Aspartoacylase suppresses prostate cancer progression by blocking LYN activation [PDF]
Military Medical Research, 2023 Background Globally, despite prostate cancer (PCa) representing second most prevalent malignancy in male, the precise molecular mechanisms implicated in its pathogenesis remain unclear.
Hong Weng +13 more
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Aspartoacylase promotes the process of tumour development and is associated with immune infiltrates in gastric cancer [PDF]
BMC Cancer, 2023 Background Aspartoacylase (ASPA) is a gene that plays an important role in the metabolic reprogramming of cancer. However, the clinical relevance of ASPA in gastric cancer (GC) has not been demonstrated.
Yalin Han +10 more
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Dual-function AAV gene therapy reverses late-stage Canavan disease pathology in mice [PDF]
Frontiers in Molecular Neuroscience, 2022 The leukodystrophy Canavan disease is a fatal white matter disorder caused by loss-of-function mutations of the aspartoacylase-encoding ASPA gene. There are no effective treatments available and experimental gene therapy trials have failed to provide ...
Dominik Fröhlich +8 more
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Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy [PDF]
Annals of Clinical and Translational NeurologyCanavan disease is a leukodystrophy caused by ASPA mutations that diminish oligodendroglial aspartoacylase activity, and is characterized by markedly elevated brain concentrations of the aspartoacylase substrate N‐acetyl‐l‐aspartate (NAA) and by ...
Vanessa L. Hull +8 more
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Increasing Aspartoacylase in the Central Amygdala: The Common Mechanism of Gastroprotective Effects of Monoamine-Based Antidepressants Against Stress [PDF]
Frontiers in Pharmacology, 2022 Monoamine-based antidepressants can prophylactically protect against stress-induced gastric ulcers. Although the central nucleus of amygdala (CeA) has been shown to modulate the severity of stress ulcers, little is known about the molecular mechanisms ...
Kaiyun Yao +12 more
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An unusual case of a toddler with Canavan disease with frequent intractable seizures: A case report and review of the literature [PDF]
SAGE Open Medical Case Reports, 2023 Canavan disease is a rare fetal inherited leukodystrophy, caused by accumulation of N-acetyl-aspartate in the brain. Here, we report a child presented with frequent intractable seizures and visual impairment. A 14-month-old female infant with a complaint
Rana Irilouzadian +5 more
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Adeno-associated virus-mediated gene therapy in a patient with Canavan disease using dual routes of administration and immune modulation [PDF]
Molecular Therapy: Methods & Clinical Development, 2023 Gene replacement therapy is a rational therapeutic strategy and clinical intervention for neurodegenerative disorders like Canavan disease, a leukodystrophy caused by biallelic mutations in the aspartoacylase (ASPA) gene.
Manuela Corti +17 more
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Congenital spongiform leukodystrophy in 2 female littermate German shepherd puppies [PDF]
Journal of Veterinary Internal MedicineTwo 9‐week‐old female littermate German Shepherd puppies showed severe high‐frequency low‐amplitude trembling that worsened with movement. The white matter (WM) of the central nervous system (CNS) showed bilateral diffuse severe spongiosis in the ...
Ricardo De Miguel +5 more
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Cellular and molecular mechanisms of aspartoacylase and its role in Canavan disease [PDF]
Cell & BioscienceCanavan disease is an autosomal recessive and lethal neurological disorder, characterized by the spongy degeneration of the white matter in the brain. The disease is caused by a deficiency of the cytosolic aspartoacylase (ASPA) enzyme, which catalyzes ...
Martin Grønbæk-Thygesen +1 more
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N-acetylaspartate promotes glycolytic-to-oxidative fiber-type switch and resistance to atrophic stimuli in myotubes [PDF]
Cell Death and DiseaseN-acetylaspartate (NAA) is a neuronal metabolite that can be extruded in extracellular fluids and whose blood concentration increases in several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Serena Castelli +8 more
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