Results 71 to 80 of about 11,516 (233)

ASFV pD345L protein negatively regulates NF-κB signalling by inhibiting IKK kinase activity

Veterinary Research, 2022
The NF-κB pathway is an essential signalling cascade in the defence against viral infections, including African swine fever virus (ASFV) infection. ASFV encodes more than 151 proteins via its own transcription machinery and possesses a great capacity to ...
Huan Chen, Zhenzhong Wang, Xiaoyu Gao, Jiaxuan Lv, Yong-Xin Hu, Yong-Sam Jung, Shan-Yuan Zhu, Xiao-Dong Wu, Ying-Juan Qian, Jian-Jun Dai   +9 more
semanticscholar   +1 more source

African swine fever virus – persistence in different environmental conditions and the possibility of its indirect transmission

Journal of Veterinary Research, 2019
Since 2007, African swine fever (ASF) has posed a serious threat to the European swine industry. In Poland, the numbers of reported outbreaks in pigs and affected areas grow every year.
Mazur-Panasiuk Natalia, Żmudzki Jacek, Woźniakowski Grzegorz   +2 more
doaj   +1 more source

Transboundary risk of African swine fever (ASF): Detection of ASF virus genotype II in pork products carried by international travelers to Indonesia [PDF]

Veterinary World
Background and Aim: African swine fever (ASF), a devastating viral disease in swine caused by ASF virus (ASFV), has led to substantial economic losses, particularly in Asia since 2018.
Atik Ratnawati, Risza Hartawan, Indrawati Sendow, Muharam Saepulloh, Sumarningsih Sumarningsih, Dyah Ayu Hewajuli, Nuryani Zainuddin, Ni Luh Putu Indi Dharmayanti, I. Wayan Teguh Wibawan, Ni Luh Putu Ika Mayasari   +9 more
doaj   +1 more source

Taking a Promising Vaccine Candidate Further: Efficacy of ASFV-G-ΔMGF after Intramuscular Vaccination of Domestic Pigs and Oral Vaccination of Wild Boar

Pathogens, 2022
African swine fever (ASF) is a pandemic threat to the global pig industry and wild suids. A safe and efficacious vaccine could monumentally assist in disease eradication. In the past years, promising live attenuated vaccine candidates emerged in proof-of-
P. Deutschmann, T. Carrau, J. Sehl-Ewert, J. Forth, E. Viaplana, Jose Carlos Mancera, A. Urniza, M. Beer, S. Blome   +8 more
semanticscholar   +1 more source

Impact of ASFV Detergent Inactivation on Biomarkers in Serum and Saliva Samples

Pathogens, 2022
African swine fever (ASF) is a notifiable viral disease of domestic and wild suids. Despite intensive research efforts, the pathogenesis of the disease is still far from being understood. Analysis of biomarkers in different body fluids may supplement traditional pathogenesis studies.
Lorena Franco-Martínez, Martin Beer, Silvia Martínez-Subiela, Edgar García-Manzanilla, Sandra Blome, Tessa Carrau   +5 more
openaire   +3 more sources

Evaluation of the Deletion of MGF110-5L-6L on Swine Virulence from the Pandemic Strain of African Swine Fever Virus and Use as a DIVA Marker in Vaccine Candidate ASFV-G-ΔI177L

Journal of Virology, 2022
Currently, there are no African swine fever (ASF) commercial vaccines that can be used to prevent or control the spread of ASF. The only effective experimental vaccines against ASF are live-attenuated vaccines.
E. Ramirez-Medina, E. Vuono, Ediane Silva, A. Rai, Alyssa Valladares, S. Pruitt, N. Espinoza, Lauro Velázquez-Salinas, M. Borca, D. Gladue   +9 more
semanticscholar   +1 more source

Noblis ASFV PCR Assays

, 2022
Predicted PCR assays for detection of ASFV, including genotypes I and II deverloped at Nobils, Inc. using the BioLaboro pipeline, which includes BioVelocity, Primer 3, and PSET.
Katharine Jennings (12818321), Shane Mitchell (12804159), Daniel Negrón (11779541), Mitchell Holland (12804170), David Ashford (12818285)   +4 more
core   +1 more source

Computational insights in CD58 binding to ASFV CD2v and in silico optimization of nanobody designs against the interface

Open Veterinary Journal
Background: African swine fever (ASF) continues to hamper pork production worldwide. In addition to vaccines, there is a need to develop curative therapeutics, such as highly-specific antibodies or nanobodies, against immunogenic proteins with important
Albert Neil Gura Dulay, Richelle Mae Evasco Padilla, Nyzar Mabeth Obenio Odchimar, Fredmoore Legaspi Orosco   +3 more
doaj   +1 more source

The MGF300-2R-deleted ASFV mutant (Del2R) induces higher production of inflammatory cytokines than does the wild-type ASFV (ASFV-WT) in PAMs.

, 2023
(A) PAMs were mock infected or infected with Del2R or ASFV-WT (MOI = 5) for 12 and 20 h for RNA-seq analysis. Volcano plot of gene changes in Del2R-infected PAMs compared with the expression in ASFV-WT-infected PAMs.
Shujian Huang (1899610), Yuan Sun (15554), Zhanhao Lu (16819609), Rui Luo (169614), Li Pan (49390), Tao Wang (12008), Jing Zhang (23775), Lian-Feng Li (14680123), Yong-Hui Zheng (50334), Huanjie Zhai (11886013), Hua-Ji Qiu (3967025), Jing Lan (1699462)   +11 more
core   +1 more source

Dynamics of African swine fever virus (ASFV) infection in domestic pigs infected with virulent, moderate virulent and attenuated genotype II ASFV European isolates.

Transboundary and Emerging Diseases, 2021
This study aimed to compare the infection dynamics of three genotype II African swine fever viruses (ASFV) circulating in Europe. Eighteen domestic pigs divided into three groups were infected intramuscularly or by direct contact with two haemadsorbent ...
C. Gallardo, A. Soler, I. Nurmoja, C. Cano-Gómez, S. Cvetkova, M. Frant, G. Woźniakowski, A. Simón, C. Pérez, R. Nieto, M. Arias   +10 more
semanticscholar   +1 more source