Results 101 to 110 of about 572,945 (313)

A Randomized Add-on Trial of an N-methyl-d-aspartate Antagonist in Treatment-Resistant Bipolar Depression

Archives of General Psychiatry, 2010
Context Existing therapies for bipolar depression have a considerable lag of onset of action. Pharmacological strategies that produce rapid antidepressant effects—for instance, within a few hours or days—would have an enormous impact on patient care and ...
N. Diazgranados, Lobna A Ibrahim, Nancy E. Brutsché, Andrew R Newberg, Phillip Kronstein, S. Khalifé, W. Kammerer, Z. Quezado, D. Luckenbaugh, G. Salvadore, R. Machado-Vieira, H. Manji, C. Zarate   +12 more
semanticscholar   +1 more source

Photoactivable Surfactant Design for In Situ Stabilization of Hydrogel Bioelectronics

Advanced Materials, EarlyView.
Photoactivable surfactant additive enables in situ stabilization of hydrogel bioelectronics. ABSTRACT Conductive polymer hydrogels offer unique advantages for soft, stretchable biointerfaces by combining tissue‐like mechanics with high ionic conductivity.
Seungyeon Lee, Donggyun Lee, Soo‐Hwan Lee, Yuri Lee, Jooyeun Chong, Gunho Chang, Hyunjun Kim, Aejin Kim, Kyung Su Kim, Jahyun Koo, Hyojin Lee, Jiheong Kang   +11 more
wiley   +1 more source

Hydrogen Bonding of Trialkyl-Substituted Urea in Organic Environment

Molecules
Urea groups appear in many biomolecules and polymers. They have a significant impact on the properties of the materials because of their inherent strength and for their ability to participate in hydrogen bonds.
Zuzana Morávková, Jiří Podešva, Valeriia Shabikova, Sabina Abbrent, Miroslava Dušková-Smrčková   +4 more
doaj   +1 more source

Diversion of aspartate in ASS1-deficient tumors fosters de novo pyrimidine synthesis

Nature, 2015
Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea.
S. Rabinovich, Lital N Adler, K. Yizhak, A. Sarver, Alon Silberman, Shani Agron, Noa Stettner, Qin Sun, A. Brandis, D. Helbling, S. Korman, S. Itzkovitz, D. Dimmock, I. Ulitsky, S. Nagamani, E. Ruppin, A. Erez   +16 more
semanticscholar   +1 more source

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

Aspartate in the Brain: A Review

Neurochemical Research
Abstract l-Aspartate (aspartic acid; C4H7NO4; 2-aminobutanedoic acid) is a non-essential α-amino acid found ubiquitously throughout the body, including in the brain. Aspartate is one of the protein-forming amino acids and the formation of tRNA-aspartate complex is catalysed by aspartyl tRNA synthetase.
Caroline D. Rae, Benjamin D. Rowlands, Vladimir J. Balcar   +2 more
openaire   +2 more sources

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Aspartate potentiates tobramycin against multidrug-resistant Edwardsiella tarda through enhancing proton motive force and membrane permeability

mSystems
The antibiotic susceptibility/resistance of bacteria is influenced by their metabolic states. In tobramycin-resistant Edwardsiella tarda (LTB4-RTOB), a dynamic metabolic state is observed, characterized by a general reduction in most metabolites as the ...
Ying-yue Zeng, Hui-yin Lin, Si-chen Yuan, Xuan-xian Peng, Hui Li   +4 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source