Results 51 to 60 of about 3,855 (194)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Drug-induced liver injury induced by ashwagandha supplementation: a Systematic review of Сase Reports

, 2023
Ashwagandha (Withania somnifera) is widely used in Indian Ayurvedic medicine. Dietary supplements containing ashwagandha are sold in the US and Europe, and there are several known cases of liver damage from ashwagandha supplements.
Alexey Gennadievich Antonov, Polina Rybakova, Alexander Borisovich Miroshnikov   +2 more
core   +1 more source

The Effect of Chronic Oral Administration of Withania Somnifera Root on Learning and Memory in Diabetic Rats Using Passive Avoidance Test

پزشکی بالینی ابن سینا, 2006
Introduction & Objective: Diabetes mellitus (especially type I) is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals.
Mehrdad Roghani, Tourandokht Baluchnejadmojarad, Mohsen Khalili, Seyyedeh Fatemeh Mahdavi Salimi   +3 more
doaj  

A feasible procedure to detect widespread wrong labeling of Ashwagandha root extracts in dietary supplements

Exploration of Foods and Foodomics
Aim: Ashwagandha is a widely recognized medicinal plant in Ayurveda, a traditional Indian system of medicine. These extracts, which are concentrated forms of the root, contain specified withanolides (WLs) at a 5% median concentration on their packaging ...
Bernhard Thalhamer, Markus Himmelsbach, Benjamin Schatzmann, Christian Klampfl, Wolfgang Buchberger   +4 more
doaj   +1 more source

Ashwagandha Root Extract and Its Potential Modulation of CCN1‐Associated Pathways in Sensitive‐Skin Aging

Journal of Cosmetic Dermatology, Volume 25, Issue 7, July 2026.
ABSTRACT Background Cellular Communication Network Factor 1 (CCN1) has been identified as a key regulator of oxidative stress‐induced skin aging and sensitivity. Ashwagandha root extract (ARE) is a promising candidate for modulating CCN1‐associated pathways. Aims To investigate whether ARE can mitigate sensitive‐skin aging by modulating CCN1 expression
Liying Kang, Yanhong Liu, Yuchen Xin, Lin Geng, Shaochun Cai, Jianfang Luo, Shaojie Gu, Shuangyan Wang, Zhiting Zhang, Yan Huang, Guixuan Zhou, Li Ye, Dongcui Li, Naisheng Jiang   +13 more
wiley   +1 more source

Evaluation of Withaferin A Content in Withania somnifera Using NMR and HPLC: A Comparative Assessment of Traditional and PCSL Extraction Methods

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
A comparative evaluation of traditional aqueous extractions and innovative pressurised cyclic solid–liquid extraction is presented for Withania somnifera leaves. Quantitative NMR, validated by HPLC, reveals a markedly enhanced preservation and recovery of withaferin A using PCSL.
Silvana Pedatella, Maria Chiara Di Meo, Daniele Naviglio, Gionata De Vico, Armando Zarrelli   +4 more
wiley   +1 more source

Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract

Journal of Evidence-Based Complementary & Alternative Medicine, 2017
Chronic stress has been associated with a number of illnesses, including obesity. Ashwagandha is a well-known adaptogen and known for reducing stress and anxiety in humans.
Dnyanraj Choudhary MD, Sauvik Bhattacharyya MPharm, PhD, Kedar Joshi MD   +2 more
doaj   +1 more source

Effect of Broad-Spectrum Hemp Extract on Neurobehavioral Activity on the Immobilization Stress-Induced Model in Sprague Dawley Rats

The Scientific World Journal, 2023
Background. Broad-spectrum hemp extract is expected to be a promising new intervention for managing stress and anxiety. Research has shown that the cannabinoids found in Cannabis sativa, such as cannabidiol (CBD), tetrahydrocannabinol (THC), and ...
Devanand Shanmugasundaram, James Martin Roza   +1 more
doaj   +1 more source

Deciphering Antidiabetic, Anti‐Inflammatory, and Anti‐Cholinergic Bioactivities of Withania somnifera (L) Dunal Root Extract: An In Vitro and In Silico Investigation

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
In this investigation, Withania somnifera root ethanol extract displays anti‐inflammatory and antidiabetic properties. Though compounds including withasomniferolide B and sitoindoside IX have been previously identified as phytoconstituents in the plant, in silico analysis from this study revealed them as new lead compounds that could act as potential ...
Lufuno Mulelu, Jacqueline N. Manjia, Kolawole A. Olofinsan, Londiwe Xulu, Motlalepula G. Matsabisa   +4 more
wiley   +1 more source

Molecular insights to the dose-dependent activities of Ashwagandha extracts

, 2023
Background: Stress is an inevitable component of life. Several herbs are known for their health supporting effects that range from treatment of stress, common cold to cancer.
Zhang, Huayue, Kaul, Ashish, Wang, Jia, Kaul, Sunil C., Wadhwa, Renu, Dhanjal, Jaspreet Kaur   +5 more
core