Results 101 to 110 of about 467,415 (311)

Aspartate potentiates tobramycin against multidrug-resistant Edwardsiella tarda through enhancing proton motive force and membrane permeability

mSystems
The antibiotic susceptibility/resistance of bacteria is influenced by their metabolic states. In tobramycin-resistant Edwardsiella tarda (LTB4-RTOB), a dynamic metabolic state is observed, characterized by a general reduction in most metabolites as the ...
Ying-yue Zeng, Hui-yin Lin, Si-chen Yuan, Xuan-xian Peng, Hui Li   +4 more
doaj   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

A nanoparticle-L-aspartate oxidase system for D-aspartate production

, 2017
L-Aspartate oxidase (LASPO) performs the stereospecific oxidative deamination of L-aspartic acid to oxalacetate, ammonia and hydrogen peroxide [1].
Cristina Pirrone, Paola D’Arrigo, Ilaria Armenia, Chiara Allegretti, Giovanni Bernardini, ARMENIA, ILARIA, Riccardo Balzaretti, Rosalba Gornati, Loredano Pollegioni, Mattia Valentino   +9 more
core  

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Biological Plausibility of Using Plasma Amino Acid Profile Determination as a Potential Biomarker for Pediatric Patients with Mild Traumatic Brain Injuries

Neurology International
Background: Amino acid biomarkers have a crucial influence on our understanding of brain injury mechanisms, and their plasma concentrations may indicate neurological damage and recovery patterns.
Adán Pérez-Arredondo, Eduardo Cázares-Ramírez, Luis Tristán-López, Carlos Jiménez-Gutiérrez, Diana L. Pérez-Lozano, Ivette A. Martínez-Hernández, Valentina Vega-Rangel, Hugo F. Narváez-González, Camilo Rios, Marina Martínez-Vargas, Luz Navarro, Liliana Carmona-Aparicio   +11 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Methanol extract of Nigella sativa seed induces changes in the levels of neurotransmitter amino acids in male rat brain regions

Pharmaceutical Biology, 2017
Context: Nigella sativa L. (Ranunculaceae) (NS) has been used for medicinal and culinary purposes. Different parts of the plant are used to treat many disorders.
Tarek El-Naggar, María Emilia Carretero, Carmen Arce, María Pilar Gómez-Serranillos   +3 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Aspartate Is Limiting for Hematopoietic Stem Cell Function in vivo

, 2023
A key function of the electron transport chain is to promote aspartate synthesis, which is required for cancer cell proliferation. However, it is unclear whether aspartate is also limiting in normal stem cells, which divide intermittently.
Qi, Le
core  

Aspartate Metabolism‐Driven Gut Microbiota Dynamics and RIP‐Dependent Mitochondrial Function Counteract Oxidative Stress

Advanced Science
Aspartate (Asp) metabolism‐mediated antioxidant functions have important implications for neonatal growth and intestinal health; however, the antioxidant mechanisms through which Asp regulates the gut microbiota and influences RIP activation remain ...
Shunshun Jin, Jian Wu, Chenyu Wang, Yiwen He, Yulong Tang, Le Huang, Hui Zhou, Di Liu, Ziping Wu, Yanzhong Feng, Heshu Chen, Xinmiao He, Guan Yang, Can Peng, Jiazhang Qiu, Tiejun Li, Yulong Yin, Liuqin He   +17 more
doaj   +1 more source