Results 11 to 20 of about 14,808 (300)

Improved l-Leucine Production in Corynebacterium glutamicum by Optimizing the Aminotransferases [PDF]

Molecules, 2018
The production of branched-chain amino acids (BCAAs) is still challenging, therefore we rationally engineered Corynebacterium glutamicum FA-1 to increase the l-leucine production by optimizing the aminotransferases.
Li-Yan Feng, Jian-Zhong Xu, Wei-Guo Zhang   +2 more
doaj   +2 more sources

Crystal structure of L-aspartate aminotransferase from Schizosaccharomyces pombe. [PDF]

PLoS ONE, 2019
L-aspartate aminotransferase is a pyridoxal 5'-phosphate-dependent transaminase that catalyzes reversible transfer of an α-amino group from aspartate to α-ketoglutarate or from glutamate to oxaloacetate.
Soo Yeon Jeong, Hyeonseok Jin, Jeong Ho Chang   +2 more
doaj   +2 more sources

Effect of a probiotic and metformin on liver aminotransferases in non-alcoholic steatohepatitis: A double blind randomized clinical trial [PDF]

International Journal of Preventive Medicine, 2013
Background : Non-alcoholic steatohepatitis (NASH) is a clinicopathological entity that is being recognized more frequently in recent years. This study aimed to evaluate the effects of Metformin, with and without a probiotic supplement on liver ...
Ahmad Shavakhi, Mohammad Minakari, Hassan Firouzian, Raheleh Assali, Azita Hekmatdoost, Gordon Ferns   +5 more
doaj   +1 more source

Structural Insights into a Novel Class of Aspartate Aminotransferase from Corynebacterium glutamicum. [PDF]

PLoS ONE, 2016
Aspartate aminotransferase from Corynebacterium glutamicum (CgAspAT) is a PLP-dependent enzyme that catalyzes the production of L-aspartate and α-ketoglutarate from L-glutamate and oxaloacetate in L-lysine biosynthesis.
Hyeoncheol Francis Son, Kyung-Jin Kim
doaj   +3 more sources

Metabolic syndrome is linked to a mild elevation in liver aminotransferases in diabetic patients with undetectable non-alcoholic fatty liver disease by ultrasound [PDF]

Diabetology & Metabolic Syndrome, 2010
Background Despite ongoing findings on the relationship between elevated levels of alanine and aspartate aminotransferases (ALT and AST) and metabolic syndrome (MetS), this association in diabetic patients without a known cause for liver enzymes ...
Esteghamati Alireza, Jamali Arsia, Khalilzadeh Omid, Noshad Sina, Khalili Mohammad, Zandieh Ali, Morteza Afsaneh, Nakhjavani Manouchehr   +7 more
doaj   +2 more sources

Aminotransferases during treatment predict long-term survival in patients with autoimmune hepatitis type 1 : a landmark analysis [PDF]

, 2022
BACKGROUND & AIMS: Biochemical remission, important treatment goal in autoimmune hepatitis (AIH), has been associated with better long-term survival.
van den Berg, Aad, Sermon, Filip, Brouwer, J.T., Kuijvenhoven, J.Ph., van Meyel, J.J.M., Drenth, J.P.H., van der Wouden, E.J., van der Meer, Adriaan, Baak, L.C., de Jonge, H.M., van Gerven, N.M., den Ouden, J.W., van Hoek, Bart, Dutch Autoimmune Hepatitis Study Group, [missing], Bouma, G., Klemt-Kropp, M., Bhalla, A., Guichelaar, M.M.J., Baven-Pronk, Martine, Putter, Hein, Vrolijk, J.M., Verhagen, M.A.M.T., Colle, Isabelle, Verdonk, R.C., Schouten, Jeoffrey, de Boer, Y., Koek, G.H., Van Vlierberghe, Hans, Van Steenkiste, Christophe, Biewenga, Maaike, Beuers, U., van Erpecum, K.J., Verhelst, Xavier   +32 more
core   +4 more sources

Interaction of AMP with cytosolic apo-aspartate aminotransferase [PDF]

, 1983
Interaction of cytosolic apo-aspartate aminotransferase with AMP has been studied under equilibrium conditions: e.g., equilibrium dialysis and spectrophotometric titration. Results show that a 1:1 stoichiometric complex AMP—apo-aspartate aminotransferase
A.M. Garzillo, Garzillo, A.M., Marino, G., Di Donato, A., A. Di Donato, G. Marino, Fiore, R., R. Fiore   +7 more
core   +3 more sources

Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate β-lyases, but turnover leads to inactivation [PDF]

, 2003
The mitochondrial and cytosolic branched-chain aminotransferases (BCATm and BCATc) are homodimers in the fold type IV class of pyridoxal 5′-phosphate-containing enzymes that also contains D-amino acid aminotransferase and 4-amino-4-deoxychorismate lyase (
Cooper, A. J L, Hutson, Susan M., Bruschi, Sam A., Conway, Myra   +3 more
core   +1 more source

Mercury Exposure in Association With Decrease of Liver Function in Adults: A Longitudinal Study [PDF]

Journal of Preventive Medicine and Public Health, 2017
Objectives Although mercury (Hg) exposure is known to be neurotoxic in humans, its effects on liver function have been less often reported. The aim of this study was to investigate whether total Hg exposure in Korean adults was associated with elevated ...
Jonghyuk Choi, Sanghyuk Bae, Hyungryul Lim, Ji-Ae Lim, Yong-Han Lee, Mina Ha, Ho-Jang Kwon   +6 more
doaj   +1 more source

MACRO-ASPARTATE AMINOTRANSFERASE

Hepatology and Gastroenterology, 2021
Measurement of serum enzyme activity is one of the most common laboratory tests. Increased activity may be caused by abnormal enzymes with a high molecular mass, the so-called macroenzymes. Macroenzymes may be seen in healthy subjects, but can also be related to disease. Macro-aspartate aminotransferase (macro-AST) is a macroenzyme that results from an
N. N. Silivontchik, A. I. Lednik, O. P. Levchuk, L. I. Plotnikova   +3 more
openaire   +2 more sources