Results 61 to 70 of about 5,108 (173)

Deletion of the EP296R Gene from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or Virulence in Domestic Pigs

Viruses, 2022
African swine fever virus (ASFV) causes a lethal disease (ASF) in domestic pigs, African swine fever (ASF). ASF is currently producing a pandemic affecting pig production across Eurasia, leading to a shortage of food accessibility.
Elizabeth A. Vuono, Elizabeth Ramirez-Medina, Sarah Pruitt, Ayushi Rai, Nallely Espinoza, Edward Spinard, Alyssa Valladares, Ediane Silva, Lauro Velazquez-Salinas, Manuel V. Borca, Douglas P. Gladue   +10 more
doaj   +1 more source

Investigating the Heat Stability and Inactivation Conditions of Decapod Iridescent Virus 1 (DIV1)

Animal Research and One Health, EarlyView.
Heat treatment effectively inactivates decapod iridescent virus 1 (DIV1) under milder conditions than current WOAH recommendations. DIV1 infectivity was eliminated at 56°C for 30 min, 60°C for 15 min, or 70°C for 1 min, providing optimized heat treatment strategies for aquaculture biosecurity and seafood safety.
Yonghui Feng, Xiaomeng Guo, Jingyi Xing, Liang Qiu, Jie Huang   +4 more
wiley   +1 more source

Infection Characteristics and Transcriptomics of African Swine Fever Virus in Bama Minipigs

Microbiology Spectrum, 2022
Animal experiments on African swine fever virus (ASFV) are vital to the study of ASFV; however, ASFV can only infect pigs, and animal experiments need to be performed in animal biosafety level 3 (ABSL-3) laboratories, meaning that many small ABSL-3 ...
Changjie Lv, Jingyu Yang, Li Zhao, Chao Wu, Chao Kang, Qiang Zhang, Xiaomei Sun, Xi Chen, Zhong Zou, Meilin Jin   +9 more
doaj   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

Host Responses to Live-Attenuated ASFV (HLJ/18–7GD)

Viruses, 2022
African swine fever (ASF) is a highly contagious and fatal disease caused by the African swine fever virus. Recently, the multigene family and CD2v gene-deleted ASF vaccine candidate HLJ/18-7GD was found to be safe and effective in laboratory and clinical trials.
Yuqin Fan, Weiye Chen, Chenggang Jiang, Xianfeng Zhang, Ying Sun, Renqiang Liu, Jingfei Wang, Decheng Yang, Dongming Zhao, Zhigao Bu, Xijun He   +10 more
openaire   +3 more sources

Screening and identification of the dominant antigens of the African swine fever virus

Frontiers in Veterinary Science, 2023
African swine fever is a highly lethal contagious disease of pigs for which there is no vaccine. Its causative agent African swine fever virus (ASFV) is a highly complex enveloped DNA virus encoding more than 150 open reading frames.
Zhaoyang Xu, Zhaoyang Xu, Yifan Hu, Junbo Li, Junbo Li, Ancheng Wang, Xin Meng, Xin Meng, Lingchao Chen, Jianchao Wei, Wu Tong, Ning Kong, Lingxue Yu, Hai Yu, Tongling Shan, Guangzhi Tong, Guihua Wang, Hao Zheng, Hao Zheng   +18 more
doaj   +1 more source

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, Volume 13, Issue 34, 19 June 2026.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Lyophilization of ASFV vaccine candidate ASFV-G-ΔI177L offers long term stability

Scientific Reports
AbstractFor over a century African swine fever (ASF) has been causing outbreaks leading to devastating losses for the swine industry. The current pandemic of ASF has shown no signs of stopping and continues to spread causing outbreaks in additional countries.
Nallely Espinoza, Edward Spinard, Ayushi Rai, Elizabeth Ramirez-Medina, Alyssa Valladares, Amanda Meyers, Manuel V. Borca, Douglas P. Gladue   +7 more
openaire   +3 more sources

Inoculation with ASFV-Katanga-350 Partially Protects Pigs from Death during Subsequent Infection with Heterologous Type ASFV-Stavropol 01/08

Viruses, 2023
African swine fever virus (ASFV) is an extremely genetically and phenotypically heterogeneous pathogen. Previously, we have demonstrated that experimental inoculation of pigs with an attenuated strain, Katanga-350 (genotype I, seroimmunotype I) (ASFV-Katanga-350), can induce protective immunity in 80% of European domestic pigs against the homologous ...
Mikhail E. Vlasov, Irina P. Sindryakova, Dmitry A. Kudrjashov, Sergey Y. Morgunov, Olga L. Kolbasova, Valentina M. Lyska, Sergey P. Zhivoderov, Elena Y. Pivova, Vladimir M. Balyshev, Alexey D. Sereda, Denis V. Kolbasov   +10 more
openaire   +3 more sources

Engineering a Virus‐Derived X Family DNA Polymerase FvPolX for de novo DNA Synthesis

Advanced Science, Volume 13, Issue 32, 9 June 2026.
In this study, a Faustovirus‐derived polymerase (FvPolX) is engineered based on structural and sequence analysis of PolX enzymes. The optimal mutants demonstrate substantially enhanced catalytic activity toward dNTPs and 3′‐ONH2‐dNTPs compared to the wild‐type enzyme.
Chengjie Zhang, Lei Du, Shengying Li
wiley   +1 more source