Results 171 to 180 of about 414,727 (380)

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source

Aspartate aminotransferase - risk marker for type-2 diabetes mellitus or red herring? [PDF]

, 2014
Abbasi, Ahn, André, Begg, Doi, Egger, Fraser, Giannini, Goessling, Hanley, Higgins, Jiamjarasrangsi, Kunutsor, Monami, Nakanishi, Nannipieri, Rahmioglu, Robins, Sato, Schneider, Tonelli, Whitfield, Whitfield, Wroblewski, Wroblewski   +24 more
core   +2 more sources

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

New pediatric percentiles of liver enzyme serum levels (alanine aminotransferase, aspartate aminotransferase, γ‐glutamyltransferase): Effects of age, sex, body mass index, and pubertal stage

Hepatology, 2018
Sarah Bussler, M. Vogel, Diana Pietzner, Kristian Harms, Theresa Buzek, Melanie Penke, N. Händel, A. Körner, U. Baumann, W. Kiess, G. Flemming   +10 more
semanticscholar   +1 more source

Studies on the Effect of Some Medicines on the Changes of Aspartate Aminotransferase (2. 6. 1. 1) -Isozyme in the Experimental Myocardial Infarction

, 1967
Susumu Tanimoto
openalex   +2 more sources

Studies of the Selective Permeation of Radioactively Labelled Aspartate Aminotransferase Isozymes into Mitochondria in vitro [PDF]

, 1978
Ersilia Marra, Shawn Doonan, Cecilia Saccone, Ernesto Quagliariello   +3 more
openalex   +1 more source

In Situ Assembly of Fluorogenic RNA for Screening Natural Anti‐Liver Fibrosis Products via Dynamic Visualization of COL1A1 mRNA

Advanced Science, EarlyView.
This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai, Li‐Zeng Zhu, Changfa Shao, Zheng Yin, Qun Liu, Yu Gu, Bin Liu   +6 more
wiley   +1 more source

Effects Alliume Satium and Silybum Marianum Supplements with four Weeks Incremental Training on Some Serum Indicators of Serum Muscle and Liver Damage in Wrestlers

Bihdād, 2020
Bakground: Strenuous exercise, particularly eccentric contractions can lead to exercise-induced muscle damage (EIMD). The aim of this study was to investigate the effect of garlic and silybum marianum supplements with incremental training on some serum ...
Mehdi Sharifian, Naser Behpoor, Hamid Reza Mohajerani, Faramarz Darabi   +3 more
doaj  

Phosphorylation of threonine residue in apo-aspartate aminotransferase during the inhibition with N-(pyridoxyl-5′-phosphate)-L-glutamic acid

, 1969
R. M. Khomutov, Severin Se, Elena N. Khurs, N.N. Gulyaev   +3 more
openalex   +1 more source

NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA

Advanced Science, EarlyView.
Zhan et al. demonstrate the vital role of NAT10‐catalyzed ac4C modification in regulating autophagy‐associated lysosomal acidification. They uncover the clinical and biological significance of ATP6V0E1, an important v‐ATPase assembly subunit, in tumor metastasis, particularly in the malignant progression of ESCC.
Yu‐Juan Zhan, Chun‐Miao Deng, Lin Tang, Shu‐Jun Li, Tao‐Yang Xu, Xian Wei, Xin‐Yi Zhang, Can‐Can Zheng, Li Deng, Cui Shao, Zhong‐Min Ouyang, Alfred King‐Yin Lam, Rong Zhang, Jun Liu, Xing‐Yuan Shi, Zhen‐Yu Pan, Wei Dai, Ming‐Liang He, Simon Law, Xu Li, Xiao‐Bing Chen, Cheng Zhou, Bin Li, Wen‐Wen Xu   +23 more
wiley   +1 more source