Results 61 to 70 of about 1,754 (190)
Glutathione Deficit Affects the Integrity and Function of the Fimbria/Fornix and Anterior Commissure in Mice: Relevance for Schizophrenia. [PDF]
, 2015 Structural anomalies of white matter are found in various brain regions of patients with schizophrenia and bipolar and other psychiatric disorders, but the causes at the cellular and molecular levels remain unclear.
Corcoba, A. +7 more
core +2 more sources
The contribution of extracellular RNA and its derived biomaterials in disease management
BMEMat, Volume 3, Issue 2, June 2025.The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei +8 more
wiley +1 more source
New Transposon Tools Tailored for Metabolic Engineering of Gram-Negative Microbial Cell Factories [PDF]
, 2014 Re-programming microorganisms to modify their existing functions and/or to bestow bacteria with entirely new-to-Nature tasks have largely relied so far on specialized molecular biology tools.
Esteban MartÃnez-GarcÃa +3 more
core +2 more sources
Glia, Volume 73, Issue 1, Page 38-56, January 2025.Main Points We analyze myelin purified from mouse CNS tissue by quantitative proteomics. The protein composition of myelin matures between P18 and P75. Regional heterogeneity but no sex‐dependent divergence of the CNS myelin proteome. Abstract The molecules that constitute myelin are critical for the integrity of axon/myelin‐units and thus speed and ...
Sophie B. Siems +9 more
wiley +1 more source
ラットの高精度比較ゲノムマップの構築と神経系ミュータントの原因遺伝子同定研究 [PDF]
, 2004 平成12-15年度科学研究費補助金 (基盤研究(A)(1)研究成果報告書 課題番号：12308044 研究代表者：芹川忠夫(京都大学大学院医学研究科 ...
芹川, 忠夫
core
Niche signals and transcription factors involved in tissue-resident macrophage development [PDF]
, 2018 Tissue-resident macrophages form an essential part of the first line of defense in all tissues of the body. Next to their immunological role, they play an important role in maintaining tissue homeostasis. Recently, it was shown that they are primarily of
Bonnardel, Johnny +2 more
core +2 more sources
Unraveling the role of oligodendrocytes and myelin in pain
Journal of Neurochemistry, Volume 169, Issue 1, January 2025.This review includes 12 studies focusing on neuropathic pain resulting from peripheral nerve or spinal cord injuries, chemotherapy, and HIV. The studies indicate that reduced oligodendrocyte numbers and decreased myelin thickness may play a crucial role in the development or maintenance of pain. Additionally, an increase in OPCs could aid in repair, as
Woojin Kim, María Cecilia Angulo
wiley +1 more source
N-Acetylaspartate Metabolism Outside the Brain: Lipogenesis, Histone Acetylation, and Cancer
Frontiers in Endocrinology, 2017 N-acetylaspartate (NAA) is a highly abundant brain metabolite. Aberrant NAA concentrations have been detected in many pathological conditions and although the function of NAA has been extensively investigated in the brain it is still controversial.
Juliane G. Bogner-Strauss +1 more
doaj +1 more source
Impacts of hnRNP A1 Splicing Inhibition on the Brain Remyelination Proteome
Journal of Neurochemistry, Volume 169, Issue 1, January 2025.This study highlights the effects of hnRNP A1 on myelin proteins in the prefrontal cortex, corpus callosum, and hippocampus of adult mice following cuprizone‐induced demyelination and subsequent hnRNP A1 splicing inhibition (VPC‐8001) during remyelination. VPC‐8001 exposure induced significant changes in myelination proteins such as MOG, MAG, MBP, CNP,
Caroline Brandão‐Teles +10 more
wiley +1 more source
Structural modeling of p.V31F variant in the aspartoacylase gene
Metabolic Brain Disease, 2016 Aspartoacylase (ASPA) is an abundant enzyme in the brain, which catalyzes the conversion of N-acetylaspartate into acetate and aspartate, deficiency in its activity leads to degeneration of the white matter of the brain and is a recognized cause of Canavan disease (CD), which affect children.
Krishnamoorthy, Navaneethakrishnan +1 more
openaire +4 more sources