CLEC18A is a previously poorly characterized C‐type lectin. We mapped the expression of CLEC18A to the proximal tubule of the kidney and found CLEC18A to interact with sulfated glycosaminoglycans on proteoglycans. Furthermore, we found that CLEC18A plays an important role in hindering the progression of clear cell renal cell carcinomas in humans and in
Gustav Jonsson +10 more
wiley +1 more source
Kinetics effect and inhibition mechanism of Tartary buckwheat extracts on acrylamide in the asparagine-glucose system. [PDF]
Zhao W, Jing Y, Li X, Hu X, Wang L.
europepmc +1 more source
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk +8 more
wiley +1 more source
Biomimetic carbon nanopolymers ANM-NPs act on mannose receptors and complement receptors to promote tumor antigen presentation. [PDF]
Feng Z +11 more
europepmc +1 more source
Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa +4 more
wiley +1 more source
Characterization and Optimization of L-Asparaginase Production by <i>Endophytic Fusarium</i> sp3 Isolated From <i>Malcolmia aegyptiaca</i> of Southeast Algeria: Potential for Acrylamide Mitigation in Food Processing. [PDF]
Lakhdari W +13 more
europepmc +1 more source
Investigating the molecular mechanisms underlying the anti‐CRISPR function of AcrIIA13b protein
Anti‐CRISPR protein AcrIIA13b inhibits CRISPR–Cas9 function by preventing target DNA engagement. The Cas9–sgRNA ribonucleoprotein (RNP) normally recognizes the protospacer adjacent motif (PAM) duplex to initiate DNA cleavage. AcrIIA13b binding to the PAM‐interacting WED–PI domain blocks this recognition, leaving the target DNA intact.
So Yeon Lee, Hyun Ho Park
wiley +1 more source
Investigating operational stability and causes of cofactor release in fold type I amine transaminase. [PDF]
Feng X, Chau W, Master ER.
europepmc +1 more source

