Results 121 to 130 of about 196,077 (338)

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Antiparasitic Effect of Artemisinin Drug on Alanine Transaminase, Aspartate Transaminase, Cholesterol and Triglyceride in Infected Mice with Leishmania donovani

The Iraqi Journal of Medical Sciences
Background: The pathogenic risk caused by the Leishmania donovani (L. donovani) parasite has long been known, and it has become necessary to find a suitable treatment other than traditional medications and their many side effects, among the best ...
Zahraa A. Ali, Hadeel A. Majeed
doaj   +6 more sources

Protective effect of Emilia sonchifolia (L.) against high protein diet induced oxidative stress in pancreas of Wistar rats

Journal of Pharmacy and Bioallied Sciences, 2012
Objectives: The present study was undertaken to investigate the oxidative damage, the biochemical and histopathological changes in the pancreas of the Wistar rats which was fed high protein diet and the recovery after the oral administration of the n ...
Dominic Sophia, Paramasivam Ragavendran, Chinthamony Arul Raj, Velliyur Kanniappan Gopalakrishnan   +3 more
doaj   +1 more source

Multiscale metabolic modeling of C4 plants: connecting nonlinear genome-scale models to leaf-scale metabolism in developing maize leaves

, 2015
C4 plants, such as maize, concentrate carbon dioxide in a specialized compartment surrounding the veins of their leaves to improve the efficiency of carbon dioxide assimilation.
Bogart, Eli, Myers, Christopher R.
core   +3 more sources

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis

Advanced Science, EarlyView.
Considering the great challenge in Glioblastoma multiforme (GBM) treatment, the authors designed and synthesized a multifunctional nanoplatform that effectively induced ferroptosis by synergetically inhibiting intrinsic intrisinc anti‐ferroptosis proteins, GPX4 & DHODH, and realized excellent in vitro and in vivo anti‐GBM effect.
Guodong Ren, Xuewei Wang, Panpan Li, Hao Wu, Zhifei Bi, Qi Gao, Bolong Ma, Zixuan Tian, Jianfei Liu, Fuqiang Feng, Wen Liu, Lin Li, Chengwu Zhang   +12 more
wiley   +1 more source

Aspartate Transaminase AST2 Involved in Sporulation and Necrotrophic Pathogenesis in the Hemibiotrophs Magnaporthe oryzae and Colletotrichum graminicola. [PDF]

Front Microbiol, 2022
Zhang P, Fang Z, Song Y, Wang S, Bao L, Liu M, Dang Y, Wei Y, Zhang SH.   +8 more
europepmc   +1 more source

Haematological Performances of Jaundice Catfish (Clarias gariepinus, Burch) [PDF]

, 2012
The research was aimed to study hematological performances of jaundice and healthy catfish (Clarias gariepinus, Burch.). Fifty fish (i.e. twenty five of jaundice and twenty five of healthy catfish) were collected and analyzed for their hematological ...
Hastuti, Sri, Subandiyono, Subandiyono
core  

Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders [PDF]

, 2010
Michael P. Whyte, Lydia G Kempa, William H. McAlister, Fan Zhang, Steven Mumm, Deborah Wenkert   +5 more
openalex   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

Novel Vascular‐Adaptive Liquid Metal Microspheres Enable Visualized Arterial Embolization Therapy

Advanced Science, EarlyView.
We present drug‐loaded liquid metal microspheres (X‐MEN) as a novel agent for image‐guided arterial embolization. With inherent radiopacity and superior deformability, X‐MEN enables real‐time monitoring and conforms tightly to irregular vessels. This approach ensures precise, long‐lasting embolization without recanalization, addressing critical ...
Chenyu Shen, Junge Chen, Gang Zhang, Zhusheng Liu, Yichen Wan, Lei Lei, Weiyan Ren, Yanyu Zhao, Bozhang Xia, Zhiqiang Yi, Jinjin Wang, Jingwang Gao, Gen Mu, Xing‐Jie Liang, Zhijun Wang   +14 more
wiley   +1 more source