Results 151 to 160 of about 99,734 (259)

Targeting distinct amino acid metabolic vulnerabilities in IDH-mutant and IDH-wildtype gliomas. [PDF]

Acta Neuropathol Commun
Ohba S, Hirayama A, Teranishi T, Hitachi K, Yamaguchi H, Murayama K, Natsumeda M, Tateishi K, Tsuchida K, Wakimoto H, Saya H, Pieper R, Hirose Y.   +12 more
europepmc   +1 more source

Plant organelle C‐to‐U RNA editing factors can operate successfully in yeast (Saccharomyces cerevisiae) as an easily amenable eukaryotic system for their functional analysis

The FEBS Journal, EarlyView.
Plant‐type pentatricopeptide repeat proteins capable of C‐to‐U RNA editing perform faithfully when expressed in a new heterologous system, the yeast Saccharomyces cerevisiae. They were tested with constitutive and inducible expression and with a set of different solubility tags. PPR56, PPR65, and PPR78 from P.
Shyam Ramanathan, Annika Hanraths, Jingchan Xie, Mareike Schallenberg‐Rüdinger, Volker Knoop   +4 more
wiley   +1 more source

Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma. [PDF]

Front Vet Sci
Suzuki T, Heishima K, Yamazaki J, Yamazaki M, Kinoshita R, Kim S, Hosoya K, Okamatsu-Ogura Y, Sasaki M, Xu P, Yan Q, Kimura T, Aoshima K.   +12 more
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

The impact of acrylamide regulations on the competitive structure of the grain market. [PDF]

Food Chem X
Nowakowski V.
europepmc   +1 more source

A Comparative Analysis of Maillard‐Derived α‐Dicarbonyl Compounds and Advanced Glycation End Products in Fresh, Wet, Kibble, and Freeze‐Dried Dog Foods

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Thermal processing of pet foods can lead to the formation of harmful Maillard reaction products (MRPs), which may compromise nutritional quality and pose health risks to companion animals. This study compared the levels of MRPs in 41 commercial dog foods, including fresh (n = 15), kibble (n = 13), wet (n = 10), freeze‐dried (n = 2), and cold ...
Tolgahan Kocadağlı, Ciara Clarke, Vural Gökmen   +2 more
wiley   +1 more source

The Glutamine-α-Ketoglutarate Metabolic Axis Controls Vascular Smooth Muscle Cell Function. [PDF]

Cells
Peyton KJ, Liu XM, Durante GL, Durante W.   +3 more
europepmc   +1 more source