Results 41 to 50 of about 1,754 (190)

Identification and Characterization of Hypothalamic Alternative Splicing Events and Variants in Ovine Fecundity-Related Genes

Animals, 2020
Previous studies revealed that alternative splicing (AS) events and gene variants played key roles in reproduction; however, their location and distribution in hypothalamic fecundity-related genes in sheep without the FecB mutation remain largely unknown.
Zhuangbiao Zhang, Jishun Tang, Xiaoyun He, Ran Di, Xiaosheng Zhang, Jinlong Zhang, Wenping Hu, Mingxing Chu   +7 more
doaj   +1 more source

Canavan disease [PDF]

, 2005
Canavan disease (CD) is an autosomal recessive disorder, characterized by spongiform degeneration of the white matter of the brain. Aspartoacylase (ASPA) hydrolyses N-acetylaspartic acid to aspartate and acetate.
Surendran, Sankar
core  

Revisiting mouse peritoneal macrophages: heterogeneity, development, and function [PDF]

, 2015
Tissue macrophages play a crucial role in the maintenance of tissue homeostasis and also contribute to inflammatory and reparatory responses during pathogenic infection and tissue injury.
Abutbul, Ajami, Aschoff, Auffray, Auffray, Austyn, Barth, Bastos, Baumgarth, Bedoret, Butovsky, Cain, Cassado Ados, Chorro, Chorro, Cohn, Cohn, Cohn, Cohn, Daems, Dahdah, Davies, Davies, Davies, Dimri, Dioszeghy, Fogg, Gautier, Geissmann, Geissmann, Geissmann, Ghosn, Ghosn, Ghosn, Ginhoux, Ginhoux, Ginhoux, Gordon, Gordon, Gordon, Guilliams, Guilliams, Haldar, Hashimoto, Herrero, Hickstein, Hoeffel, Hume, Hume, Hume, Hume, Hume, Hume, Hume, Hume, Kantor, Kohyama, Lagasse, Landsman, Leijh, Lloberas, Machado, Makwana, Mantovani, Mantovani, Martinez, Melnicoff, Metchnikoff, Mills, Mosser, Mosser, Okabe, Parwaresch, Petty, Rosas, Rosas, Schleicher, Schulz, Shortman, Sieweke, Steinman, Takahashi, Taylor, Taylor, Taylor, Van, van Furth, van Furth, van Furth, van Furth, van Furth, van Furth, Wang, Wijffels, Wynn, Yona, Zigmond   +96 more
core   +2 more sources

CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity

Glia, Volume 74, Issue 3, March 2026.
CDC42‐effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin‐dependent scaffolding of myelin. Myelin outfoldings do not cause secondary neuropathology per se. ABSTRACT The regular structure of CNS myelin requires specialized structural proteins, including septin ...
Sophie Hümmert, Joana Paes de Faria, Olaf Jahn, Ege Bilgin, Nikola Łukasik, Chethana Rao, Mišo Mitkovski, Fritz Benseler, Nils Brose, Sophie B. Siems, Sandra Goebbels, Wiebke Möbius, Helge Ewers, João B. Relvas, Hauke B. Werner   +14 more
wiley   +1 more source

Noninvasive 11.7‐T Magnetic Resonance Spectroscopy and Imaging Reveals Retinal Metabolic Alterations Induced by Blue Light Exposure

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
Retinal metabolic changes were analyzed using proton magnetic resonance spectroscopy (1H‐MRS), marking an initial application of this non‐invasive method on living eyes. Key metabolites were identified within the retinal region of adult rats. The observed changes following intense blue light exposure were predominantly attributable to the retina, as it
Lacramioara Samoila, Alexandru Farcasanu, Simion Simon, Ede Bodoki, Ovidiu Samoila, Oliviu Vostinaru, Elena Dinte, Andreea Elena Bodoki, Dan Iudean, Calin Muresan, Simona Clichici   +10 more
wiley   +1 more source

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer [PDF]

, 2014
Metabolic remodeling is now widely regarded as a hallmark of cancer, but it is not clear whether individual metabolic strategies are frequently exploited by many tumours.
Asplund, Anna, Huang, Jenny, Jain, Mohit, Kampf, Caroline, Madhusudhan, Nikhil, Mootha, Vamsi K, Nilsson, Roland, Sheppard, Nina Gustafsson, Strittmatter, Laura   +8 more
core   +1 more source

Breast Cancer Brain Metastasis: Bridging Biological Mechanisms to Therapeutic Innovations

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Breast cancer brain metastasis (BCBrM) is driven by a multistep metastatic cascade and shaped by dynamic tumor–brain interactions. This review integrates current mechanistic insights, from molecular signaling pathways to immune evasion, and evaluates preclinical models and emerging therapies.
Jing Feng, Yuwei Tao, Fengkai Li, Suling Liu   +3 more
wiley   +1 more source

Aspartoacylase gene knockout results in severe vacuolation in the white matter and gray matter of the spinal cord in the mouse

Neurobiology of Disease, 2005
Canavan disease (CD) is a neurodegenerative disorder characterized by the spongy degeneration of the white matter of the brain. Aspartoacylase (ASPA) gene mutation resulting enzyme deficiency is the basic cause of CD.
Sankar Surendran, Gerald A. Campbell, Stephen K. Tyring, Reuben Matalon   +3 more
doaj   +1 more source

The natural history of Canavan disease: 23 new cases and comparison with patients from literature

Orphanet Journal of Rare Diseases, 2021
Background Canavan disease (CD, MIM # 271900) is a rare and devastating leukodystrophy of early childhood. To identify clinical features that could serve as endpoints for treatment trials, the clinical course of CD was studied retrospectively and ...
Annette Bley, Jonas Denecke, Alfried Kohlschütter, Gerhard Schön, Sandra Hischke, Philipp Guder, Tatjana Bierhals, Heather Lau, Maja Hempel, Florian S. Eichler   +9 more
doaj   +1 more source

AAV-Mediated Overexpression of the CB1 Receptor in the mPFC of Adult Rats Alters Cognitive Flexibility, Social Behavior, and Emotional Reactivity [PDF]

, 2011
The endocannabinoid (ECB) system is strongly involved in the regulation of cognitive processing and emotional behavior and evidence indicates that ECB signaling might affect these behavioral abilities by modulations of prefrontal cortical functions.
Matthias Klugmann, Anja Goepfrich, Chris M. Friemel, Miriam Schneider   +3 more
core   +2 more sources