms in Bagmati Province. Of the 324 samples screened, seven tested positive, with an overall seroprevalence of 2.16% . ABSTRACT Background African swine fever (ASF) is a contagious fatal viral disease of pigs caused by ASF virus (ASFV).
Meera Prajapati, Parikshya Gurung, Aashirbad Pokharel, Kusum Pant, Tulsi Ram Gompo, Ram Prasad Poudyal   +5 more
wiley   +1 more source

Advances in Double‐Stranded DNA Targeting Technologies

Exploration, Volume 6, Issue 1, February 2026.
Double‐stranded DNA (dsDNA) plays a crucial role in genetic information storage and disease management, but its inherent stability limits access to internal bases. To overcome this challenge, various high‐specificity molecular targeting technologies have been developed to destabilize the DNA structure.
Zuhao Shen, Yiqun Liu, Yingjie Hao, Yifan Bo, Xiaochuan Dai, Shihui Wang, Tian Xia, Xin Su, Huiyu Liu   +8 more
wiley   +1 more source

Full-Length ASFV B646L Gene Sequencing by Nanopore Offers a Simple and Rapid Approach for Identifying ASFV Genotypes

Viruses
African swine fever (ASF) is an acute, highly hemorrhagic viral disease in domestic pigs and wild boars. The disease is caused by African swine fever virus, a double stranded DNA virus of the Asfarviridae family. ASF can be classified into 25 different genotypes, based on a 478 bp fragment corresponding to the C-terminal sequence of the B646L gene ...
Vivian O’Donnell, Edward Spinard, Lizhe Xu, Amy Berninger, Roger W. Barrette, Douglas P. Gladue, Bonto Faburay   +6 more
openaire   +3 more sources

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source

Evaluation of Cross-Protection of African Swine Fever Vaccine ASFV-G-ΔI177L Between ASFV Biotypes

Vaccines
Background/Objectives: Vaccine development for the prevention of ASF has been very challenging due to the extensive genetic and largely unknown antigenic diversity. Inactivated vaccines, using different inactivation methods and a variety of adjuvants, have been consistently inefficacious.
Manuel V. Borca, Elizabeth Ramirez-Medina, Christine Mutisya, Rose Ojuok, Josiah Odaba, Mark Dihbol, Anna Lacasta, Douglas P. Gladue   +7 more
openaire   +2 more sources

Comparative Analysis of African Swine Fever Virus Genotypes and Serogroups

Emerging Infectious Diseases, 2015
African swine fever virus (ASFV) causes highly lethal hemorrhagic disease among pigs, and ASFV’s extreme antigenic diversity hinders vaccine development. We show that p72 ASFV phylogenetic analysis does not accurately define ASFV hemadsorption inhibition
Alexander Malogolovkin, Galina Burmakina, Ilya Titov, Alexey Sereda, Andrey Gogin, Elena Baryshnikova, Denis Kolbasov   +6 more
doaj   +1 more source

Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature′s Pragmatism

BioMed Research International, Volume 2026, Issue 1, 2026.
The cross‐reactivity of substrates, modulators with other enzymes significantly reduces/prevents our ability to design such highly specific, that is, “one warhead–one target”, modulators. On the other hand, the potential “impasse” fuels repurposing of already developed drugs.
Monika I. Konaklieva, Balbina J. Plotkin, Nahit Gencer   +2 more
wiley   +1 more source

African Swine Fever Virus (ASFV) Indirect ELISA Test Based on the Use of the Soluble Cytoplasmic Semi- purified Antigen (ASFV CP-Ag)

, 2022
The present chapter describes a simple and economic indirect enzyme immunoassay (ELISA ) for African swine fever virus (ASFV) antibody detection based on the use of the soluble cytoplasmic fraction of ASFV-infected monkey stable cells (MS). The soluble antigen proteins of ASFV-infected cells are separated by sucrose precipitation centrifugation, and ...
Carmina, Gallardo, Nieto, R, Arias, M
openaire   +3 more sources