Results 81 to 90 of about 9,741 (217)

Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature′s Pragmatism

BioMed Research International, Volume 2026, Issue 1, 2026.
The cross‐reactivity of substrates, modulators with other enzymes significantly reduces/prevents our ability to design such highly specific, that is, “one warhead–one target”, modulators. On the other hand, the potential “impasse” fuels repurposing of already developed drugs.
Monika I. Konaklieva, Balbina J. Plotkin, Nahit Gencer   +2 more
wiley   +1 more source

ASFV epitope mapping by high density peptides microarrays

Virus Research
African swine fever (ASF) is an acute, highly contagious and deadly infectious disease. It is a threat to animal health with major potential economic and societal impact. Despite decades of ASF vaccine research, still some gaps in knowledge are hindering the development of a functional vaccine.
Cloé Desmet, Bruna Coelho-Cruz, Dora Mehn, Pascal Colpo, Ana Ruiz-Moreno   +4 more
openaire   +3 more sources

A novel TLR3 inhibitor encoded by African swine fever virus (ASFV) [PDF]

Archives of Virology, 2011
African swine fever virus (ASFV) encodes proteins that manipulate important host antiviral mechanisms. Bioinformatic analysis of the ASFV genome revealed ORF I329L, a gene without any previous functional characterization as a possible inhibitor of TLR signaling.
de Oliveira, V. L., Almeida, S. C. P., Soares, H. R., Crespo, A., Marshall-Clarke, S., Parkhouse, R. M. E.   +5 more
openaire   +2 more sources

Target capture sequencing for the first Nigerian genotype I ASFV genome

Microbial Genomics, 2023
African swine fever (ASF) is a contagious viral disease that affects domestic pigs and wild boars, causing significant economic losses globally. After the first Nigerian outbreak in 1997, there have been frequent reports of ASF in pig-producing regions in the country.
Adeniyi C. Adeola, Pam Dachung Luka, Xiangxiang Jiang, Zheng‐Fei Cai, O. O. Oluwole, Xian Shi, Bukola Oladele, Temilola Olorungbounmi, B. A. Boladuro, Oladipo Omotosho, Victor M. O. Okoro, P.M. Dawuda, Sunday Olaogun, Oscar Sanke, Hai‐Bing Xie, Richard P. Bishop, Jianlin Han, Jianbo Li, Ya‐Ping Zhang, Min‐Sheng Peng   +19 more
openaire   +3 more sources

African swine fever virus transmission cycles in Central Europe: evaluation of wild boar-soft tick contacts through detection of antibodies against Ornithodoros erraticus saliva antigen. [PDF]

, 2016
BACKGROUND African swine fever (ASF) is one of the most complex viral diseases affecting both domestic and wild pigs. It is caused by ASF virus (ASFV), the only DNA virus which can be efficiently transmitted by an arthropod vector, soft ticks of the ...
Beer, Martin, Blome, Sandra, Mur, Lina, Oleaga, Ana, Pietschmann, Jana, Pérez Sánchez, Ricardo, Sánchez-Vizcaíno, José Manuel   +6 more
core   +4 more sources

Evolutionary Origins and Virulence Determinants of ST25 Hypervirulent Klebsiella pneumoniae in Swine: Genomic Insights and Functional Validation

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The global spread of multidrug‐resistant hypervirulent Klebsiella pneumoniae (MDR‐HvKp), among which carbapenem‐resistant strains are of major concern, poses a severe threat to public health due to its high mortality rate and extremely limited treatment options.
Zheng Chen, Yang Liu, Congyang Du, Shengguo Gao, Lufeng Zhai, Stefan Schwarz, Weicheng Liu, Qiong Li, Longyu Li, Runhao Yu, Yuzhe Zhao, Hong Yao, Lei Luo, Xue Liu, Chunyan Xu, Xiang-Dang Du, Zongfu Wu   +16 more
wiley   +1 more source

Full-Length ASFV B646L Gene Sequencing by Nanopore Offers a Simple and Rapid Approach for Identifying ASFV Genotypes

Viruses
African swine fever (ASF) is an acute, highly hemorrhagic viral disease in domestic pigs and wild boars. The disease is caused by African swine fever virus, a double stranded DNA virus of the Asfarviridae family. ASF can be classified into 25 different genotypes, based on a 478 bp fragment corresponding to the C-terminal sequence of the B646L gene ...
Vivian O’Donnell, Edward Spinard, Lizhe Xu, Amy Berninger, Roger W. Barrette, Douglas P. Gladue, Bonto Faburay   +6 more
openaire   +3 more sources

Scientific Opinion on animal health risk mitigation treatments as regards imports of animal casings [PDF]

, 2012
<p>Salting with NaCl for 30 days is a well-established and accepted procedure in the casings industry and it has been the standard animal health risk mitigation treatment prescribed in EU legislation for many years.
EFSA Panel on Animal Health and Welfare
core   +1 more source

Emerging Challenges and Advances in Porcine Circovirus: A Decade in Review

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Over the past decade, porcine circoviruses (PCVs) have continued to pose a significant threat to global swine health, and pivotal discoveries have significantly reshaped our understanding of their biology and control. Extensive genomic surveillance has expanded porcine circovirus 2 (PCV2) genotyping from four to at least eight lineages, with PCV2d now ...
Jiawei Zheng, Guoqing Zhang, Peiheng Li, Linzhu Ren, Nan-hua Chen   +4 more
wiley   +1 more source

Evaluation of Cross-Protection of African Swine Fever Vaccine ASFV-G-ΔI177L Between ASFV Biotypes

Vaccines
Background/Objectives: Vaccine development for the prevention of ASF has been very challenging due to the extensive genetic and largely unknown antigenic diversity. Inactivated vaccines, using different inactivation methods and a variety of adjuvants, have been consistently inefficacious.
Manuel V. Borca, Elizabeth Ramirez-Medina, Christine Mutisya, Rose Ojuok, Josiah Odaba, Mark Dihbol, Anna Lacasta, Douglas P. Gladue   +7 more
openaire   +2 more sources