Results 61 to 70 of about 1,111 (177)

The contribution of extracellular RNA and its derived biomaterials in disease management

BMEMat, Volume 3, Issue 2, June 2025.
The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei, Zhangyi Wang, Zixuan Qin, Qianqian Wan, Yutao Li, Franklin R. Tay, Chenyu Wang, Tong Zhang, Lina Niu   +8 more
wiley   +1 more source

Developmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome

Glia, Volume 73, Issue 1, Page 38-56, January 2025.
Main Points We analyze myelin purified from mouse CNS tissue by quantitative proteomics. The protein composition of myelin matures between P18 and P75. Regional heterogeneity but no sex‐dependent divergence of the CNS myelin proteome. Abstract The molecules that constitute myelin are critical for the integrity of axon/myelin‐units and thus speed and ...
Sophie B. Siems, Vasiliki‐Ilya Gargareta, Leonie C. Schadt, Vinicius Daguano Gastaldi, Ramona B. Jung, Lars Piepkorn, Patrizia Casaccia, Ting Sun, Olaf Jahn, Hauke B. Werner   +9 more
wiley   +1 more source

Unraveling the role of oligodendrocytes and myelin in pain

Journal of Neurochemistry, Volume 169, Issue 1, January 2025.
This review includes 12 studies focusing on neuropathic pain resulting from peripheral nerve or spinal cord injuries, chemotherapy, and HIV. The studies indicate that reduced oligodendrocyte numbers and decreased myelin thickness may play a crucial role in the development or maintenance of pain. Additionally, an increase in OPCs could aid in repair, as
Woojin Kim, María Cecilia Angulo
wiley   +1 more source

Fibroblastic aspartoacylase suppresses TGFβ-mediated responses and cancer progression

Nature Communications
Metabolic reprogramming is a hallmark of cancer, and the field has predominantly focused on investigating metabolic alterations in tumour cells.
Ianire Astobiza, Catalina Capó-Serra, Cristina Viera, Javier Rodríguez, Patricia Carnicero, Miguel Juliá, Ainara Martinez, Carmen Pérez-López, María Subijana, Carolina Ortiz-Sanz, Saioa Garcia-Longarte, Isabel Mendizabal, Emily J. Kay, Carla Riera-Domingo, Silvia Rivis, Onintza Carlevaris, Leire Egia-Mendikute, Sara Cascais, Natalia Martín-Martín, Sonia Fernandez-Ruiz, Veronica Torrano, Jana R. Crespo, Mikel Pujana-Vaquerizo, Elisa Espinet, Andreas Trumpp, Noemi Eiro, Francisco J. Vizoso, Ana Vivancos, Joan Seoane, David Gonzalo, Sofia Rey, Aida Santos-Martin, Aitziber Ugalde-Olano, Claudia Manini, Jose I. Lopez, Diana Cabrera, Sebastian M. Van Liempd, Juan M. Falcon-Perez, Roger R. Gomis, Asís Palazon, Christian Frezza, Mireia Castillo-Martin, Sara Zanivan, Massimiliano Mazzone, Miguel Unda, Ana Loizaga-Iriarte, Arkaitz Carracedo, Fernando Calvo   +47 more
doaj   +1 more source

Impacts of hnRNP A1 Splicing Inhibition on the Brain Remyelination Proteome

Journal of Neurochemistry, Volume 169, Issue 1, January 2025.
This study highlights the effects of hnRNP A1 on myelin proteins in the prefrontal cortex, corpus callosum, and hippocampus of adult mice following cuprizone‐induced demyelination and subsequent hnRNP A1 splicing inhibition (VPC‐8001) during remyelination. VPC‐8001 exposure induced significant changes in myelination proteins such as MOG, MAG, MBP, CNP,
Caroline Brandão‐Teles, Victor Corasolla Carregari, Guilherme Reis‐de‐Oliveira, Bradley J. Smith, Yane Chaves, Aline Valéria Sousa Santos, Erick Martins de Carvalho Pinheiro, Caio C. Oliveira, Andre Schwambach Vieira, Fernanda Crunfli, Daniel Martins‐de‐Souza   +10 more
wiley   +1 more source

N-Acetylaspartate Metabolism Outside the Brain: Lipogenesis, Histone Acetylation, and Cancer

Frontiers in Endocrinology, 2017
N-acetylaspartate (NAA) is a highly abundant brain metabolite. Aberrant NAA concentrations have been detected in many pathological conditions and although the function of NAA has been extensively investigated in the brain it is still controversial.
Juliane G. Bogner-Strauss, Juliane G. Bogner-Strauss   +1 more
doaj   +1 more source

Systemic Treatment of Body‐Wide Duchenne Muscular Dystrophy Symptoms

Clinical Pharmacology &Therapeutics, Volume 116, Issue 6, Page 1472-1484, December 2024.
Duchenne muscular dystrophy (DMD) is a fatal X‐linked disease that leads to premature death due to the loss of dystrophin. Current strategies predominantly focus on the therapeutic treatment of affected skeletal muscle tissue. However, certain results point to the fact that with successful treatment of skeletal muscle, DMD‐exposed latent phenotypes in ...
Patryk Konieczny
wiley   +1 more source

Novel Mutation of Aspartoacylase Gene in a Turkish Patient with Canavan Disease [PDF]

Journal of Tropical Pediatrics, 2007
Canavan disease is a neurodegenerative disease with autosomal recessive inheritance. Although this disease is prevalant among Ashkenazi Jewish population, several cases have been reported from all over the world. Canavan disease is caused by a genetic mutation in aspartoacylase gene. We have identified a novel mutation, a homozygous C432+1G>A mutation,
Aycan, Unalp, Ender, Altiok, Nedret, Uran, Aysel, Oztürk, Sirin, Yüksel   +4 more
openaire   +2 more sources

Multiomics analysis reveals the potential mechanism of high‐fat diet in dextran sulfate sodium‐induced colitis mice model

Food Science &Nutrition, Volume 12, Issue 10, Page 8309-8323, October 2024.
HFD‐treated mice exhibited notable alternations in the structure and composition of the gut microbiota, with some of these alternations being associated with the pathogenesis of IBD. Analysis of the colon transcriptome revealed 11 hub genes and 7 hub pathways among control, DSS‐induced colitis, and HFD + DSS‐treated groups. Impact of HFD on DSS‐induced
Yuyang Zhao, Zhimin Chen, Ruiyi Dong, Yufan Liu, Yixin Zhang, Yan Guo, Meiyi Yu, Xiang Li, Jiangbin Wang   +8 more
wiley   +1 more source

Mutation detection in the aspartoacylase gene in 17 patients with Canavan disease: four new mutations in the non-Jewish population

, 2000
Canavan disease is a severe progressive autosomal recessive disorder, which is characterised by spongy degeneration of the brain. The disease is caused by mutations in the aspartoacylase gene.
Coo, I.F.M. de, Kleijer, W.J., Sistermans, E. A., De Coo, René F.M., Beerendonk, H.M. van, Tien Poll-The, B, van Beerendonk, H. M., van Oost, B. A., van Beerendonk, HM, Sistermans, Erik A., Sistermans, EA, Poll-The, Bwee Tien, Van Oost, Bernard A., Coo, IFM, Poll-The, B.T., Sistermans, E.A., Van Beerendonk, Hetty M., Kleijer, W. J., Kleijer, Wim J., van Oost, BA, de Coo, R. F., Kleijer, W, Oost, B.A. van, Poll-The, B. T.   +23 more
core   +1 more source