Results 71 to 80 of about 1,754 (190)
Developmental and regional distribution of aspartoacylase in rat brain tissue [PDF]
Journal of Neurochemistry, 2001 The function of N‐acetyl‐aspartate (NAA), a predominant molecule in the brain, has not yet been determined. However, NAA is commonly used as a putative marker of viable neurones. To investigate the possible function of NAA, we determined the anatomical, developmental and cellular distribution of aspartoacylase, which catalyses the hydrolysis of NAA ...
K K, Bhakoo, T J, Craig, P, Styles
openaire +2 more sources
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis [PDF]
, 2017 Evaluation of transcriptional changes in the striatum may be an effective approach to understanding the natural history of changes in expression contributing to the pathogenesis of Huntington disease (HD).
Becanovic, Kristina +7 more
core
Rotavirus infection causing gastroenteritis is one of the major health concerns throughout the world. Millions of children are affected by the disease.
Surendran, Sankar
core +1 more source
Stress-response pathways are altered in the hippocampus of chronic alcoholics [PDF]
, 2013 The chronic high-level alcohol consumption seen in alcoholism leads to dramatic effects on the hippocampus, including decreased white matter, loss of oligodendrocytes and other glial cells, and inhibition of neurogenesis.
Edenberg, Howard J. +7 more
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Systemic Treatment of Body‐Wide Duchenne Muscular Dystrophy Symptoms
Clinical Pharmacology &Therapeutics, Volume 116, Issue 6, Page 1472-1484, December 2024.Duchenne muscular dystrophy (DMD) is a fatal X‐linked disease that leads to premature death due to the loss of dystrophin. Current strategies predominantly focus on the therapeutic treatment of affected skeletal muscle tissue. However, certain results point to the fact that with successful treatment of skeletal muscle, DMD‐exposed latent phenotypes in ...
Patryk Konieczny
wiley +1 more source
Bimodal occurrence of aspartoacylase in myelin and cytosol of brain [PDF]
Journal of Neurochemistry, 2006 AbstractThe growing use of N‐acetylaspartate as an indicator of neuronal viability has fostered interest in the biological function(s) of this unusual amino acid derivative. In considering the various physiological roles that have been proposed for this relatively abundant molecule one is obliged to take into account its unusual metabolic ...
Jianfeng, Wang +7 more
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Loss of central auditory processing in a mouse model of Canavan disease.
PLoS ONE, 2014 Canavan Disease (CD) is a leukodystrophy caused by homozygous null mutations in the gene encoding aspartoacylase (ASPA). ASPA-deficiency is characterized by severe psychomotor retardation, and excessive levels of the ASPA substrate N-acetylaspartate (NAA)
Georg von Jonquieres +5 more
doaj +1 more source
Food Science &Nutrition, Volume 12, Issue 10, Page 8309-8323, October 2024.HFD‐treated mice exhibited notable alternations in the structure and composition of the gut microbiota, with some of these alternations being associated with the pathogenesis of IBD. Analysis of the colon transcriptome revealed 11 hub genes and 7 hub pathways among control, DSS‐induced colitis, and HFD + DSS‐treated groups. Impact of HFD on DSS‐induced
Yuyang Zhao +8 more
wiley +1 more source
Glial promoter selectivity following AAV-delivery to the immature brain.
PLoS ONE, 2013 Recombinant adeno-associated virus (AAV) vectors are versatile tools for gene transfer to the central nervous system (CNS) and proof-of-concept studies in adult rodents have shown that the use of cell type-specific promoters is sufficient to target AAV ...
Georg von Jonquieres +9 more
doaj +1 more source
Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts [PDF]
, 2016 BIN1 is not expressed in human brain microglial cells. (A) Immunohistochemical staining of adjacent sections of normal human brain cortex with antibodies against BIN1 or Iba1 reveals that BIN1 immunoreactive cells that are morphologically distinct from ...
Alexandra Botté +17 more
core +8 more sources