Results 71 to 80 of about 138,442 (297)

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration

Angewandte Chemie, EarlyView.
The nitrosuccinate lyase CreD catalyzes C–NO2 bond formation using nitrite in water and shows synthetic practicality with high turnover numbers up to 102,000. A combination of protein engineering and computational methods helped to reveal the mechanistic principles that underpin this unique enzymatic activity.
Matteo Aleotti, Hannah Dreisbach, Rémi Corlay, Clara Weber, Tamara Reiter, Wael Elaily, Bastian Daniel, Klaus Zangger, Pedro A. Sánchez‐Murcia, Mélanie Hall   +9 more
wiley   +2 more sources

Effect of insect cuticular compounds on appressorium formation and metabolic activity in Metarhizium anisopliae

Frontiers in Microbiology
The rate of appressoria formation following conidial germination in Metarhizium anisopliae is closely associated with its pathogenicity. This study investigated the effects of insect cuticular compounds on the formation and metabolism in M. anisopliae by
Yang Xu, Canxia Wu, Dongxu Wang, Huaxin Cai, Jingyang Ni, Wenzhe Li, Yinghua Tong   +6 more
doaj   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

The free D-Aspartic acid and D-Glumatic acid content of sheep milk and sheep milk products

, 2014
The role of D-amino acids of foods in the human health is a strongly discussed topic and usually, data came from the investigation of cow milk. We have studied the free D-aspartic acid and free D-glutamic acid content of sheep milk, heat-treated sheep ...
Jávor, András, Fenyvessy, József, Bara-Herczegh, Ottilia, Csanádi, József, Csapó, János   +4 more
core   +2 more sources

Structural and Functional Characterization of Two Poly(aspartic acid) Hydrolases

, 2022
Due to the accumulation of polymers in the environment, biodegradable alternatives should be used in place of commonly used polymers like poly(carboxylates). Poly(carboxylates) are water-soluble polymers (WSPs) that make up a variety of consumer products,
Jansch, Amanda
core  

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Aspartic Acid Residue 51 of SaeR Is Essential for Staphylococcus aureus Virulence

Frontiers in Microbiology, 2018
Staphylococcus aureus is a common Gram-positive bacteria that is a major cause of human morbidity and mortality. The SaeR/S two-component sensory system of S. aureus is important for virulence gene transcription and pathogenesis.
Tyler K. Nygaard, Timothy R. Borgogna, Eli W. Sward, Fermin E. Guerra, Jennifer G. Dankoff, Madison M. Collins, Kyler B. Pallister, Liang Chen, Barry N. Kreiswirth, Jovanka M. Voyich   +9 more
doaj   +1 more source

Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo [PDF]

, 2013
N-methyl-d-aspartate receptor (NMDAR) activation can initiate changes in synaptic strength, evident as long-term potentiation (LTP), and is a key molecular correlate of memory formation.
Kerry L. Spear, Seth C. Hopkins, Hopkins, Seth C., David C. Spanswick, Heffernan, Michele L. R., Campbell, Una C., Ross D. Jeggo, Spear, Kerry L., Varney, Mark A., Michele L. R. Heffernan, Thomas H. Large, Spanswick, David C., Jeggo, Ross D., Mark A. Varney, Large, Thomas H., Una C. Campbell   +15 more
core   +1 more source