Results 31 to 40 of about 2,694,907 (129)

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

ROC plots evaluating the performance of DeepDrug3D against the peptidase dataset.

, 2019
The performance is assessed individually for five groups of enzymes, serine endopeptidases (EC 3.4.21), cysteine endopeptidases (EC 3.4.22), aspartic endopeptidases (EC 3.4.23), metalloendopeptidases (EC 3.4.24), and threonine endopeptidases (EC 3.4.25).
Rajiv Gandhi Govindaraj (204730), Michal Brylinski (119287), Limeng Pu (6293801), Jeffrey Mitchell Lemoine (6293804), Hsiao-Chun Wu (192195)   +4 more
core   +1 more source

Genome‐Wide Association Studies of Micro‐and Macro‐Mineral Concentrations in Cultivated, Wild and Native Pea

Legume Science, Volume 8, Issue 4, December 2026.
ABSTRACT Pea (Pisum sativum) is a nutrient‐rich crop that can provide essential nutrients needed for human and animal health. Improving its mineral concentration through genetic selection can enhance its nutritional value and help combat micronutrient deficiencies. This study aimed to investigate the genetic basis of the accumulation of eight minerals (
Maryam Bagheri, Carla S. Santos, Diego Rubiales, Osman Zakaria Wohor, Marta W. Vasconcelos   +4 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

surfactant-induced crystallisation of DI-aspartic acid [PDF]

, 2001
Crystallisation of dl-aspartic acid beneath monolayers at the air-water interface was studied using seven different monolayer films namely stearic acid, methyl stearate, o-octadceyl carbonyl-l-tyrosine methyl ester hydrochloride, polycaprolactone, poly-1-
Al-Mannai, Seema
core   +3 more sources

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

‐Aspartic Acid

, 1994
L-Aspartic acid by successive N-tosylation, anhydride formation, and reduction was converted into (3S)-3-(tosylamino)butano-4-lactone (4). Electrophilic methylation of 4, subsequent iodo-esterification and nucleophilic methylation, followed by ...
Jefford, Charles, Mc Nulty, James, Charles W. Jefford, James McNulty   +3 more
core   +1 more source

The Synthesis of a Chiral β-Amino Acid Derivative by the Grignard Reaction of an Aspartic Acid Equivalent

, 2010
A novel synthetic route to chiral β-amino acid derivative has been developed by a Grignard reaction of 2,4,5-trifluo-rophenyl magnesium bromide with the Weinreb amide derivative of L-aspartic acid. The aspartic equivalent was synthesised from L-aspartic
Xiaohu Tao, Xianhua Pan, Xiaojiong Xu, Libo Ruan, Feng Liu, Xiaoke Wang, Xijiang Peng, Wenhua Ou, Jiaomei Wan, Wansheng Yu, Yiming Li, Jun Mao   +11 more
core   +1 more source

Coat Color‐Associated Transcriptomic Differences of Black and White Hortobágyi Racka Sheep Using the RNA‐Seq Technique

Ecology and Evolution, Volume 16, Issue 10, October 2026.
We compared skin transcriptomes of black‐ and white‐coated Hortobágyi Racka sheep using RNA‐seq to identify coat color‐associated molecular differences. Black‐coated sheep showed coordinated upregulation of melanogenesis and melanosome‐related genes together with pathways linked to redox balance, mitochondrial metabolism, and thermogenesis.
Putri Kusuma Astuti, Zoltán Bagi, Lilla Bodrogi, Szilvia Kusza   +3 more
wiley   +1 more source

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, Volume 38, Issue 52, 16 September 2026.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source