Results 191 to 200 of about 2,639,770 (286)

Synthesis and Anti-Liver Fibrosis Research of Aspartic Acid Derivatives. [PDF]

Molecules
Lv M, Guo S, Yang H, Wang Y, Li Y, Li Y, Yi H, He H, Li Z.   +8 more
europepmc   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Functional Characterization of FgAsp, a Gene Coding an Aspartic Acid Protease in Fusarium graminearum. [PDF]

J Fungi (Basel)
Li P, Fu Z, Wang M, Yang T, Li Y, Ma D.
europepmc   +1 more source

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys, Marco Giulini, Vlad Cojocaru, Anna Engel, Xiaotong Xu, Jorge Roel‐Touris, Cunliang Geng, Francesco Ambrosetti, Brian Jiménez‐García, Zuzana Jandova, Panagiotis I. Koukos, Charlotte van Noort, João M. C. Teixeira, Siri C. van Keulen, Manon Réau, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +16 more
wiley   +1 more source

Aspartic acid residues in BBE-like enzymes from <i>Morus alba</i> promote a function shift from oxidative cyclization to dehydrogenation. [PDF]

Proc Natl Acad Sci U S A
Guo N, Gu J, Zhou Q, Liu F, Dong H, Ding Q, Wang Q, Wu D, Yang J, Fan J, Gao L, Houk KN, Lei X.   +12 more
europepmc   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

L-Aspartic Acid with Dual Functions: An Eco-Friendly and Affordable Choice to Accelerate High Salinity Brine Utilization. [PDF]

Adv Sci (Weinh)
Mao S, Yu Z, Chen J, Shen Y, Li M, Sun C, Lin X, Yang B, Chen T, Huang Q, Li X, Yan J.   +11 more
europepmc   +1 more source

Theoretical Analysis of Androstenone Adsorption on Chimpanzee and Gorilla Olfactory Receptors (G‐Protein): Statistical Physics Modeling, Molecular Docking Simulation, and Thermodynamic Investigation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT An advanced theory based on statistical physics was applied to microscopically investigate androstenone adsorption and its relationship with olfactory perception in chimpanzees and gorillas. For this purpose, dose–response curves of androstenone on olfactory receptors of chimpanzee OR7D4 and gorilla OR7D4 were analyzed by statistical physics ...
Ismahene Ben Khemis, Olfa Noureddine, Fatma Aouaini, Ghadeer Mohsen Albadrani, Ana Carolina Ferreira Piazzi Fuhr, Nizar Lefi, Salah Knani, GuilhermeLuiz Dotto, Abdelmottaleb Ben Lamine   +8 more
wiley   +1 more source

Determination of Trends Underlying Aspartic Acid Isomerization in Intact Proteins Reveals Unusually Rapid Isomerization of Tau. [PDF]

ACS Chem Neurosci
Shoff TA, Van Orman B, Onwudiwe VC, Genereux JC, Julian RR.   +4 more
europepmc   +1 more source