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Evaluation of the Safety Profile of the ASFV Vaccine Candidate ASFV-G-ΔI177L
Viruses, 2022 African swine fever (ASF) is the cause of a recent pandemic that is posing a threat to much of the world swine production. The etiological agent, ASF virus (ASFV), infects domestic and wild swine, producing a variety of clinical presentations depending ...
Cyril Gay +2 more
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Structures and Functional Diversities of ASFV Proteins [PDF]
Viruses, 2021 African swine fever virus (ASFV), the causative pathogen of the recent ASF epidemic, is a highly contagious double-stranded DNA virus. Its genome is in the range of 170~193 kbp and encodes 68 structural proteins and over 100 non-structural proteins.
Zhongzhou Chen
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Journal of Virology, 2023
African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and acute hemorrhagic viral disease of domestic pigs, with a high mortality approaching 100%. ASFV has spread rapidly worldwide and caused huge economic losses and ecological consequences.
Zhigao Bu, Weiye Chen, Shijun Zhou
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African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and acute hemorrhagic viral disease of domestic pigs, with a high mortality approaching 100%. ASFV has spread rapidly worldwide and caused huge economic losses and ecological consequences.
Zhigao Bu, Weiye Chen, Shijun Zhou
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Quantification of ASFV DNA and RNA in Ornithodoros Soft Ticks
2022Molecular biology methods are highly sensitive to detect the genome of pathogens and to study their biology. Polymerase chain reaction (PCR) and reverse transcription followed by a polymerase chain reaction (RT-PCR) permit the detection of the presence and the replication of African swine fever virus in soft ticks.
Pereira de Oliveira, Rémi +2 more
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ASFV p30 interacts with CCAR2 and MATR3 to promote ASFV replication
Veterinary MicrobiologyAfrican swine fever (ASF) is a highly contagious and lethal disease caused by the African swine fever virus (ASFV). Currently, effective vaccines are not available for the prevention and control of ASF. ASFV is susceptible to mutations as it has a large genome and encodes numerous proteins. In addition to evading the host immune response, ASFV utilizes
Xuefei, Chu +10 more
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Identification and utility of innate immune system evasion mechanisms of ASFV
Virus Research, 2013 The interferon (IFN) system is an early innate anti-virus host defense mechanism that takes place shortly after entry of the pathogen and long before the onset of adaptive immunity. Thus, African swine fever virus (ASFV), as an acute and persistent virus in pigs, is predicted to have evolved multiple genes for the manipulation and evasion of interferon.
Silvia Correia
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Characterization of ASFV Proteins
1987The analysis of polypeptides made in cells infected with African swine fever virus (ASFV) by high-resolution polyacrylamide gel electrophoresis revealed the synthesis of at least 44 polypeptides ranging in molecular weight from 9.5 K to 243 K. Most of the proteins are synthesized within the first eight hours after infection and can be classified as ...
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2022
The present chapter describes a simple and economic indirect enzyme immunoassay (ELISA ) for African swine fever virus (ASFV) antibody detection based on the use of the soluble cytoplasmic fraction of ASFV-infected monkey stable cells (MS). The soluble antigen proteins of ASFV-infected cells are separated by sucrose precipitation centrifugation, and ...
Gallardo, Carmina, R, Nieto, M, Arias
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The present chapter describes a simple and economic indirect enzyme immunoassay (ELISA ) for African swine fever virus (ASFV) antibody detection based on the use of the soluble cytoplasmic fraction of ASFV-infected monkey stable cells (MS). The soluble antigen proteins of ASFV-infected cells are separated by sucrose precipitation centrifugation, and ...
Gallardo, Carmina, R, Nieto, M, Arias
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Triple-target small molecule for PRRSV and ASFV infections
Bioorganic ChemistryPigs are vital sources of food and biological products. However, viruses such as porcine reproductive and respiratory syndrome virus (PRRSV) and African swine fever virus (ASFV) pose significant threats to the global swine industry, resulting in substantial financial losses.
Youle, Zheng +11 more
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