Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia. [PDF]
Acta Crystallogr F Struct Biol Commun, 2015 The structures of three aspartate aminotransferases (AATs) from eukaryotic pathogens were solved within the Seattle Structural Genomics Center for Infectious Disease (SSGCID). Both the open and closed conformations of AAT were observed.
Abendroth J +9 more
europepmc +2 more sources
Acylation of aspartate aminotransferase [PDF]
Biochemical Journal, 1967 1. Acetylation of aspartate aminotransferase from pig heart inhibits completely the enzymic activity when the coenzyme is in the amino form (pyridoxamine phosphate) or when the coenzyme has been removed, but not when the coenzyme is in the aldehyde form (pyridoxal phosphate). 2.
C Turano +3 more
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Improved l-Leucine Production in Corynebacterium glutamicum by Optimizing the Aminotransferases
Molecules, 2018 The production of branched-chain amino acids (BCAAs) is still challenging, therefore we rationally engineered Corynebacterium glutamicum FA-1 to increase the l-leucine production by optimizing the aminotransferases.
Li-Yan Feng +2 more
doaj +2 more sources
Crystal structure of L-aspartate aminotransferase from Schizosaccharomyces pombe.
PLoS ONE, 2019 L-aspartate aminotransferase is a pyridoxal 5'-phosphate-dependent transaminase that catalyzes reversible transfer of an α-amino group from aspartate to α-ketoglutarate or from glutamate to oxaloacetate.
Soo Yeon Jeong +2 more
doaj +2 more sources
Structural Insights into a Novel Class of Aspartate Aminotransferase from Corynebacterium glutamicum. [PDF]
PLoS ONE, 2016 Aspartate aminotransferase from Corynebacterium glutamicum (CgAspAT) is a PLP-dependent enzyme that catalyzes the production of L-aspartate and α-ketoglutarate from L-glutamate and oxaloacetate in L-lysine biosynthesis.
Hyeoncheol Francis Son, Kyung-Jin Kim
doaj +2 more sources
Association Between Cadmium Exposure and Liver Function in Adults in the United States: A Cross-sectional Study [PDF]
Journal of Preventive Medicine and Public Health, 2021 Objectives Cadmium is widely used, leading to extensive environmental and occupational exposure. Unlike other organs, for which the harmful and carcinogenic effects of cadmium have been established, the hepatotoxicity of cadmium remains unclear.
Dongui Hong +2 more
doaj +1 more source
Prospective analysis of 44 consecutive liver transplants performed at a university hospital [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To analyze the intraoperative and immediate postoperative biochemical parameters of patients submitted to orthotopic liver transplantation. METHODS: Forty four consecutive orthotopic liver transplants performed from October 2009 to December 2010
Orlando Castro e Silva +7 more
doaj +3 more sources
Journal of Pure and Applied Microbiology, 2023 The use of metallic nanoparticles (NPs) in various industrial and biomedical fields is increasing exponentially. As a result, research examining the potentially toxic impact of these NPs on human health is also increasing. Cytochrome P450 (P450s) enzymes
Hayat A. Al-Btoush
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Association between Serum Liver Enzymes and Cardiovascular Diseases: A Case-control Study among Adults with Cardiovascular Disease [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Cardiovascular Diseases (CVDs) are the leading cause of global morbidity and mortality. However, their prevalence is disproportionately distributed, with the highest rate in low-income countries, moderate in middle-income countries, and the
Naval Kishor Yadav +5 more
doaj +1 more source
Mechanisms of the beneficial effect of sevoflurane in liver ischemia/reperfusion injury [PDF]
Acta Cirúrgica Brasileira, 2015 PURPOSE: To evaluate the underlying mechanisms by which sevoflurane protects the liver against ischemia/reperfusion injury evaluate the mechanism by which sevoflurane exerts this protective effect.
Fernanda Paula Cavalcante +7 more
doaj +2 more sources