Results 51 to 60 of about 14,723 (146)

Anticancer L-Asparaginase and Phytoactive Compounds From Plant Against MDR (Methicillindrug resistant) and Fungal Isolates

Dose-Response, 2022
L-asparaginase is used in chemotherapy for acute lymphoblastic leukemia and other cancers. L-asparaginase derived from bacterial source triggers immune responses.
Ambreen Aisha, Saba Zahra, Imtiaz M. Tahir, Asim Hussain, Naheed Bano, Alishbah Roobi, Nadia Afsheen, Yasir Saleem   +7 more
doaj   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Managing toxicities with asparaginase-based therapies in adult ALL: summary of an ESMO Open–Cancer Horizons roundtable discussion

ESMO Open, 2020
With recent prospective clinical trials that used paediatric regimens with multiple doses of pegylated form of asparaginase (PEG asparaginase) in adults reporting significantly improved survival compared with historical data with regimens that used less ...
Kjeld Schmiegelow, Patrick W Burke, Dieter Hoelzer, Jae H Park, Dan Douer   +4 more
doaj   +1 more source

Selumetinib as an Effective Therapy of Histiocytic Sarcoma Evolving From a B‐Cell Acute Lymphoblastic Leukaemia

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Introduction Histiocytic sarcoma (HS) is a rare neoplasm derived from non‐Langerhans histiocytic cells, exceptionally arising from B‐ALL. Methods We present the case of a child with high‐risk B‐ALL with PAX5 P80R mutation. Results Despite initial remission, a chemoresistant paravertebral mass was identified as HS.
Laetitia Largeaud, Charlotte Syrykh, Julie Vial, Alban Canali, Isabelle Luquet, François Vergez, Stéphanie Dufrechou, Naïs Prade, André Baruchel, Bastien Gerby, Marie Nolla, Eric Delabesse, Marlène Pasquet   +12 more
wiley   +1 more source

L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand

Cell Death Discovery
L-asparaginase is an indispensable chemotherapeutic drug for patients with acute lymphoblastic leukemia (aLL), a life-threatening lymphoid neoplasm and the prime cause of cancer death among children.
Jung Kwon Lee, Karl Riabowol, Xidi Wang, Ki-Young Lee   +3 more
doaj   +1 more source

Isolation and Purification of L-Asparaginase from Persian Gulf Streptomyces Isolates and Evaluation of It’s Cloned Gene Expression in Escherichia Coli by Real-Time and SDS-PAGE [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Asparaginase enzymes are effective in treating lymphoblastic leukemia cancer. This enzyme is isolated from bacterial sources and commercially available as an anticancer drug.
Hadiseh Soofer, Kumarss Amini, Seyed Mohammad Masoud Shushtarian   +2 more
doaj  

Phenotype, Management, and Outcomes in Paediatric Acute Pancreatitis: A Real‐Life Cross‐Sectional Study

Acta Paediatrica, Volume 115, Issue 4, Page 951-958, April 2026.
ABSTRACT Aim Limited Canadian data on paediatric acute pancreatitis exist. A meta‐analysis of 48 studies reported equal prevalence of acute pancreatitis among various aetiologies, with rates of severe acute pancreatitis at 13.7% in North America.
Catherine Korman, Doha Elhaoua, Sarah Blain, Thomas Li, Mariam Mohamed, Alessandro David, Colette Deslandres, Ugur Halac, Martha Dirks, Kelly Grzywacz, Michel Lallier, Fernando Alvarez, Prévost Jantchou   +12 more
wiley   +1 more source

Role of L-asparaginase in acute lymphoblastic leukemia: focus on adult patients

Blood and Lymphatic Cancer: Targets and Therapy, 2012
Michael E RyttingDepartment of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: Asparaginase preparations deplete asparagine in acute lymphoblastic leukemia (ALL) blasts.
Rytting ME
doaj  

Hyperleukocytosis and Access to Minimal Residual Disease Testing Impact Outcomes in Children With Newly Diagnosed Acute Myeloid Leukemia in Thailand

Pediatric Blood &Cancer, Volume 73, Issue 3, March 2026.
ABSTRACT Background The survival outcomes among children with acute myeloid leukemia (AML) in low‐ and middle‐income countries are still poor despite adopting modern treatment regimens from developed countries. The study aimed to identify additional potential determinant factors for relapse and death among children with AML in Thailand. Methods In all,
Piya Rujkijyanont, Supak Ukritchon, Angkana Winaichatsak, Pitchayanan Kuwatjanakul, Thirachit Chotsampancharoen, Piti Techavichit, Su‐on Chainansamit, Lalita Sathitsamitphong, Kittima Kanchanakamhaeng, Usanarat Anurathapan, Napat Laoaroon, Chonthida Wangkittikal, Chalinee Monsereenusorn, Watinee Sanpote, Nattaporntira Phalakornkul, Pariwan Sripattanatadasakul, Daranee Isaranimitkul, Pokpong Na Songkhla, Phakatip Sinlapamongkolkul, Jassada Buaboonnam, Samart Pakakasama   +20 more
wiley   +1 more source

Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model.

PLoS ONE, 2016
Osteonecrosis is a common dose-limiting toxicity of glucocorticoids. Data from clinical trials suggest that other medications can increase the risk of glucocorticoid-induced osteonecrosis.
Chengcheng Liu, Laura J Janke, Jitesh D Kawedia, Laura B Ramsey, Xiangjun Cai, Leonard A Mattano, Kelli L Boyd, Amy J Funk, Mary V Relling   +8 more
doaj   +1 more source